DDB1B damaged DNA binding protein 1B [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: DDB1B
Official Full Name: damaged DNA binding protein 1B
Primary source: TAIR:AT4G21100
Locus tag: AT4G21100
See related: Araport:AT4G21100
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: damaged DNA binding protein 1B; F7J7.40; F7J7_40
Summary: One of two closely related genes similar to a damaged DNA binding protein originally described in mammals. May form a complex with DET1 to regulate photomorphogenesis. Loss of function mutations are lethal. The DDB1b protein binds with a number of DWD-containing proteins and may form part of a CUL4-based E3 ubiquitin ligase.
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

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DDB1A and DDB1B contribute to DET1 regulation of adult plant growth.
Title: Genetic interactions of Arabidopsis thaliana damaged DNA binding protein 1B (DDB1B) with DDB1A, DET1, and COP1.
Results show that DDB1A is required for UV regulation of DDB1B and DDB2 mRNA levels while DDB1A is sufficient to increase Arabidopsis UV tolerance.
Title: Overexpression of Arabidopsis damaged DNA binding protein 1A (DDB1A) enhances UV tolerance.
Arabidopsis cullin 4 is shown to assemble with DDB1, RBX1, DET1 and DDB2 in vitro and in planta.[DDB1b]
Title: CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_118228.4

Function	Evidence Code	Pubs
enables damaged DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

NP_193842.1

damaged DNA binding protein 1B (DDB1B); CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), Cleavage/polyadenylation specificity factor, A subunit, C-terminal (InterPro:IPR004871); BEST Arabidopsis thaliana protein match is: damaged DNA binding protein 1A (TAIR:AT4G05420.1); Has 1459 Blast hits to 1199 proteins in 224 species: Archae - 0; Bacteria - 0; Metazoa - 547; Fungi - 391; Plants - 235; Viruses - 0; Other Eukaryotes - 286 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain