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    Lrrc19 leucine rich repeat containing 19 [ Mus musculus (house mouse) ]

    Gene ID: 100061, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrrc19provided by MGI
    Official Full Name
    leucine rich repeat containing 19provided by MGI
    Primary source
    MGI:MGI:2140219
    See related
    Ensembl:ENSMUSG00000049799 AllianceGenome:MGI:2140219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130022A01Rik
    Summary
    Enables signaling receptor activity. Involved in several processes, including host-mediated regulation of intestinal microbiota composition; positive regulation of canonical NF-kappaB signal transduction; and regulation of inflammatory response. Acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction and toll-like receptor signaling pathway. Located in plasma membrane. Orthologous to human LRRC19 (leucine rich repeat containing 19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 14.5), large intestine adult (RPKM 4.0) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc19 in Genome Data Viewer
    Location:
    4 C5; 4 43.34 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (94523958..94538381, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (94635721..94650144, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10788 Neighboring gene caspase activity and apoptosis inhibitor 1 Neighboring gene phospholipase A2, activating protein Neighboring gene STARR-positive B cell enhancer ABC_E3497 Neighboring gene H3.5 histone Neighboring gene intraflagellar transport 74 Neighboring gene STARR-seq mESC enhancer starr_10791 Neighboring gene microRNA 872 Neighboring gene predicted gene, 40205

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-ζ and PKCι/λ to Reduce Expression of ZO1, ZO3, and Occludin. Su X, et al. Inflamm Bowel Dis, 2021 Jul 27. PMID 33501933
    2. Suppression of LRRC19 promotes cutaneous wound healing in pressure ulcers in mice. Sun J, et al. Organogenesis, 2018 Jan 2. PMID 29461900, Free PMC Article
    3. Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis. Xie R, et al. Microbiome, 2024 Jan 3. PMID 38172943, Free PMC Article
    4. LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria. Su X, et al. Nat Commun, 2014 Jul 16. PMID 25026888
    5. LRRC19, a novel member of the leucine-rich repeat protein family, activates NF-kappaB and induces expression of proinflammatory cytokines. Chai L, et al. Biochem Biophys Res Commun, 2009 Oct 23. PMID 19679103

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis.
      Title: Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis.
    2. LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-zeta and PKCiota/lambda to Reduce Expression of ZO1, ZO3, and Occludin.
      Title: LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-ζ and PKCι/λ to Reduce Expression of ZO1, ZO3, and Occludin.
    3. LRRC19 could be a potential therapeutic target for pressure ulcers.
      Title: Suppression of LRRC19 promotes cutaneous wound healing in pressure ulcers in mice.
    4. LRRC19 deficiency impairs the gut immune system and host-microbiota interactions.
      Title: The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation.
    5. LRRC19 may play an important role in inducing innate immune responses in certain tissues such as the kidney.
      Title: LRRC19, a novel member of the leucine-rich repeat protein family, activates NF-kappaB and induces expression of proinflammatory cytokines.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in host-mediated regulation of intestinal microbiota composition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within toll-like receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356281.1 → NP_001343210.1  leucine-rich repeat-containing protein 19 precursor

      Status: VALIDATED

      Source sequence(s)
      AK033594, AK165421, AL732597
      Consensus CDS
      CCDS18360.1
      UniProtKB/Swiss-Prot
      B1AWG3, Q6P8J1, Q8BZT5
      Related
      ENSMUSP00000102718.2, ENSMUST00000107101.2
      Conserved Domains (4) summary
      smart00082
      Location:174 → 211
      LRRCT; Leucine rich repeat C-terminal domain
      sd00031
      Location:73 → 96
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:96 → 155
      LRR_8; Leucine rich repeat
      pfam15176
      Location:251 → 364
      LRR19-TM; Leucine-rich repeat family 19 TM domain

    2. NM_175305.5 → NP_780514.1  leucine-rich repeat-containing protein 19 precursor

      See identical proteins and their annotated locations for NP_780514.1

      Status: VALIDATED

      Source sequence(s)
      AK033594, AK165421
      Consensus CDS
      CCDS18360.1
      UniProtKB/Swiss-Prot
      B1AWG3, Q6P8J1, Q8BZT5
      Related
      ENSMUSP00000056094.3, ENSMUST00000053419.9
      Conserved Domains (4) summary
      smart00082
      Location:174 → 211
      LRRCT; Leucine rich repeat C-terminal domain
      sd00031
      Location:73 → 96
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:96 → 155
      LRR_8; Leucine rich repeat
      pfam15176
      Location:251 → 364
      LRR19-TM; Leucine-rich repeat family 19 TM domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      94523958..94538381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502614.4 → XP_006502677.1  leucine-rich repeat-containing protein 19 isoform X1

      See identical proteins and their annotated locations for XP_006502677.1

      UniProtKB/Swiss-Prot
      B1AWG3, Q6P8J1, Q8BZT5
      Conserved Domains (4) summary
      smart00082
      Location:174 → 211
      LRRCT; Leucine rich repeat C-terminal domain
      sd00031
      Location:73 → 96
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:96 → 155
      LRR_8; Leucine rich repeat
      pfam15176
      Location:251 → 364
      LRR19-TM; Leucine-rich repeat family 19 TM domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZT5.1 GenPept UniProtKB/Swiss-Prot:Q8BZT5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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