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    Tufm Tu translation elongation factor, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 233870, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tufmprovided by MGI
    Official Full Name
    Tu translation elongation factor, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1923686
    See related
    Ensembl:ENSMUSG00000073838 AllianceGenome:MGI:1923686
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EFTU; EF-TuMT; 2300002G02Rik
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Located in mitochondrial inner membrane and myelin sheath. Is expressed in embryo. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 4. Orthologous to human TUFM (Tu translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 104.1), heart adult (RPKM 88.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tufm in Genome Data Viewer
    Location:
    7 F3; 7 69.08 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126086445..126089903)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126487271..126490731)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133618829-133619012 Neighboring gene SH2B adaptor protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E4975 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133630590-133630777 Neighboring gene predicted gene, 46001 Neighboring gene ataxin 2-like Neighboring gene RIKEN cDNA 4930456A14 gene Neighboring gene STARR-positive B cell enhancer ABC_E555 Neighboring gene STARR-positive B cell enhancer ABC_E10474 Neighboring gene STARR-positive B cell enhancer ABC_E8209 Neighboring gene STARR-seq mESC enhancer starr_20151 Neighboring gene eukaryotic translation initiation factor 3, subunit C Neighboring gene predicted gene, 24596

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activation of mitochondrial TUFM ameliorates metabolic dysregulation through coordinating autophagy induction. Kim D, et al. Commun Biol, 2021 Jan 4. PMID 33398033, Free PMC Article
    2. FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM. Bi Y, et al. Cell Death Dis, 2022 Dec 5. PMID 36470869, Free PMC Article
    3. TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS. Zhong BR, et al. FASEB J, 2021 May. PMID 33774866
    4. Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation. Chatla S, et al. Stem Cell Res, 2019 Oct. PMID 31472450, Free PMC Article
    5. The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Lei Y, et al. Immunity, 2012 Jun 29. PMID 22749352, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM.
      Title: FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM.
    2. TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS.
      Title: TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS.
    3. Activation of mitochondrial TUFM ameliorates metabolic dysregulation through coordinating autophagy induction.
      Title: Activation of mitochondrial TUFM ameliorates metabolic dysregulation through coordinating autophagy induction.
    4. Fancd2 localizes in the mitochondrion and associates with the nucleoid complex components Atad3 and Tufm.
      Title: Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
    5. By recruiting Atg5-Atg12 and NLRX1, TUFM serves as a nodal checkpoint of the RIG-I-MAVS axis. It acts similarly to NLRX1 by inhibiting RigI-like-receptor-induced IFN-I but promoting autophagy.
      Title: The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in myelin sheath HDA PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    elongation factor Tu, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163713.1 → NP_001157185.1  elongation factor Tu, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001157185.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate segment that results in a frameshift compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK152858, BC060959, BU699735, BY246546
      Consensus CDS
      CCDS52398.1
      UniProtKB/Swiss-Prot
      Q8BFR5
      Related
      ENSMUSP00000102000.4, ENSMUST00000106392.10
      Conserved Domains (3) summary
      cd01884
      Location:56 → 250
      EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins
      pfam00009
      Location:55 → 248
      GTP_EFTU; Elongation factor Tu GTP binding domain
      cd03697
      Location:258 → 344
      EFTU_II; Domain II of elongation factor Tu

    2. NM_172745.3 → NP_766333.1  elongation factor Tu, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_766333.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK152858, BC060959, BY246546
      Consensus CDS
      CCDS21830.1
      UniProtKB/Swiss-Prot
      Q497E7, Q6P919, Q8BFR5
      Related
      ENSMUSP00000095656.5, ENSMUST00000098048.6
      Conserved Domains (4) summary
      cd01884
      Location:56 → 250
      EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins
      PRK00049
      Location:47 → 439
      PRK00049; elongation factor Tu; Reviewed
      cd03697
      Location:258 → 344
      EFTU_II; Domain II of elongation factor Tu
      cd03706
      Location:347 → 439
      mtEFTU_III; Domain III of mitochondrial EF-TU (mtEF-TU)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126086445..126089903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507719.5 → XP_006507782.1  elongation factor Tu, mitochondrial isoform X1

      Conserved Domains (1) summary
      PRK00049
      Location:47 → 411
      PRK00049; elongation factor Tu; Reviewed

    2. XM_036153012.1 → XP_036008905.1  elongation factor Tu, mitochondrial isoform X2

      Conserved Domains (1) summary
      PRK00049
      Location:1 → 303
      PRK00049; elongation factor Tu; Reviewed
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFR5.1 GenPept UniProtKB/Swiss-Prot:Q8BFR5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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