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    Wdr76 WD repeat domain 76 [ Mus musculus (house mouse) ]

    Gene ID: 241627, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Wdr76provided by MGI
    Official Full Name
    WD repeat domain 76provided by MGI
    Primary source
    MGI:MGI:1926186
    See related
    Ensembl:ENSMUSG00000027242 AllianceGenome:MGI:1926186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030457D09; 5830411K18Rik
    Summary
    Predicted to enable DNA binding activity and enzyme binding activity. Predicted to be involved in DNA damage response and regulation of DNA damage checkpoint. Predicted to be located in heterochromatin and site of DNA damage. Predicted to be active in nucleus. Orthologous to human WDR76 (WD repeat domain 76). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 5.6), CNS E11.5 (RPKM 5.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wdr76 in Genome Data Viewer
    Location:
    2 E5; 2 60.41 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121337204..121375341)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121506723..121544860)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene WD repeat domain 76 pseudogene Neighboring gene mitochondrial ribosomal protein L51 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:121332344-121332527 Neighboring gene STARR-seq mESC enhancer starr_05528 Neighboring gene microfibrillar-associated protein 1A Neighboring gene STARR-seq mESC enhancer starr_05532 Neighboring gene FERM domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_05533 Neighboring gene STARR-seq mESC enhancer starr_05535 Neighboring gene STARR-seq mESC enhancer starr_05536 Neighboring gene septin 2 pseudogene Neighboring gene ribosomal protein S4, X-linked pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. WDR76 mediates obesity and hepatic steatosis via HRas destabilization. Park JC, et al. Sci Rep, 2019 Dec 23. PMID 31873167, Free PMC Article
    2. WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation. Jeong WJ, et al. Nat Commun, 2019 Jan 17. PMID 30655611, Free PMC Article
    3. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA damage checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in heterochromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 76

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290986.1 → NP_001277915.1  WD repeat-containing protein 76 isoform a

      See identical proteins and their annotated locations for NP_001277915.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK031592, BC094676, BY720216
      Consensus CDS
      CCDS38218.1
      UniProtKB/Swiss-Prot
      A6PWY4
      Related
      ENSMUSP00000106232.3, ENSMUST00000110602.9
      Conserved Domains (3) summary
      COG2319
      Location:214 → 484
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:218 → 258
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:214 → 423
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001290987.1 → NP_001277916.1  WD repeat-containing protein 76 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK031592, BC094676, BY720216
      UniProtKB/Swiss-Prot
      A6PWY4
      Conserved Domains (3) summary
      COG2319
      Location:60 → 330
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:60 → 269
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001369185.1 → NP_001356114.1  WD repeat-containing protein 76 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This isoform encodes the longest isoform (c).
      Source sequence(s)
      AL928678
      Consensus CDS
      CCDS89546.1
      UniProtKB/Swiss-Prot
      A2ASQ8, A4FUV0, A6PWY4, Q504Z3, Q9CTV4
      Related
      ENSMUSP00000106234.2, ENSMUST00000110603.2
      Conserved Domains (2) summary
      sd00039
      Location:316 → 356
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:312 → 521
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_030234.2 → NP_084510.2  WD repeat-containing protein 76 isoform a

      See identical proteins and their annotated locations for NP_084510.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK031592, AK162181, BC094676, BY019145
      Consensus CDS
      CCDS38218.1
      UniProtKB/Swiss-Prot
      A6PWY4
      Related
      ENSMUSP00000028676.6, ENSMUST00000028676.12
      Conserved Domains (3) summary
      COG2319
      Location:214 → 484
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:218 → 258
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:214 → 423
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121337204..121375341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239529.3 → XP_011237831.1  WD repeat-containing protein 76 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6PWY4.1 GenPept UniProtKB/Swiss-Prot:A6PWY4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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