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    Ngdn neuroguidin, EIF4E binding protein [ Mus musculus (house mouse) ]

    Gene ID: 68966, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ngdnprovided by MGI
    Official Full Name
    neuroguidin, EIF4E binding proteinprovided by MGI
    Primary source
    MGI:MGI:1916216
    See related
    Ensembl:ENSMUSG00000022204 AllianceGenome:MGI:1916216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ngd; neuroguidin; 1500001L15Rik
    Summary
    Predicted to be involved in several processes, including maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of protein localization to plasma membrane; and regulation of translation at postsynapse. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in several cellular components, including glutamatergic synapse; nucleolus; and perforant pathway to dendrate granule cell synapse. Is expressed in 2-cell stage embryo; 4-cell stage embryo; and cerebral cortex ventricular layer. Orthologous to human NGDN (neuroguidin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 21.1), placenta adult (RPKM 21.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ngdn in Genome Data Viewer
    Location:
    14 C3; 14 28.03 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55252911..55261595)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55015454..55024138)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 7, cardiac muscle, beta Neighboring gene microRNA 208b Neighboring gene predicted gene, 31251 Neighboring gene STARR-seq mESC enhancer starr_36751 Neighboring gene VISTA enhancer mm771 Neighboring gene VISTA enhancer mm1288 Neighboring gene STARR-positive B cell enhancer ABC_E7316 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:55633922-55634031 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:55634351-55634460 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_36756 Neighboring gene zinc finger homeobox 2 Neighboring gene zinc finger homeobox 2, opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 
    • Transgenic (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perforant pathway to dendrate granule cell synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in perforant pathway to dendrate granule cell synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    neuroguidin
    Names
    EIF4E-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026890.2NP_081166.1  neuroguidin

      See identical proteins and their annotated locations for NP_081166.1

      Status: VALIDATED

      Source sequence(s)
      AK005098, BC052790, CN715203
      Consensus CDS
      CCDS36928.1
      UniProtKB/Swiss-Prot
      Q8CIJ2, Q9DB96
      Related
      ENSMUSP00000022815.9, ENSMUST00000022815.10
      Conserved Domains (1) summary
      pfam04000
      Location:1897
      Sas10_Utp3; Sas10/Utp3/C1D family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55252911..55261595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)