ARC5 P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ARC5
Official Full Name: P-loop containing nucleoside triphosphate hydrolases superfamily protein
Primary source: TAIR:AT3G19720
Locus tag: AT3G19720
See related: Araport:AT3G19720
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACCUMULATION AND REPLICATION OF CHLOROPLAST 5; DRP5B; Dynamin related protein 5B
Summary: Encodes a novel chloroplast division protein. Mutants of exhibit defects in chloroplast constriction, have enlarged, dumbbell-shaped chloroplasts. The ARC5 gene product shares similarity with the dynamin family of GTPases, which mediate endocytosis, mitochondrial division, and other organellar fission and fusion events in eukaryotes. Phylogenetic analysis showed that ARC5 is related to a group of dynamin-like proteins unique to plants. A GFP-ARC5 fusion protein localizes to a ring at the chloroplast division site. Chloroplast import and protease protection assays indicate that the ARC5 ring is positioned on the outer surface of the chloroplast. Facilitates separation of the two daughter chloroplasts.
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Genomic context

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See ARC5 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 18

Sequence:: Chromosome: 3; NC_003074.8 (6850358..6855590, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDV1 and PDV2 Differentially Affect Remodeling and Assembly of the Chloroplast DRP5B Ring.
Title: PDV1 and PDV2 Differentially Affect Remodeling and Assembly of the Chloroplast DRP5B Ring.
results support the notion that ARC5 is dispensable in the process of equal division of epidermal plastids, and indicate that dysfunctions in ARC5 and ARC6 differentially affect plastid replication among mesophyll cells, PCs, and GCs within a single leaf
Title: The Arabidopsis arc5 and arc6 mutations differentially affect plastid morphology in pavement and guard cells in the leaf epidermis.
The roles of DRP3A, DRP3B, and DRP5B in organelle division and plant development, were investigated.
Title: Differential roles of Arabidopsis dynamin-related proteins DRP3A, DRP3B, and DRP5B in organelle division.
Data indicate that that PDV1 and PDV2 inhibits DRP5B-mediated GTP hydrolysis in a ratio dependent manner.
Title: Plastid division control: the PDV proteins regulate DRP5B dynamin activity.
arc5 plastids appeared wild-type in the majority of nongreen tissues examined
Title: Effects of arc3, arc5 and arc6 mutations on plastid morphology and stromule formation in green and nongreen tissues of Arabidopsis thaliana.
ARC5, which encodes a cytosolic dynamin-like protein that is part of the chloroplast division machinery and arc mutants have large but fewer chloroplasts which have an effect on both the composition and structure of the photosynthetic apparatus. [ARC5]
Title: Photosynthesis in Arabidopsis thaliana mutants with reduced chloroplast number.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001203006.1

Supported by ESTs:

NM_112862.4

Supported by ESTs:

NM_180284.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloroplast fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloroplast fission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within peroxisome fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to gibberellin	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: P-loop containing nucleoside triphosphate hydrolases superfamily protein

NP_001189935.1

ACCUMULATION AND REPLICATION OF CHLOROPLAST 5 (ARC5); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: chloroplast fission, peroxisome fission; LOCATED IN: chloroplast outer membrane, peroxisome, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin, GTPase domain (InterPro:IPR001401); BEST Arabidopsis thaliana protein match is: Dynamin related protein 5A (TAIR:AT1G53140.1).

NP_188606.2

ACCUMULATION AND REPLICATION OF CHLOROPLAST 5 (ARC5); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: chloroplast fission, peroxisome fission; LOCATED IN: chloroplast outer membrane, peroxisome, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin, GTPase domain (InterPro:IPR001401); BEST Arabidopsis thaliana protein match is: Dynamin related protein 5A (TAIR:AT1G53140.1); Has 2186 Blast hits to 2177 proteins in 279 species: Archae - 0; Bacteria - 10; Metazoa - 945; Fungi - 507; Plants - 452; Viruses - 0; Other Eukaryotes - 272 (source: NCBI BLink).

NP_850615.2

ACCUMULATION AND REPLICATION OF CHLOROPLAST 5 (ARC5); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: chloroplast fission, peroxisome fission; LOCATED IN: chloroplast outer membrane, peroxisome, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin, GTPase domain (InterPro:IPR001401); BEST Arabidopsis thaliana protein match is: Dynamin related protein 5A (TAIR:AT1G53140.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

6850358..6855590 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_180284.3 → NP_850615.2 P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850615.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XDR2, A0A654F8U6, A0A7G2EM07

Conserved Domains (1) summary

cd08771
Location:49 → 343

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_112862.4 → NP_188606.2 P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_188606.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3EB39, Q84N64, Q9LJM3

UniProtKB/TrEMBL

A0A178VCF9, A0A7G2EM07

Conserved Domains (1) summary

cd08771
Location:49 → 343

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
NM_001203006.1 → NP_001189935.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189935.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2EM07, F4JCC8

Conserved Domains (1) summary

cd08771
Location:49 → 343

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins