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    RNR2A ribonucleotide reductase 2A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821937, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RNR2A
    Official Full Name
    ribonucleotide reductase 2A
    Primary source
    TAIR:AT3G23580
    Locus tag
    AT3G23580
    See related
    Araport:AT3G23580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ribonucleotide reductase 2A; RNR2
    Summary
    Encodes one of the 3 ribonucleotide reductase (RNR) small subunit genes (RNR2A). Functionally redundant with the ribonucleotide reductase TSO2. mRNA was shown to specifically accumulate during the S-phase of the cell cycle in synchronized tobacco BY2 cells. Critical for cell cycle progression, DNA damage repair and plant development.
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    Genomic context

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    See RNR2A in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (8459838..8462815)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene MATE efflux family protein Neighboring gene MATE efflux family protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An active ribonucleotide reductase from Arabidopsis thaliana cloning, expression and characterization of the large subunit. Sauge-Merle S, et al. Eur J Biochem, 1999 Nov. PMID 10542051
    2. Molecular characterization and cell cycle-regulated expression of a cDNA clone from Arabidopsis thaliana homologous to the small subunit of ribonucleotide reductase. Philipps G, et al. FEBS Lett, 1995 Jan 16. PMID 7821432
    3. Arabidopsis ribonucleotide reductases are critical for cell cycle progression, DNA damage repair, and plant development. Wang C, et al. Plant Cell, 2006 Feb. PMID 16399800, Free PMC Article
    4. Ribonucleotide reductase regulation in response to genotoxic stress in Arabidopsis. Roa H, et al. Plant Physiol, 2009 Sep. PMID 19571309, Free PMC Article
    5. COP9 signalosome subunit 7 from Arabidopsis interacts with and regulates the small subunit of ribonucleotide reductase (RNR2). Halimi Y, et al. Plant Mol Biol, 2011 Sep. PMID 21614643

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_113261.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ribonucleotide metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    part_of ribonucleoside-diphosphate reductase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribonucleotide reductase 2A
    NP_189000.1
    • ribonucleotide reductase 2A (RNR2A); CONTAINS InterPro DOMAIN/s: Ribonucleotide reductase-related (InterPro:IPR012348), Ribonucleotide reductase (InterPro:IPR000358), Ferritin/ribonucleotide reductase-like (InterPro:IPR009078); BEST Arabidopsis thaliana protein match is: Ferritin/ribonucleotide reductase-like family protein (TAIR:AT3G27060.1); Has 9602 Blast hits to 9597 proteins in 2376 species: Archae - 34; Bacteria - 4358; Metazoa - 261; Fungi - 240; Plants - 185; Viruses - 729; Other Eukaryotes - 3795 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8459838..8462815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113261.4 → NP_189000.1  ribonucleotide reductase 2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189000.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P50651, Q9LUH0
      UniProtKB/TrEMBL
      A0A178V929
      Conserved Domains (1) summary
      PLN02492
      Location:19 → 341
      PLN02492; ribonucleoside-diphosphate reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50651.2

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