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    Rnf157 ring finger protein 157 [ Mus musculus (house mouse) ]

    Gene ID: 217340, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf157provided by MGI
    Official Full Name
    ring finger protein 157provided by MGI
    Primary source
    MGI:MGI:2442484
    See related
    Ensembl:ENSMUSG00000052949 AllianceGenome:MGI:2442484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1917; 2610036E23Rik; A130073L17Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of apoptotic process; positive regulation of dendrite extension; and protein ubiquitination. Predicted to be located in cell body. Predicted to be active in cytoplasm. Is expressed in future spinal cord. Orthologous to human RNF157 (ring finger protein 157). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 39.1), cortex adult (RPKM 38.6) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf157 in Genome Data Viewer
    Location:
    11 E2; 11 81.17 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116227179..116303859, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116336345..116413391, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26730 Neighboring gene STARR-seq mESC enhancer starr_31197 Neighboring gene STARR-seq mESC enhancer starr_31198 Neighboring gene forkhead box J1 Neighboring gene STARR-positive B cell enhancer ABC_E5299 Neighboring gene ribosomal protein S11, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr11:116255636-116255937 Neighboring gene STARR-positive B cell enhancer ABC_E9382 Neighboring gene STARR-positive B cell enhancer ABC_E8472 Neighboring gene STARR-positive B cell enhancer ABC_E5300 Neighboring gene STARR-positive B cell enhancer ABC_E10733 Neighboring gene STARR-seq mESC enhancer starr_31202 Neighboring gene STARR-seq mESC enhancer starr_31205 Neighboring gene UBA-like domain containing 2 Neighboring gene glutamine rich 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNF157 attenuates CD4(+) T cell-mediated autoimmune response by promoting HDAC1 ubiquitination and degradation. Wang P, et al. Theranostics, 2023. PMID 37441600, Free PMC Article
    2. A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development. Kong JH, et al. Dev Cell, 2020 Nov 23. PMID 32966817, Free PMC Article
    3. Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157. Matz A, et al. Cell Death Differ, 2015 Apr. PMID 25342469, Free PMC Article
    4. Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord. Masuda T, et al. Brain Res, 2009 Jan 16. PMID 19026994
    5. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF157 attenuates CD4[+] T cell-mediated autoimmune response by promoting HDAC1 ubiquitination and degradation.
      Title: RNF157 attenuates CD4(+) T cell-mediated autoimmune response by promoting HDAC1 ubiquitination and degradation.
    2. RNF157 has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical.
      Title: Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite extension ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin ligase Rnf157
    Names
    RING-type E3 ubiquitin transferase Rnf157
    NP_001392066.1
    NP_001392067.1
    NP_001392068.1
    NP_001392069.1
    NP_001392070.1
    NP_001392071.1
    NP_001392072.1
    NP_001392073.1
    NP_001392074.1
    NP_081534.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405137.1 → NP_001392066.1  E3 ubiquitin ligase Rnf157 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645861
      UniProtKB/TrEMBL
      A2AAP0

    2. NM_001405138.1 → NP_001392067.1  E3 ubiquitin ligase Rnf157 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645861
      UniProtKB/Swiss-Prot
      Q3TEL6, Q80T75

    3. NM_001405139.1 → NP_001392068.1  E3 ubiquitin ligase Rnf157 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645861
      UniProtKB/Swiss-Prot
      Q3TEL6, Q80T75

    4. NM_001405140.1 → NP_001392069.1  E3 ubiquitin ligase Rnf157 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL645861
      UniProtKB/Swiss-Prot
      Q3TEL6, Q80T75

    5. NM_001405141.1 → NP_001392070.1  E3 ubiquitin ligase Rnf157 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL645861
      UniProtKB/Swiss-Prot
      Q3TEL6, Q80T75

    6. NM_001405142.1 → NP_001392071.1  E3 ubiquitin ligase Rnf157 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL645861
      UniProtKB/TrEMBL
      A2AAP0

    7. NM_001405143.1 → NP_001392072.1  E3 ubiquitin ligase Rnf157 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL645861
      UniProtKB/Swiss-Prot
      Q3TEL6, Q80T75

    8. NM_001405144.1 → NP_001392073.1  E3 ubiquitin ligase Rnf157 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL645861
      UniProtKB/Swiss-Prot
      Q3TEL6, Q80T75

    9. NM_001405145.1 → NP_001392074.1  E3 ubiquitin ligase Rnf157 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL645861
      UniProtKB/Swiss-Prot
      Q3TEL6, Q80T75

    10. NM_027258.2 → NP_081534.1  E3 ubiquitin ligase Rnf157 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645861
      Consensus CDS
      CCDS48984.1
      UniProtKB/TrEMBL
      A2AAN9, A2AAP0
      Related
      ENSMUSP00000097776.4, ENSMUST00000100202.10
      Conserved Domains (1) summary
      pfam13920
      Location:276 → 318
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116227179..116303859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TEL6.2 GenPept UniProtKB/Swiss-Prot:Q3TEL6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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