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    DWF1 cell elongation protein / DWARF1 / DIMINUTO (DIM) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821519, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DWF1
    Official Full Name
    cell elongation protein / DWARF1 / DIMINUTO (DIM)
    Primary source
    TAIR:AT3G19820
    Locus tag
    AT3G19820
    See related
    Araport:AT3G19820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CABBAGE 1; CBB1; DIM; DIM1; DIMINUTIA; DIMINUTO 1; DWARF 1; ENHANCED VERY-LOW-FLUENCE RESPONSES 1; EVE1
    Summary
    Involved in the conversion of the early brassinosteroid precursor 24-methylenecholesterol to campesterol. Brassinosteroids affect cellular elongation. Mutants have dwarf phenotype. DWF1 is a Ca2+-dependent calmodulin-binding protein.
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    Genomic context

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    See DWF1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (6879524..6882315, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene E3 ubiquitin-protein ligase, putative (DUF177) Neighboring gene BTB/POZ domain protein, putative (DUF177) Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene ncRNA Neighboring gene pre-mRNA-processing protein 40C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DIMINUTO gene of Arabidopsis is involved in regulating cell elongation. Takahashi T, et al. Genes Dev, 1995 Jan 1. PMID 7828854
    2. The Arabidopsis DIMINUTO/DWARF1 gene encodes a protein involved in steroid synthesis. Klahre U, et al. Plant Cell, 1998 Oct. PMID 9761794, Free PMC Article
    3. Function and molecular regulation of DWARF1 as a C-24 reductase in brassinosteroid biosynthesis in Arabidopsis. Youn JH, et al. J Exp Bot, 2018 Apr 9. PMID 29432595, Free PMC Article
    4. The Arabidopsis dwarf1 mutant is defective in the conversion of 24-methylenecholesterol to campesterol in brassinosteroid biosynthesis. Choe S, et al. Plant Physiol, 1999 Mar. PMID 10069828, Free PMC Article
    5. The Rice brassinosteroid-deficient dwarf2 mutant, defective in the rice homolog of Arabidopsis DIMINUTO/DWARF1, is rescued by the endogenously accumulated alternative bioactive brassinosteroid, dolichosterone. Hong Z, et al. Plant Cell, 2005 Aug. PMID 15994910, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biosynthesis of 24-methylene brassinolide is an alternative route for generating CS, which is mediated and regulated by DWF1 in Arabidopsis.
      Title: Function and molecular regulation of DWARF1 as a C-24 reductase in brassinosteroid biosynthesis in Arabidopsis.
    2. both Delta(5,7)-sterol-Delta(7)-reductase and Delta(24)-sterol-Delta(24)-reductase are in addition localized to the plasma membrane, whereas Delta(7)-sterol-C(5)-desaturase was clearly detected in lipid particles
      Title: Plant sterol metabolism. Δ(7)-Sterol-C5-desaturase (STE1/DWARF7), Δ(5,7)-sterol-Δ(7)-reductase (DWARF5) and Δ(24)-sterol-Δ(24)-reductase (DIMINUTO/DWARF1) show multiple subcellular localizations in Arabidopsis thaliana (Heynh) L.
    3. Data indicate a role for DIM1 in secondary cell wall formation.
      Title: DIMINUTO 1 affects the lignin profile and secondary cell wall formation in Arabidopsis.
    4. The genomic location of the EVE1 gene in Arabidopsis thaliana corresponded to a bacterial artificial chromosome (BAC) F4C21 from chromosome IV at ~17cM which encoded a novel ubiquitin family protein (At4g03350), consisting of a single exon.
      Title: Overexpression of EVE1, a novel ubiquitin family protein, arrests inflorescence stem development in Arabidopsis.
    5. results provide direct proof that Ca2+/calmodulin-mediated signalling has a critical role in controlling the function of DWF1 [DWARF1]
      Title: Ca2+/calmodulin is critical for brassinosteroid biosynthesis and plant growth.
    6. Overproduction and repression of Dim/dwf1 resulted in contrasting phenotypes, with repressors mimicking the brd2 phenotype and overproducers having large stature with increased numbers of flowers and seeds.
      Title: The Rice brassinosteroid-deficient dwarf2 mutant, defective in the rice homolog of Arabidopsis DIMINUTO/DWARF1, is rescued by the endogenously accumulated alternative bioactive brassinosteroid, dolichosterone.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001338420.1
    NM_112872.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables delta24-sterol reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within brassinosteroid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within brassinosteroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lignin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type secondary cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within steroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    cell elongation protein / DWARF1 / DIMINUTO (DIM)
    NP_001319595.1
    • DWARF 1 (DWF1); CONTAINS InterPro DOMAIN/s: FAD-linked oxidase, FAD-binding, subdomain 2 (InterPro:IPR016168), FAD-binding, type 2 (InterPro:IPR016166), FAD linked oxidase, N-terminal (InterPro:IPR006094).
    NP_188616.1
    • DWARF 1 (DWF1); FUNCTIONS IN: calmodulin binding, catalytic activity; INVOLVED IN: response to light stimulus, steroid biosynthetic process, unidimensional cell growth, brassinosteroid biosynthetic process; LOCATED IN: integral to membrane, plasma membrane, vacuole, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: FAD-linked oxidase, FAD-binding, subdomain 2 (InterPro:IPR016168), FAD-binding, type 2 (InterPro:IPR016166), FAD linked oxidase, N-terminal (InterPro:IPR006094); Has 2747 Blast hits to 2744 proteins in 657 species: Archae - 35; Bacteria - 1665; Metazoa - 178; Fungi - 472; Plants - 176; Viruses - 0; Other Eukaryotes - 221 (source: NCBI BLink).
    NP_850616.1
    • DWARF 1 (DWF1); FUNCTIONS IN: calmodulin binding, catalytic activity; INVOLVED IN: response to light stimulus, steroid biosynthetic process, unidimensional cell growth, brassinosteroid biosynthetic process; LOCATED IN: integral to membrane, plasma membrane, vacuole, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: FAD-linked oxidase, FAD-binding, subdomain 2 (InterPro:IPR016168), FAD-binding, type 2 (InterPro:IPR016166), FAD linked oxidase, N-terminal (InterPro:IPR006094); Has 2747 Blast hits to 2744 proteins in 657 species: Archae - 35; Bacteria - 1665; Metazoa - 178; Fungi - 472; Plants - 176; Viruses - 0; Other Eukaryotes - 221 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6879524..6882315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180285.4 → NP_850616.1  cell elongation protein / DWARF1 / DIMINUTO (DIM) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850616.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WWL4, Q38808, Q39085, Q8RXF4
      UniProtKB/TrEMBL
      A0A178V7D0, A0A5S9XDW3
      Conserved Domains (2) summary
      TIGR01678
      Location:108 → 407
      FAD_lactone_ox; sugar 1,4-lactone oxidases
      pfam01565
      Location:110 → 200
      FAD_binding_4; FAD binding domain

    2. NM_001338420.1 → NP_001319595.1  cell elongation protein / DWARF1 / DIMINUTO (DIM) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WWL4, Q38808, Q39085, Q8RXF4
      UniProtKB/TrEMBL
      A0A178V7D0, A0A5S9XDW3
      Conserved Domains (2) summary
      TIGR01678
      Location:108 → 407
      FAD_lactone_ox; sugar 1,4-lactone oxidases
      pfam01565
      Location:110 → 200
      FAD_binding_4; FAD binding domain

    3. NM_112872.3 → NP_188616.1  cell elongation protein / DWARF1 / DIMINUTO (DIM) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188616.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WWL4, Q38808, Q39085, Q8RXF4
      UniProtKB/TrEMBL
      A0A178V7D0, A0A5S9XDW3
      Conserved Domains (2) summary
      TIGR01678
      Location:108 → 407
      FAD_lactone_ox; sugar 1,4-lactone oxidases
      pfam01565
      Location:110 → 200
      FAD_binding_4; FAD binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39085.2

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