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    Rbbp6 retinoblastoma binding protein 6, ubiquitin ligase [ Mus musculus (house mouse) ]

    Gene ID: 19647, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rbbp6provided by MGI
    Official Full Name
    retinoblastoma binding protein 6, ubiquitin ligaseprovided by MGI
    Primary source
    MGI:MGI:894835
    See related
    Ensembl:ENSMUSG00000030779 AllianceGenome:MGI:894835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PACT; P2P-R; 4933422O15Rik; C030034J04Rik
    Summary
    Predicted to enable protein kinase binding activity and ubiquitin protein ligase activity. Involved in ubiquitin-dependent protein catabolic process. Acts upstream of or within embryonic organ development; in utero embryonic development; and somite development. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with centrosome. Is expressed in lung; tongue; and upper jaw. Orthologous to human RBBP6 (RB binding protein 6, ubiquitin ligase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.8), CNS E14 (RPKM 9.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbbp6 in Genome Data Viewer
    Location:
    7 F2; 7 67.42 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (122568980..122601780)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (122969637..123002572)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39082 Neighboring gene predicted gene, 39083 Neighboring gene RIKEN cDNA 4930413G21 gene Neighboring gene STARR-positive B cell enhancer ABC_E9705 Neighboring gene ribosomal protein L11 pseudogene Neighboring gene predicted gene, 51498

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. P2P-R protein overexpression restricts mitotic progression at prometaphase and promotes mitotic apoptosis. Gao S, et al. J Cell Physiol, 2002 Nov. PMID 12384997
    2. Stable overexpression of specific segments of the P2P-R protein in human MCF-7 cells promotes camptothecin-induced apoptosis. Gao S, et al. J Cell Physiol, 2003 Dec. PMID 14566974
    3. The proliferation potential protein-related (P2P-R) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation. Witte MM, et al. Proc Natl Acad Sci U S A, 1997 Feb 18. PMID 9037032, Free PMC Article
    4. P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity. Gao S, et al. J Cell Physiol, 2002 May. PMID 12064457
    5. Unveiling dysregulated lncRNAs and networks in non-syndromic cleft lip with or without cleft palate pathogenesis. Wu C, et al. Sci Rep, 2024 Jan 10. PMID 38200098, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the PACT-p53 interaction plays a critical role in embryonic development and tumorigenesis and identify PACT as a member of negative regulators of p53.
      Title: PACT is a negative regulator of p53 and essential for cell growth and embryonic development.
    2. P2P-R expression may be translationally regulated by PUM2 and that P2P-R may modulate translation by influencing ribosomal protein gene expression
      Title: P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC32263

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic organ development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within somite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RBBP6
    Names
    RING-type E3 ubiquitin transferase RBBP6
    p53-associated cellular protein of testis
    proliferation potential-related protein
    protein P2P-R
    retinoblastoma-binding protein 6
    NP_001390011.1
    NP_001390012.1
    NP_035377.2
    NP_778188.1
    XP_030098102.1
    XP_036008697.1
    XP_036008698.1
    XP_036008699.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403082.1 → NP_001390011.1  E3 ubiquitin-protein ligase RBBP6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125221
      Related
      ENSMUSP00000155989.2, ENSMUST00000231323.2

    2. NM_001403083.1 → NP_001390012.1  E3 ubiquitin-protein ligase RBBP6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC125221
      Related
      ENSMUSP00000071519.6, ENSMUST00000071590.6

    3. NM_011247.3 → NP_035377.2  E3 ubiquitin-protein ligase RBBP6 isoform 1

      See identical proteins and their annotated locations for NP_035377.2

      Status: VALIDATED

      Source sequence(s)
      AC125221
      Consensus CDS
      CCDS52387.1
      UniProtKB/Swiss-Prot
      P70287, P97868, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399
      UniProtKB/TrEMBL
      A0A338P6W1
      Related
      ENSMUSP00000049528.8, ENSMUST00000052135.14
      Conserved Domains (5) summary
      smart00184
      Location:260 → 300
      RING; Ring finger
      COG5222
      Location:2 → 420
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      pfam08783
      Location:4 → 75
      DWNN; DWNN domain
      pfam13696
      Location:157 → 177
      zf-CCHC_2; Zinc knuckle
      cl10727
      Location:992 → 1160
      DUF2042; Uncharacterized conserved protein (DUF2042)

    4. NM_175023.4 → NP_778188.1  E3 ubiquitin-protein ligase RBBP6 isoform 2

      See identical proteins and their annotated locations for NP_778188.1

      Status: VALIDATED

      Source sequence(s)
      AC125221
      Consensus CDS
      CCDS21817.1
      UniProtKB/TrEMBL
      A0A0R4J165
      Related
      ENSMUSP00000095670.3, ENSMUST00000098062.9
      Conserved Domains (1) summary
      pfam08783
      Location:4 → 75
      DWNN; DWNN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      122568980..122601780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152805.1 → XP_036008698.1  E3 ubiquitin-protein ligase RBBP6 isoform X4

      UniProtKB/TrEMBL
      A0A338P6W1
      Conserved Domains (2) summary
      PTZ00121
      Location:811 → 1455
      PTZ00121; MAEBL; Provisional
      COG5222
      Location:21 → 325
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

    2. XM_036152806.1 → XP_036008699.1  E3 ubiquitin-protein ligase RBBP6 isoform X5

      UniProtKB/TrEMBL
      A0A338P6W1
      Conserved Domains (2) summary
      PTZ00121
      Location:773 → 1417
      PTZ00121; MAEBL; Provisional
      COG5222
      Location:21 → 287
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

    3. XM_030242242.2 → XP_030098102.1  E3 ubiquitin-protein ligase RBBP6 isoform X6

      UniProtKB/TrEMBL
      A0A338P6W1
      Conserved Domains (2) summary
      PTZ00121
      Location:739 → 1383
      PTZ00121; MAEBL; Provisional
      COG5222
      Location:21 → 287
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

    4. XM_036152804.1 → XP_036008697.1  E3 ubiquitin-protein ligase RBBP6 isoform X2

      UniProtKB/TrEMBL
      A0A338P6W1
      Conserved Domains (2) summary
      PTZ00121
      Location:910 → 1554
      PTZ00121; MAEBL; Provisional
      COG5222
      Location:2 → 458
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97868.5 GenPept UniProtKB/Swiss-Prot:P97868

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