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    Mrto4 mRNA turnover 4, ribosome maturation factor [ Mus musculus (house mouse) ]

    Gene ID: 69902, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrto4provided by MGI
    Official Full Name
    mRNA turnover 4, ribosome maturation factorprovided by MGI
    Primary source
    MGI:MGI:1917152
    See related
    Ensembl:ENSMUSG00000028741 AllianceGenome:MGI:1917152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrt4; Mg684; 2610012O22Rik
    Summary
    Predicted to be involved in nuclear-transcribed mRNA catabolic process; rRNA processing; and ribosomal large subunit biogenesis. Predicted to be located in cytoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in genitourinary system; liver lobe; pancreas; and submandibular gland primordium. Orthologous to human MRTO4 (MRT4 homolog, ribosome maturation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 24.0), liver E14 (RPKM 24.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrto4 in Genome Data Viewer
    Location:
    4 D3; 4 70.65 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139074751..139079887, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139347440..139352576, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 66 member 1 Neighboring gene aldo-keto reductase family 7, member A5 Neighboring gene STARR-positive B cell enhancer mm9_chr4:138886553-138886854 Neighboring gene cyclin D3, pseudogene Neighboring gene ER membrane protein complex subunit 1 Neighboring gene STARR-seq mESC enhancer starr_11828 Neighboring gene STARR-seq mESC enhancer starr_11829 Neighboring gene STARR-seq mESC enhancer starr_11830 Neighboring gene ubiquitin protein ligase E3 component n-recognin 4 Neighboring gene nuclear encoded tRNA valine 1 (anticodon AAC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis. Mikula M, et al. Proteome Sci, 2015. PMID 26336360, Free PMC Article
    2. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article
    3. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    4. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mRNA turnover protein 4 homolog
    Names
    MRT4, mRNA turnover 4, homolog
    mRNA turnover 4, homolog
    muscle protein684
    ribosome assembly factor Mrto4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290810.1 → NP_001277739.1  mRNA turnover protein 4 homolog isoform 1

      See identical proteins and their annotated locations for NP_001277739.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK011387, BC096556, BY083288, BY246960
      Consensus CDS
      CCDS71505.1
      UniProtKB/Swiss-Prot
      Q99JR7, Q9D0I8
      UniProtKB/TrEMBL
      A2AMU9
      Related
      ENSMUSP00000099561.4, ENSMUST00000102503.10
      Conserved Domains (1) summary
      cd05796
      Location:21 → 183
      Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...

    2. NM_001356476.1 → NP_001343405.1  mRNA turnover protein 4 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK011387, AL807811, BC096556, BY083288, BY246960
      UniProtKB/TrEMBL
      Q9QYY3
      Conserved Domains (1) summary
      cd05796
      Location:1 → 136
      Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...

    3. NM_023536.3 → NP_076025.1  mRNA turnover protein 4 homolog isoform 2

      See identical proteins and their annotated locations for NP_076025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
      Source sequence(s)
      AK011387, BC096556, BY083288, BY246960
      Consensus CDS
      CCDS18845.1
      UniProtKB/TrEMBL
      A2AMV1
      Related
      ENSMUSP00000030513.7, ENSMUST00000030513.13
      Conserved Domains (1) summary
      cd05796
      Location:21 → 183
      Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      139074751..139079887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0I8.1 GenPept UniProtKB/Swiss-Prot:Q9D0I8

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