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    Bhlhb9 basic helix-loop-helix domain containing, class B9 [ Mus musculus (house mouse) ]

    Gene ID: 70237, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bhlhb9provided by MGI
    Official Full Name
    basic helix-loop-helix domain containing, class B9provided by MGI
    Primary source
    MGI:MGI:1917487
    See related
    Ensembl:ENSMUSG00000072964 AllianceGenome:MGI:1917487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gprasp3; 2700087I09Rik
    Summary
    Enables protein homodimerization activity. Involved in learning or memory; negative regulation of neuron apoptotic process; and positive regulation of nervous system development. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; sensory organ; skeleton; submandibular gland primordium; and trigeminal nerve. Orthologous to several human genes including GPRASP3 (G protein-coupled receptor associated sorting protein family member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 18.6), CNS E14 (RPKM 15.2) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bhlhb9 in Genome Data Viewer
    Location:
    X F1; X 57.31 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134742388..134791828)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (135841639..135891081)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor associated sorting protein 1 Neighboring gene RAB18, member RAS oncogene family pseudogene Neighboring gene microRNA 1970 Neighboring gene STARR-seq mESC enhancer starr_47971 Neighboring gene G protein-coupled receptor associated sorting protein 2 Neighboring gene STARR-seq mESC enhancer starr_47972 Neighboring gene predicted gene, 31214 Neighboring gene adipocyte-related X-chromosome expressed sequence 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Brain-site-specific proteome changes induced by neuronal P60TRP expression. Manavalan A, et al. Neurosignals, 2013. PMID 23391701
    2. Neuronal p60TRP expression modulates cardiac capacity. Mishra M, et al. J Proteomics, 2012 Feb 16. PMID 22172954
    3. P60TRP interferes with the GPCR/secretase pathway to mediate neuronal survival and synaptogenesis. Mishra M, et al. J Cell Mol Med, 2011 Nov. PMID 21199326, Free PMC Article
    4. A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Zhou J, et al. Biol Reprod, 2013 Jun. PMID 23677977, Free PMC Article
    5. A genomic atlas of mouse hypothalamic development. Shimogori T, et al. Nat Neurosci, 2010 Jun. PMID 20436479, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in learning or memory IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of dendritic spine morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neurogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G protein-coupled receptor associated sorting protein 3
    Names
    protein BHLHB9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098222.2 → NP_001091692.1  G protein-coupled receptor associated sorting protein 3

      See identical proteins and their annotated locations for NP_001091692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL683822
      Consensus CDS
      CCDS30410.1
      UniProtKB/Swiss-Prot
      Q3U0C1, Q69ZD0, Q6PB60
      Related
      ENSMUSP00000137213.2, ENSMUST00000180025.8
      Conserved Domains (1) summary
      pfam04826
      Location:306 → 533
      Arm_2; Armadillo-like

    2. NM_198161.3 → NP_937804.1  G protein-coupled receptor associated sorting protein 3

      See identical proteins and their annotated locations for NP_937804.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL683822
      Consensus CDS
      CCDS30410.1
      UniProtKB/Swiss-Prot
      Q3U0C1, Q69ZD0, Q6PB60
      Related
      ENSMUSP00000068067.8, ENSMUST00000068755.14
      Conserved Domains (1) summary
      pfam04826
      Location:306 → 533
      Arm_2; Armadillo-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      134742388..134791828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247760.1 → XP_011246062.1  G protein-coupled receptor associated sorting protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011246062.1

      UniProtKB/Swiss-Prot
      Q3U0C1, Q69ZD0, Q6PB60
      Conserved Domains (1) summary
      pfam04826
      Location:306 → 533
      Arm_2; Armadillo-like

    2. XM_006528608.3 → XP_006528671.1  G protein-coupled receptor associated sorting protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006528671.1

      UniProtKB/Swiss-Prot
      Q3U0C1, Q69ZD0, Q6PB60
      Conserved Domains (1) summary
      pfam04826
      Location:306 → 533
      Arm_2; Armadillo-like

    3. XM_036162091.1 → XP_036017984.1  G protein-coupled receptor associated sorting protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q3U0C1, Q69ZD0, Q6PB60
      Conserved Domains (1) summary
      pfam04826
      Location:306 → 533
      Arm_2; Armadillo-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PB60.1 GenPept UniProtKB/Swiss-Prot:Q6PB60

    Gene LinkOut

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