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    Dbndd2 dysbindin domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 52840, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dbndd2provided by MGI
    Official Full Name
    dysbindin domain containing 2provided by MGI
    Primary source
    MGI:MGI:106562
    See related
    Ensembl:ENSMUSG00000017734 AllianceGenome:MGI:106562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nkip; R74724; D2Bwg0891e; 1110017A21Rik; 2900022J10Rik
    Summary
    Enables ATPase binding activity. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; monoatomic ion homeostasis; and neuron projection development. Is active in endoplasmic reticulum and lysosome. Is expressed in genital tubercle and urethral plate. Orthologous to human DBNDD2 (dysbindin domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 38.8), cortex adult (RPKM 22.6) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dbndd2 in Genome Data Viewer
    Location:
    2 H3; 2 85.17 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164309073..164335243)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164467153..164493323)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene matrilin 4 Neighboring gene STARR-positive B cell enhancer ABC_E6015 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region-like Neighboring gene STARR-positive B cell enhancer ABC_E4517 Neighboring gene STARR-positive B cell enhancer ABC_E6016 Neighboring gene STARR-seq mESC enhancer starr_06326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164266728-164266915 Neighboring gene syndecan 4 Neighboring gene STARR-seq mESC enhancer starr_06330 Neighboring gene STARR-positive B cell enhancer ABC_E7884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164286295-164286478 Neighboring gene SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) Neighboring gene transformation related protein 53 target 5 Neighboring gene STARR-positive B cell enhancer ABC_E9539 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class T Neighboring gene STARR-seq mESC enhancer starr_06331 Neighboring gene predicted gene, 36090

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of NKIP: a novel, Na+/K+-ATPase interacting protein mediates neural differentiation and apoptosis. Pratscher B, et al. Exp Cell Res, 2008 Feb 1. PMID 18096156
    2. The schizophrenia susceptibility gene dysbindin regulates dendritic spine dynamics. Jia JM, et al. J Neurosci, 2014 Oct 8. PMID 25297099, Free PMC Article
    3. Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium. Armfield BA, et al. J Urol, 2016 Oct. PMID 27173853, Free PMC Article
    4. Somatic cell hybrids for high-density mapping of chromosome 2 breakpoints in radiation-induced myeloid leukemia cell lines from inbred mice. Pazzaglia S, et al. Mol Carcinog, 2000 Mar. PMID 10708484
    5. PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression. Kirchhof P, et al. Circ Cardiovasc Genet, 2011 Apr. PMID 21282332

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neurogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dysbindin domain-containing protein 2
    Names
    SCF apoptosis response protein 1
    dysbindin (dystrobrevin binding protein 1) domain containing 2
    likely orthologue of H. sapiens chromosome 20 open reading frame 35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048227.1 → NP_001041692.1  dysbindin domain-containing protein 2

      See identical proteins and their annotated locations for NP_001041692.1

      Status: VALIDATED

      Source sequence(s)
      AL591478, BG080686, CX241653
      Consensus CDS
      CCDS38322.1
      UniProtKB/Swiss-Prot
      Q9CRD4
      UniProtKB/TrEMBL
      Q330P7
      Related
      ENSMUSP00000104974.3, ENSMUST00000109350.9
      Conserved Domains (1) summary
      pfam04440
      Location:12 → 80
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

    2. NM_001048228.1 → NP_001041693.1  dysbindin domain-containing protein 2

      See identical proteins and their annotated locations for NP_001041693.1

      Status: VALIDATED

      Source sequence(s)
      AK003735, AL591478
      Consensus CDS
      CCDS38322.1
      UniProtKB/Swiss-Prot
      Q9CRD4
      UniProtKB/TrEMBL
      Q330P7
      Related
      ENSMUSP00000104973.3, ENSMUST00000109349.9
      Conserved Domains (1) summary
      pfam04440
      Location:12 → 80
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

    3. NM_001048229.1 → NP_001041694.1  dysbindin domain-containing protein 2

      See identical proteins and their annotated locations for NP_001041694.1

      Status: VALIDATED

      Source sequence(s)
      AL591478, CJ156083, CX241653
      Consensus CDS
      CCDS38322.1
      UniProtKB/Swiss-Prot
      Q9CRD4
      UniProtKB/TrEMBL
      Q330P7
      Related
      ENSMUSP00000017878.3, ENSMUST00000017878.3
      Conserved Domains (1) summary
      pfam04440
      Location:12 → 80
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

    4. NM_026797.2 → NP_081073.1  dysbindin domain-containing protein 2

      See identical proteins and their annotated locations for NP_081073.1

      Status: VALIDATED

      Source sequence(s)
      AL591478, CX241653
      Consensus CDS
      CCDS38322.1
      UniProtKB/Swiss-Prot
      Q9CRD4
      UniProtKB/TrEMBL
      Q330P7
      Related
      ENSMUSP00000064437.9, ENSMUST00000069385.15
      Conserved Domains (1) summary
      pfam04440
      Location:12 → 80
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164309073..164335243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499895.3 → XP_006499958.1  dysbindin domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006499958.1

      UniProtKB/Swiss-Prot
      Q9CRD4
      UniProtKB/TrEMBL
      Q330P7
      Conserved Domains (1) summary
      pfam04440
      Location:12 → 80
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

    2. XM_030251864.2 → XP_030107724.1  dysbindin domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9CRD4
      UniProtKB/TrEMBL
      Q330P7
      Conserved Domains (1) summary
      pfam04440
      Location:12 → 80
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRD4.1 GenPept UniProtKB/Swiss-Prot:Q9CRD4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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