Rras related RAS viral (r-ras) oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rrasprovided by MGI
Official Full Name: related RAS viral (r-ras) oncogeneprovided by MGI
Primary source: MGI:MGI:98179
See related: Ensembl:ENSMUSG00000038387 AllianceGenome:MGI:98179
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rras1
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within negative regulation of Schwann cell migration. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human RRAS (RAS related). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 109.9), bladder adult (RPKM 109.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.08 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (44665686..44671070)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45017942..45021646)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy.
Title: Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy.
R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System.
Title: R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System.
R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development.
Title: R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development.
Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling.
Title: Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling.
Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
Title: Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
although R-Ras does not influence the skin wound healing itself, the blood vessels lacking R-Ras are leaky and thus could facilitate the access of blood-derived proteins to the wound
Title: R-Ras regulates vascular permeability, but not overall healing in skin wounds.
FliI is required for the interaction of Rasgap(120) with G3BP1 to regulate R-ras activity and growth of cell extensions.
Title: The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation.
Taken together, despite having reduced number of conventional DC's in the R-Ras KO mice and low expression of CD80 on DC's, the R-Ras KO mice are capable of mounting papain-induced IgE responses comparable to that of the WT mice.
Title: R-Ras deficiency does not affect papain-induced IgE production in mice.
R-Ras is pro-tumourigenic in the mouse DMBA/TPA tumour model and important for the inflammatory response to DMBA/TPA treatment.
Title: Resistance of R-Ras knockout mice to skin tumour induction.
the data provide evidence for a role of R-Ras in the mediation of chemokine receptor-mediated signaling in migrating T cells in the high endothelial venules.
Title: R-Ras Regulates Murine T Cell Migration and Intercellular Adhesion Molecule-1 Binding.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF403987 (e-PCR)
- UniSTS:246540

NoName (e-PCR)
- UniSTS:490552

AI573426 (e-PCR)
- UniSTS:179569

Rras (e-PCR), detects polymorphism
- UniSTS:144362

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of Schwann cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in face morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in face morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in leukocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in leukocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Schwann cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasculogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-related protein R-Ras

Names: Harvey rat sarcoma oncogene, subgroup R; p23

NP_001347061.1

EC 3.6.5.2

NP_001347062.1

EC 3.6.5.2

NP_033127.1

EC 3.6.5.2

XP_036008706.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360132.2 → NP_001347061.1 ras-related protein R-Ras isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC126256

Conserved Domains (1) summary

cl21455
Location:2 → 141

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001360133.2 → NP_001347062.1 ras-related protein R-Ras isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC126256

Conserved Domains (1) summary

cl21455
Location:1 → 99

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_009101.4 → NP_033127.1 ras-related protein R-Ras isoform 1

See identical proteins and their annotated locations for NP_033127.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC126256

Consensus CDS

CCDS21226.1

UniProtKB/Swiss-Prot

P10833

UniProtKB/TrEMBL

Q3U1N3

Related

ENSMUSP00000042150.8, ENSMUST00000044111.10

Conserved Domains (1) summary

cd04145
Location:28 → 191

M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

44665686..44671070

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152813.1 → XP_036008706.1 ras-related protein R-Ras isoform X1

UniProtKB/Swiss-Prot

P10833

UniProtKB/TrEMBL

Q3U1N3

Conserved Domains (1) summary

cd04145
Location:28 → 191

M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3