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    Ppp4r2 protein phosphatase 4, regulatory subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 232314, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ppp4r2provided by MGI
    Official Full Name
    protein phosphatase 4, regulatory subunit 2provided by MGI
    Primary source
    MGI:MGI:3027896
    See related
    Ensembl:ENSMUSG00000052144 AllianceGenome:MGI:3027896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C230060M08Rik
    Summary
    Predicted to enable protein phosphatase regulator activity and protein-macromolecule adaptor activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in cytoplasm and nucleus. Part of protein phosphatase 4 complex. Is expressed in several structures, including genitourinary system; gut; immune system; liver and biliary system; and nervous system. Orthologous to human PPP4R2 (protein phosphatase 4 regulatory subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 16.8), CNS E14 (RPKM 12.1) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ppp4r2 in Genome Data Viewer
    Location:
    6 D3; 6 46.93 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (100810596..100846891)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (100833620..100869934)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16870 Neighboring gene SHQ1 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer mm9_chr6:100621045-100621346 Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene glucoside xylosyltransferase 2 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1325 Neighboring gene STARR-positive B cell enhancer ABC_E2197 Neighboring gene STARR-seq mESC enhancer starr_16873 Neighboring gene STARR-seq mESC enhancer starr_16877 Neighboring gene STARR-seq mESC enhancer starr_16880 Neighboring gene transmembrane protein 258 pseudogene Neighboring gene PDZ domain containing RING finger 3 Neighboring gene predicted gene, 26911

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein phosphatase 4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein phosphatase 4 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein phosphatase 4 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein phosphatase 4 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418205.1NP_001405134.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC155648
      UniProtKB/Swiss-Prot
      Q0VGB7, Q4G0D4, Q6P6N7, Q6PHU6, Q8BUU5
    2. NM_001418206.1NP_001405135.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC155648
      UniProtKB/Swiss-Prot
      Q0VGB7, Q4G0D4, Q6P6N7, Q6PHU6, Q8BUU5
    3. NM_001418207.1NP_001405136.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC155648
      UniProtKB/Swiss-Prot
      Q0VGB7, Q4G0D4, Q6P6N7, Q6PHU6, Q8BUU5
    4. NM_001418208.1NP_001405137.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC155648
      UniProtKB/Swiss-Prot
      Q0VGB7, Q4G0D4, Q6P6N7, Q6PHU6, Q8BUU5
    5. NM_001418209.1NP_001405138.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC155648
      UniProtKB/Swiss-Prot
      Q0VGB7, Q4G0D4, Q6P6N7, Q6PHU6, Q8BUU5
      Related
      ENSMUSP00000145102.2, ENSMUST00000203580.2
    6. NM_001418210.1NP_001405139.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC155648
    7. NM_182939.5NP_891984.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform a

      See identical proteins and their annotated locations for NP_891984.1

      Status: VALIDATED

      Source sequence(s)
      AC155648
      Consensus CDS
      CCDS20391.1
      UniProtKB/Swiss-Prot
      Q0VGB7, Q4G0D4, Q6P6N7, Q6PHU6, Q8BUU5
      UniProtKB/TrEMBL
      A0A0R4J0U2
      Related
      ENSMUSP00000066314.5, ENSMUST00000063854.7
      Conserved Domains (1) summary
      pfam09184
      Location:6258
      PPP4R2; PPP4R2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      100810596..100846891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)