Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sos2provided by MGI
Official Full Name: SOS Ras/Rho guanine nucleotide exchange factor 2provided by MGI
Primary source: MGI:MGI:98355
See related: Ensembl:ENSMUSG00000034801 AllianceGenome:MGI:98355
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SOS-2; mSOS-2
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in insulin receptor signaling pathway. Acts upstream of or within several processes, including B cell homeostasis; regulation of T cell activation; and regulation of pro-B cell differentiation. Predicted to be active in plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in Noonan syndrome 9. Orthologous to human SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 5.8), CNS E18 (RPKM 5.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C2; 12 28.93 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (69630535..69728626, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (69583761..69681852, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology.
Title: SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology.
Results indicat son of sevenless homolog 2 protein (SOS2) critically mediated mutant KRAS-driven, but not HRAS-driven, transformation.
Title: Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation.
Our data unveil novel, distinctive mechanistic roles of Sos 1 and Sos2 in physiological control of skin homeostasis and wound repair, as well as in pathological development of chemically induced skin tumors.
Title: Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis.
The increased activity of the PI3K/AKT pathway led to downregulation of the surface receptor CD62L in Sos-1/2dKO T cells and a subsequent impairment in T-cell migration.
Title: Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.
Absolute counts of mature B and T cells in spleen and peripheral blood were unchanged in single-knockout mutants, while significantly reduced in Sos1/2 double-knockout mice.
Title: Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival.
assessed the independent and combined roles for the RasGEFs Sos1, Sos2, and RasGRP1 during thymocyte development
Title: Deconstructing Ras signaling in the thymus.
Sos2 is dispensable for both NMDA-induced Erk activation in cortical neuron cultures from neonatal mice, and for LTP induction at the Schaffer-CA1 synapses in brain slices from young mice that is known to require NMDA receptor signaling.
Title: Sos2 is dispensable for NMDA-induced Erk activation and LTP induction.
Vav1 transduces TCR signals to Ras by controlling recruitment of RasGRP1 to the membrane and recruitment of Sos1 and -2 to the transmembrane adapter protein LAT.
Title: Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lymphocyte homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of T cell differentiation in thymus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of T cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of pro-B cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within small GTPase-mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: son of sevenless homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135559.1 → NP_001129031.1 son of sevenless homolog 2

Status: VALIDATED

Source sequence(s)

AC133949, AC141560, AC153658

Consensus CDS

CCDS59573.1

UniProtKB/TrEMBL

A0A0A0MQ87, S4R2C4

Related

ENSMUSP00000044866.8, ENSMUST00000035773.14

Conserved Domains (7) summary

smart00147
Location:774 → 1018

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:595 → 739

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00160
Location:200 → 386

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01261
Location:437 → 543

PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain

pfam00125
Location:63 → 169

Histone; Core histone H2A/H2B/H3/H4

pfam00169
Location:443 → 544

PH; PH domain

cl23907
Location:97 → 147

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

69630535..69728626 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515635.2 → XP_006515698.1 son of sevenless homolog 2 isoform X1

See identical proteins and their annotated locations for XP_006515698.1

UniProtKB/Swiss-Prot

Q02384

UniProtKB/TrEMBL

S4R2C4

Related

ENSMUSP00000138793.2, ENSMUST00000183277.8

Conserved Domains (5) summary

smart00147
Location:775 → 1019

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:596 → 740

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00160
Location:200 → 387

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01261
Location:438 → 544

PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain

pfam00125
Location:70 → 169

Histone; Core histone H2A/H2B/H3/H4