Slc2a9 solute carrier family 2 (facilitated glucose transporter), member 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc2a9provided by MGI
Official Full Name: solute carrier family 2 (facilitated glucose transporter), member 9provided by MGI
Primary source: MGI:MGI:2152844
See related: Ensembl:ENSMUSG00000005107 AllianceGenome:MGI:2152844
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glut9; GLUT-9; SLC2A9B; SLC2a9A
Summary: Enables D-glucose transmembrane transporter activity and urate transmembrane transporter activity. Involved in urate transport. Acts upstream of or within D-glucose transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including early conceptus; heart; liver; metanephros; and thymus primordium. Used to study abdominal obesity-metabolic syndrome and hyperuricemia. Orthologous to human SLC2A9 (solute carrier family 2 member 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver adult (RPKM 6.8), large intestine adult (RPKM 5.0) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 20.43 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (38506616..38660488, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (38349272..38503147, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
Title: METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid level and metabolic associated fatty liver disease.
Title: The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid level and metabolic associated fatty liver disease.
Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System.
Title: Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System.
MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells in hyperuricemia.
Title: MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.
these data show that GLUT6 is dispensable for lipopolysaccharide-induced M1 polarization and function
Title: Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow-Derived Macrophage Function.
SLC2A9 regulates urate reabsorption in the mouse kidney.
Title: SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney.
Its anti-hyperuricemic mechanisms may be ascribed to its inhibition of XOD and its up-regulation of organic anion transporter 1 (OAT1) and down-regulation of glucose transporter 9 (GLUT9).
Title: Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD.
intestinal uric acid transporter SLC2A9 has a role in early-onset metabolic syndrome in a mouse model
Title: Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9.
Studies confirm the expression of GLUT9a and GLUT9b in murine and human beta-cells.
Title: Facilitative glucose transporter 9 expression affects glucose sensing in pancreatic beta-cells.
Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.
Title: Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Markers

D5Dmo4 (e-PCR), detects polymorphism
- UniSTS:233992

Slc2a9 (e-PCR), detects polymorphism
- UniSTS:275874

Slc2a9 (e-PCR), detects polymorphism
- UniSTS:275875

Slc2a9 (e-PCR), detects polymorphism
- UniSTS:275876

NoName (e-PCR)
- UniSTS:224459

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fructose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables urate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables urate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables urate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in D-glucose import	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in dehydroascorbic acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose transmembrane transport	ISO Inferred from Sequence Orthology more info
NOT involved_in fructose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in urate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in urate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in urate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in urate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urate transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 9

Names: facilitated glucose transporter, type 9; glucose transporter type 9; urate transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012363.2 → NP_001012363.2 solute carrier family 2, facilitated glucose transporter member 9 isoform 2

See identical proteins and their annotated locations for NP_001012363.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' CDS, compared to variant 1. The encoded protein (isoform 2, also known as the long form of mGLUT9b) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC171271, AK033725, AY776155

Consensus CDS

CCDS51484.1

UniProtKB/TrEMBL

B9EHN5, Q5ERC7, Q8BZR3

Related

ENSMUSP00000066872.6, ENSMUST00000067872.12

Conserved Domains (1) summary

cd17432
Location:25 → 476

MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
NM_001102414.1 → NP_001095884.1 solute carrier family 2, facilitated glucose transporter member 9 isoform 1

See identical proteins and their annotated locations for NP_001095884.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1, also known as the long form of mGLUT9a).

Source sequence(s)

AC171271, AK156740

Consensus CDS

CCDS51483.1

UniProtKB/Swiss-Prot

A0A0J9YUW8, B7ZNE4, B9EHN5, D3Z1X2, D6REU9, Q3T9X0, Q5ERC7, Q7TSK9, Q7TSP0, Q8BZR3, Q99JJ2

Related

ENSMUSP00000063352.6, ENSMUST00000067886.12

Conserved Domains (1) summary

cd17432
Location:40 → 491

MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
NM_001102415.1 → NP_001095885.1 solute carrier family 2, facilitated glucose transporter member 9 isoform 3

See identical proteins and their annotated locations for NP_001095885.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform 3, also known as the short form of mGLUT9a) lacks an internal region and is shorter, compared to isoform 1.

Source sequence(s)

AC084071, AC171271, AF490463

Consensus CDS

CCDS51482.1

UniProtKB/TrEMBL

Q7TSK9

Related

ENSMUSP00000118430.2, ENSMUST00000143758.8

Conserved Domains (2) summary

cd06174
Location:42 → 372

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:40 → 388

Sugar_tr; Sugar (and other) transporter
NM_145559.2 → NP_663534.1 solute carrier family 2, facilitated glucose transporter member 9 isoform 4

See identical proteins and their annotated locations for NP_663534.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and CDS, and lacks two alternate in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform 4, also known as the short form of mGLUT9b) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC084071, BC006076

Consensus CDS

CCDS19256.1

UniProtKB/TrEMBL

Q99JJ2

Related

ENSMUSP00000005238.7, ENSMUST00000005238.13

Conserved Domains (1) summary

cl28910
Location:25 → 369

MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

38506616..38660488 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503687.5 → XP_006503750.1 solute carrier family 2, facilitated glucose transporter member 9 isoform X2

See identical proteins and their annotated locations for XP_006503750.1

UniProtKB/TrEMBL

Q99JJ2

Conserved Domains (1) summary

cl28910
Location:25 → 369

MFS; Major Facilitator Superfamily
XM_006503685.5 → XP_006503748.1 solute carrier family 2, facilitated glucose transporter member 9 isoform X1

See identical proteins and their annotated locations for XP_006503748.1

UniProtKB/TrEMBL

B9EHN5

Related

ENSMUSP00000116354.2, ENSMUST00000155634.8

Conserved Domains (1) summary

cd17432
Location:25 → 476

MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
XM_006503684.5 → XP_006503747.1 solute carrier family 2, facilitated glucose transporter member 9 isoform X1

See identical proteins and their annotated locations for XP_006503747.1

UniProtKB/TrEMBL

B9EHN5

Conserved Domains (1) summary

cd17432
Location:25 → 476

MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
XM_011240690.3 → XP_011238992.1 solute carrier family 2, facilitated glucose transporter member 9 isoform X1

See identical proteins and their annotated locations for XP_011238992.1

UniProtKB/TrEMBL

B9EHN5

Conserved Domains (1) summary

cd17432
Location:25 → 476

MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
XM_011240689.4 → XP_011238991.1 solute carrier family 2, facilitated glucose transporter member 9 isoform X1

See identical proteins and their annotated locations for XP_011238991.1

UniProtKB/TrEMBL

B9EHN5

Conserved Domains (1) summary

cd17432
Location:25 → 476

MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
XM_006503686.5 → XP_006503749.1 solute carrier family 2, facilitated glucose transporter member 9 isoform X2

See identical proteins and their annotated locations for XP_006503749.1

UniProtKB/TrEMBL

Q99JJ2

Conserved Domains (1) summary

cl28910
Location:25 → 369

MFS; Major Facilitator Superfamily
XM_006503683.5 → XP_006503746.1 solute carrier family 2, facilitated glucose transporter member 9 isoform X1

See identical proteins and their annotated locations for XP_006503746.1

UniProtKB/TrEMBL

B9EHN5

Related

ENSMUSP00000122723.2, ENSMUST00000129099.8

Conserved Domains (1) summary

cd17432
Location:25 → 476

MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
XM_030254075.2 → XP_030109935.1 solute carrier family 2, facilitated glucose transporter member 9 isoform X1

Conserved Domains (1) summary

cd17432
Location:25 → 476

MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily