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    LTA3 Dihydrolipoamide acetyltransferase, long form protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824385, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LTA3
    Official Full Name
    Dihydrolipoamide acetyltransferase, long form protein
    Primary source
    TAIR:AT3G52200
    Locus tag
    AT3G52200
    See related
    Araport:AT3G52200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DIHYDROLIPOAMIDE S-ACETYLTRANSFERASE
    Summary
    dihydrolipoamide S-acetyltransferase (LTA3) mRNA, nuclear
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    Genomic context

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    See LTA3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    23
    Sequence:
    Chromosome: 3; NC_003074.8 (19360129..19366417)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene dual specificity protein phosphatase (DsPTP1) family protein Neighboring gene phosphate transporter traffic facilitator1 Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene leukocyte immunoglobulin-like receptor family A protein Neighboring gene uncharacterized protein Neighboring gene transcriptional regulator ATRX

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutation in the E2 subunit of the mitochondrial pyruvate dehydrogenase complex in Arabidopsis reduces plant organ size and enhances the accumulation of amino acids and intermediate products of the TCA cycle. Yu H, et al. Planta, 2012 Aug. PMID 22391856
    2. Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. Taylor NL, et al. Plant Physiol, 2004 Feb. PMID 14764908, Free PMC Article
    3. The impact of oxidative stress on Arabidopsis mitochondria. Sweetlove LJ, et al. Plant J, 2002 Dec. PMID 12492832
    4. Analysis of the soluble ATP-binding proteome of plant mitochondria identifies new proteins and nucleotide triphosphate interactions within the matrix. Ito J, et al. J Proteome Res, 2006 Dec. PMID 17137349
    5. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis mtE2-1 is a major contributor to the function of Arabidopsis mtPDC and that the functional disruption of mtE2-1 profoundly affects plant growth and development, as well as its metabolism.
      Title: A mutation in the E2 subunit of the mitochondrial pyruvate dehydrogenase complex in Arabidopsis reduces plant organ size and enhances the accumulation of amino acids and intermediate products of the TCA cycle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203141.1
    NM_115080.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables dihydrolipoyllysine-residue acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    part_of pyruvate dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of pyruvate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dihydrolipoamide acetyltransferase, long form protein
    NP_001190070.1
    • LTA3; FUNCTIONS IN: dihydrolipoyllysine-residue acetyltransferase activity; INVOLVED IN: pyruvate metabolic process, metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), Dihydrolipoamide acetyltransferase, long form (InterPro:IPR006257), E3 binding (InterPro:IPR004167), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: Dihydrolipoamide acetyltransferase, long form protein (TAIR:AT1G54220.2).
    NP_190788.1
    • LTA3; FUNCTIONS IN: dihydrolipoyllysine-residue acetyltransferase activity, ATP binding; INVOLVED IN: pyruvate metabolic process, metabolic process, acetyl-CoA biosynthetic process from pyruvate; LOCATED IN: mitochondrion; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), Dihydrolipoamide acetyltransferase, long form (InterPro:IPR006257), E3 binding (InterPro:IPR004167), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: Dihydrolipoamide acetyltransferase, long form protein (TAIR:AT1G54220.2); Has 31247 Blast hits to 19646 proteins in 2349 species: Archae - 188; Bacteria - 18229; Metazoa - 1059; Fungi - 783; Plants - 619; Viruses - 0; Other Eukaryotes - 10369 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19360129..19366417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115080.3 → NP_190788.1  Dihydrolipoamide acetyltransferase, long form protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190788.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WQF7, Q39082, Q9SQI7, Q9SUY5
      UniProtKB/TrEMBL
      A0A5S9XKV9, A0A654FFZ5
      Conserved Domains (2) summary
      PRK11892
      Location:90 → 173
      PRK11892; pyruvate dehydrogenase subunit beta; Provisional
      TIGR01349
      Location:214 → 637
      PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form

    2. NM_001203141.1 → NP_001190070.1  Dihydrolipoamide acetyltransferase, long form protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190070.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XKV9, A0A654FFZ5, F4J5T2
      Conserved Domains (4) summary
      cd06849
      Location:166 → 236
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01349
      Location:290 → 713
      PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
      pfam00198
      Location:499 → 713
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
      pfam02817
      Location:406 → 439
      E3_binding; e3 binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WQF7.2

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