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    Kif6 kinesin family member 6 [ Mus musculus (house mouse) ]

    Gene ID: 319991, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kif6provided by MGI
    Official Full Name
    kinesin family member 6provided by MGI
    Primary source
    MGI:MGI:1098238
    See related
    Ensembl:ENSMUSG00000023999 AllianceGenome:MGI:1098238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D130004B10Rik; D130084M03Rik
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in male germ cell nucleus. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in lateral ventricle choroid plexus and metencephalon part of 4th ventricle choroid plexus. Human ortholog(s) of this gene implicated in artery disease (multiple) and type 2 diabetes mellitus. Orthologous to human KIF6 (kinesin family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 1.1), heart adult (RPKM 0.4) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kif6 in Genome Data Viewer
    Location:
    17 C; 17 25.78 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (49922121..50216875)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (49615098..49909847)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:49568292-49568475 Neighboring gene STARR-positive B cell enhancer ABC_E1944 Neighboring gene molybdenum cofactor synthesis 1 Neighboring gene dishevelled associated activator of morphogenesis 2 Neighboring gene predicted gene, 52301 Neighboring gene VISTA enhancer mm276 Neighboring gene STARR-seq mESC enhancer starr_42779 Neighboring gene STARR-seq mESC enhancer starr_42780 Neighboring gene STARR-seq mESC enhancer starr_42781 Neighboring gene STARR-seq mESC enhancer starr_42782 Neighboring gene predicted gene 16555 Neighboring gene STARR-seq mESC enhancer starr_42783 Neighboring gene STARR-seq mESC enhancer starr_42784 Neighboring gene STARR-seq mESC enhancer starr_42785 Neighboring gene STARR-positive B cell enhancer mm9_chr17:50080531-50080832 Neighboring gene STARR-positive B cell enhancer mm9_chr17:50090914-50091215 Neighboring gene predicted gene, 19465 Neighboring gene STARR-positive B cell enhancer ABC_E7542 Neighboring gene raftlin lipid raft linker 1 Neighboring gene predicted gene, 52302

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Polarity in migrating neurons is related to a mechanism analogous to cytokinesis. Falnikar A, et al. Curr Biol, 2013 Jul 8. PMID 23791725, Free PMC Article
    2. No evidence for cardiac dysfunction in Kif6 mutant mice. Hameed A, et al. PLoS One, 2013. PMID 23355886, Free PMC Article
    3. Distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility. Fang C, et al. J Cell Biol, 2024 Nov 4. PMID 39158699,
    4. Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development. Konjikusic MJ, et al. PLoS Genet, 2018 Nov. PMID 30475797, Free PMC Article
    5. Sequence and expression of murine type I hair keratins mHa2 and mHa3. Winter H, et al. Exp Cell Res, 1994 Jun. PMID 7514534

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF6
    Names
    kinesin 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177052.4 → NP_796026.2  kinesin-like protein KIF6

      Status: VALIDATED

      Source sequence(s)
      AC114824, AC124748
      Consensus CDS
      CCDS50144.1
      UniProtKB/TrEMBL
      E9PX57
      Related
      ENSMUSP00000124674.2, ENSMUST00000162854.2
      Conserved Domains (3) summary
      cd01375
      Location:5 → 343
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:11 → 345
      Kinesin; Kinesin motor domain
      cl00920
      Location:350 → 408
      Cob_adeno_trans; Cobalamin adenosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      49922121..50216875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524391.5 → XP_006524454.1  kinesin-like protein KIF6 isoform X1

      Conserved Domains (2) summary
      cd01375
      Location:5 → 343
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      cl00920
      Location:350 → 408
      Cob_adeno_trans; Cobalamin adenosyltransferase

    2. XM_006524393.5 → XP_006524456.1  kinesin-like protein KIF6 isoform X3

      Conserved Domains (2) summary
      cl22853
      Location:5 → 343
      Motor_domain; Myosin and Kinesin motor domain
      cl00920
      Location:350 → 408
      Cob_adeno_trans; Cobalamin adenosyltransferase

    3. XM_011246494.3 → XP_011244796.1  kinesin-like protein KIF6 isoform X4

      Conserved Domains (3) summary
      TIGR00618
      Location:301 → 606
      sbcc; exonuclease SbcC
      cl22853
      Location:98 → 270
      Motor_domain; Myosin and Kinesin motor domain
      cl00920
      Location:277 → 335
      Cob_adeno_trans; Cobalamin adenosyltransferase

    4. XM_017317502.3 → XP_017172991.1  kinesin-like protein KIF6 isoform X2

      Conserved Domains (2) summary
      cl22853
      Location:10 → 184
      Motor_domain; Myosin and Kinesin motor domain
      cl00920
      Location:191 → 249
      Cob_adeno_trans; Cobalamin adenosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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