Gpr19 G protein-coupled receptor 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr19provided by MGI
Official Full Name: G protein-coupled receptor 19provided by MGI
Primary source: MGI:MGI:892973
See related: Ensembl:ENSMUSG00000032641 AllianceGenome:MGI:892973
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cilium and neuron projection. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Orthologous to human GPR19 (G protein-coupled receptor 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 6.5), whole brain E14.5 (RPKM 5.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G1; 6 65.77 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (134846055..134875157, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (134869092..134898194, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ontogeny of adropin and its receptor expression during postnatal development and its pro-gonadal role in the ovary of pre-pubertal mouse.
Title: Ontogeny of adropin and its receptor expression during postnatal development and its pro-gonadal role in the ovary of pre-pubertal mouse.
G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction.
Title: G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction.
Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock.
Title: Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (3)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235565

UniSTS:495943 (e-PCR)
- UniSTS:495943

Gpr19 (e-PCR), detects polymorphism
- UniSTS:495943

RH138678 (e-PCR)
- UniSTS:220765

Gpr19 (e-PCR), detects polymorphism
- UniSTS:143243

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable G-protein coupled receptor 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167694.2 → NP_001161166.1 probable G-protein coupled receptor 19 isoform a

See identical proteins and their annotated locations for NP_001161166.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longer isoform (a). Variants 3, 6 and 7 all encode isoform a.

Source sequence(s)

AC122193, AK140770, BY712856, DV660907

Consensus CDS

CCDS51937.1

UniProtKB/Swiss-Prot

Q61121, Q810I4, Q8VDJ9

UniProtKB/TrEMBL

A0A1L1SSP1

Related

ENSMUSP00000047630.8, ENSMUST00000046255.14

Conserved Domains (1) summary

cd15008
Location:67 → 341

7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001167695.2 → NP_001161167.1 probable G-protein coupled receptor 19 isoform b

See identical proteins and their annotated locations for NP_001161167.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 1, 2, 4, 5, and 8-12 all encode isoform b.

Source sequence(s)

AC122193, AK140770

Consensus CDS

CCDS20641.1

UniProtKB/TrEMBL

A0A1L1SSP1

Conserved Domains (1) summary

cd15008
Location:61 → 335

7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001167696.2 → NP_001161168.1 probable G-protein coupled receptor 19 isoform b

See identical proteins and their annotated locations for NP_001161168.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 1, 2, 4, 5, and 8-12 all encode isoform b.

Source sequence(s)

AC122193, AK132917, DV651999

Consensus CDS

CCDS20641.1

UniProtKB/TrEMBL

A0A1L1SSP1

Related

ENSMUSP00000127876.2, ENSMUST00000165392.8

Conserved Domains (1) summary

cd15008
Location:61 → 335

7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001167697.2 → NP_001161169.1 probable G-protein coupled receptor 19 isoform a

See identical proteins and their annotated locations for NP_001161169.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 3. Variants 3, 6 and 7 all encode isoform a.

Source sequence(s)

AC122193, AK132917, BB853775, BQ558507

Consensus CDS

CCDS51937.1

UniProtKB/Swiss-Prot

Q61121, Q810I4, Q8VDJ9

UniProtKB/TrEMBL

A0A1L1SSP1

Conserved Domains (1) summary

cd15008
Location:67 → 341

7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001167699.2 → NP_001161171.1 probable G-protein coupled receptor 19 isoform a

See identical proteins and their annotated locations for NP_001161171.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 3. Variants 3, 6 and 7 all encode isoform a.

Source sequence(s)

AC122193, AK132917, BB853775, BQ558507, BY275399, BY291247

Consensus CDS

CCDS51937.1

UniProtKB/Swiss-Prot

Q61121, Q810I4, Q8VDJ9

UniProtKB/TrEMBL

A0A1L1SSP1

Conserved Domains (1) summary

cd15008
Location:67 → 341

7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001167700.2 → NP_001161172.1 probable G-protein coupled receptor 19 isoform b

See identical proteins and their annotated locations for NP_001161172.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 1, 2, 4, 5, and 8-12 all encode isoform b.

Source sequence(s)

AC122193, AK132917, BY712856

Consensus CDS

CCDS20641.1

UniProtKB/TrEMBL

A0A1L1SSP1

Related

ENSMUSP00000107563.2, ENSMUST00000111932.8

Conserved Domains (1) summary

cd15008
Location:61 → 335

7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001362048.1 → NP_001348977.1 probable G-protein coupled receptor 19 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (1), as well as variants 2, 4, 5, and 8-12, encodes isoform b.

Source sequence(s)

AC122193

Consensus CDS

CCDS20641.1

UniProtKB/TrEMBL

A0A1L1SSP1

Related

ENSMUSP00000112214.3, ENSMUST00000116515.9

Conserved Domains (1) summary

cd15008
Location:61 → 335

7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001362049.1 → NP_001348978.1 probable G-protein coupled receptor 19 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (9), as well as variants 1, 2, 4, 5, 8, and 10-12, encodes isoform b.

Source sequence(s)

AC122193

Consensus CDS

CCDS20641.1

UniProtKB/TrEMBL

A0A1L1SSP1

Conserved Domains (1) summary

cd15008
Location:61 → 335

7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001362050.1 → NP_001348979.1 probable G-protein coupled receptor 19 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (10), as well as variants 1, 2, 4, 5, 8, 9, 11, and 12, encodes the same isoform (b).

Source sequence(s)

AC122193

Consensus CDS

CCDS20641.1

UniProtKB/TrEMBL

A0A1L1SSP1

Conserved Domains (1) summary

cd15008
Location:61 → 335

7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001362051.1 → NP_001348980.1 probable G-protein coupled receptor 19 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (11), as well as variants 1, 2, 4, 5, 8-10, and 12, encodes isoform b.

Source sequence(s)

AC122193

Consensus CDS

CCDS20641.1

UniProtKB/TrEMBL

A0A1L1SSP1

Conserved Domains (1) summary

cd15008
Location:61 → 335

7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001362052.1 → NP_001348981.1 probable G-protein coupled receptor 19 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (12), as well as variants 1, 2, 4, 5, and 8-11, encodes isoform b.

Source sequence(s)

AC122193

Consensus CDS

CCDS20641.1

UniProtKB/TrEMBL

A0A1L1SSP1

Conserved Domains (1) summary

cd15008
Location:61 → 335

7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_008157.3 → NP_032183.2 probable G-protein coupled receptor 19 isoform b

See identical proteins and their annotated locations for NP_032183.2

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 1, 2, 4, 5, and 8-12 all encode isoform b.

Source sequence(s)

AC122193, AK132917, BB853775, BY275399

Consensus CDS

CCDS20641.1

UniProtKB/TrEMBL

A0A1L1SSP1

Conserved Domains (1) summary

cd15008
Location:61 → 335

7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

NR_155270.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC122193, BY712856

Related

ENSMUST00000152140.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

134846055..134875157 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001167693.1: Suppressed sequence

Description

NM_001167693.1: This RefSeq was permanently suppressed because a small upstream ORF with a strong Kozak signal overlaps the expected translation start site, making it unlikely that this transcript is translated.