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    Fgf22 fibroblast growth factor 22 [ Mus musculus (house mouse) ]

    Gene ID: 67112, updated on 3-Dec-2024

    Summary

    Official Symbol
    Fgf22provided by MGI
    Official Full Name
    fibroblast growth factor 22provided by MGI
    Primary source
    MGI:MGI:1914362
    See related
    Ensembl:ENSMUSG00000020327 AllianceGenome:MGI:1914362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fgf5d; FGF-22; 2210414E06Rik
    Summary
    Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in regulation of synapse maturation and trans-synaptic signaling. Located in Golgi apparatus; cell surface; and nucleolus. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Is extrinsic component of postsynaptic density membrane. Is expressed in brain; early conceptus; gonad; spinal cord; and tongue. Orthologous to human FGF22 (fibroblast growth factor 22). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 1.6), cortex adult (RPKM 1.1) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Fgf22 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79590887..79593629)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79755051..79757795)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 2 Neighboring gene polymerase (RNA) mitochondrial (DNA directed) Neighboring gene STARR-positive B cell enhancer ABC_E3897 Neighboring gene ring finger protein 126 Neighboring gene STARR-positive B cell enhancer ABC_E899 Neighboring gene STARR-positive B cell enhancer ABC_E719 Neighboring gene follistatin-like 3 Neighboring gene serine protease 57

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of synapse maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in trans-synaptic signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in trans-synaptic signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extrinsic component of postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extrinsic component of postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    fibroblast growth factor 22
    Names
    fibroblast growth factor 5d

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368662.2NP_001355591.1  fibroblast growth factor 22 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151828
      Consensus CDS
      CCDS88050.1
      UniProtKB/TrEMBL
      Q0VER9
      Related
      ENSMUSP00000151917.2, ENSMUST00000219981.2
      Conserved Domains (1) summary
      cl00060
      Location:3497
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
    2. NM_001429407.1NP_001416336.1  fibroblast growth factor 22 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AC151828
      UniProtKB/TrEMBL
      A0A1X7SB63
    3. NM_023304.3NP_075793.1  fibroblast growth factor 22 isoform 1 precursor

      See identical proteins and their annotated locations for NP_075793.1

      Status: VALIDATED

      Source sequence(s)
      AC151828
      Consensus CDS
      CCDS23988.1
      UniProtKB/Swiss-Prot
      Q9ESS2
      UniProtKB/TrEMBL
      A0A7U3JW52
      Related
      ENSMUSP00000151743.2, ENSMUST00000219228.2
      Conserved Domains (1) summary
      pfam00167
      Location:32156
      FGF; Fibroblast growth factor

    RNA

    1. NR_190732.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC151828
    2. NR_190733.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC151828

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79590887..79593629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245228.2XP_030101088.1  fibroblast growth factor 22 isoform X1

      Related
      ENSMUSP00000020577.4, ENSMUST00000020577.4
      Conserved Domains (1) summary
      cl00060
      Location:3497
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...