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    Atg3 autophagy related 3 [ Mus musculus (house mouse) ]

    Gene ID: 67841, updated on 9-Dec-2024

    Summary

    Official Symbol
    Atg3provided by MGI
    Official Full Name
    autophagy related 3provided by MGI
    Primary source
    MGI:MGI:1915091
    See related
    Ensembl:ENSMUSG00000022663 AllianceGenome:MGI:1915091
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APG3; Apg3l; Atg3l; PC3-96; 2610016C12Rik
    Summary
    Enables Atg12 transferase activity and Atg8-family ligase activity. Involved in autophagosome assembly; mitochondrial fragmentation involved in apoptotic process; and regulation of cilium assembly. Acts upstream of or within macroautophagy and negative regulation of phagocytosis. Predicted to be part of Atg12-Atg5-Atg16 complex and cytoplasmic ubiquitin ligase complex. Predicted to be active in cytosol and phagophore assembly site. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human ATG3 (autophagy related 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 24.2), bladder adult (RPKM 17.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atg3 in Genome Data Viewer
    Location:
    16 29.45 cM; 16 B5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44979192..45008901)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45158829..45188538)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 80 Neighboring gene solute carrier family 35, member A5 Neighboring gene STARR-positive B cell enhancer ABC_E1490 Neighboring gene STARR-positive B cell enhancer ABC_E1925 Neighboring gene 40S ribosomal protein S24-like Neighboring gene STARR-seq mESC enhancer starr_40914 Neighboring gene STARR-positive B cell enhancer ABC_E8910 Neighboring gene B and T lymphocyte associated

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Atg12 transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Atg8-family conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Atg8-family conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables Atg8-family conjugating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables Atg8-family ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-like protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial fragmentation involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein modification process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Atg12-Atg5-Atg16 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Atg12-Atg5-Atg16 complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytoplasmic ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ubiquitin-like-conjugating enzyme ATG3
    Names
    autophagy-related protein 3
    NP_001343295.1
    NP_080678.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356366.1NP_001343295.1  ubiquitin-like-conjugating enzyme ATG3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129601
      Conserved Domains (3) summary
      pfam03986
      Location:248
      Autophagy_N; Autophagocytosis associated protein (Atg3), N-terminal domain
      pfam03987
      Location:117178
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
      pfam10381
      Location:199222
      Autophagy_C; Autophagocytosis associated protein C-terminal
    2. NM_026402.3NP_080678.1  ubiquitin-like-conjugating enzyme ATG3 isoform 1

      See identical proteins and their annotated locations for NP_080678.1

      Status: VALIDATED

      Source sequence(s)
      AC129601
      Consensus CDS
      CCDS28194.1
      UniProtKB/Swiss-Prot
      Q3TXJ9, Q9CPX6
      Related
      ENSMUSP00000023343.4, ENSMUST00000023343.4
      Conserved Domains (3) summary
      pfam03986
      Location:8133
      Autophagy_N; Autophagocytosis associated protein (Atg3), N-terminal domain
      pfam03987
      Location:204265
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
      pfam10381
      Location:286309
      Autophagy_C; Autophagocytosis associated protein C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      44979192..45008901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)