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    Sox15 SRY (sex determining region Y)-box 15 [ Mus musculus (house mouse) ]

    Gene ID: 20670, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sox15provided by MGI
    Official Full Name
    SRY (sex determining region Y)-box 15provided by MGI
    Primary source
    MGI:MGI:98363
    See related
    Ensembl:ENSMUSG00000041287 AllianceGenome:MGI:98363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sox16
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including positive regulation of G0 to G1 transition; positive regulation of satellite cell activation involved in skeletal muscle regeneration; and trophoblast giant cell differentiation. Acts upstream of or within several processes, including myoblast development; negative regulation of striated muscle tissue development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; gut; incisor; and integumental system. Orthologous to human SOX15 (SRY-box transcription factor 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 12.9), placenta adult (RPKM 3.2) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sox15 in Genome Data Viewer
    Location:
    11 B3; 11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69545863..69547553)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69655037..69656727)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene FMR1 autosomal homolog 2 Neighboring gene microRNA 467f Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene STARR-positive B cell enhancer ABC_E3965 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69476301-69476484 Neighboring gene microRNA 1934 Neighboring gene CD68 antigen

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within myoblast development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of striated muscle tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of G0 to G1 transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of satellite cell activation involved in skeletal muscle regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in trophoblast giant cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor SOX-15
    Names
    SRY (sex determining region Y)-box 16
    SRY-box containing gene 15
    SRY-box containing gene 16
    SRY-box transcription factor 15
    protein SOX-15
    protein SOX-16

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009235.2NP_033261.1  transcription factor SOX-15

      See identical proteins and their annotated locations for NP_033261.1

      Status: VALIDATED

      Source sequence(s)
      AK131957, BU758023
      Consensus CDS
      CCDS24902.1
      UniProtKB/Swiss-Prot
      O70204, P43267, P70418, Q62246, Q62247, Q91V00, Q91V43, Q920T1, Q9JLG2
      UniProtKB/TrEMBL
      Q5F2B2
      Related
      ENSMUSP00000048524.6, ENSMUST00000047373.6
      Conserved Domains (1) summary
      cd01388
      Location:46117
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69545863..69547553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)