Lgals4 lectin, galactose binding, soluble 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lgals4provided by MGI
Official Full Name: lectin, galactose binding, soluble 4provided by MGI
Primary source: MGI:MGI:107536
See related: Ensembl:ENSMUSG00000053964 AllianceGenome:MGI:107536
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: gal-4
Summary: Enables galactoside binding activity. Acts upstream of or within antibacterial peptide biosynthetic process. Located in extracellular space. Is expressed in several structures, including germ cell of gonad; gut; heart; liver; and spleen. Orthologous to human LGALS4 (galectin 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in large intestine adult (RPKM 1251.9), colon adult (RPKM 1110.2) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 16.94 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28533559..28541128)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28833122..28841710)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhancement of Vivid-based photo-activatable Gal4 transcription factor in mammalian cells.
Title: Enhancement of Vivid-based photo-activatable Gal4 transcription factor in mammalian cells.
Extracellular Galectin 4 Drives Immune Evasion and Promotes T-cell Apoptosis in Pancreatic Cancer.
Title: Extracellular Galectin 4 Drives Immune Evasion and Promotes T-cell Apoptosis in Pancreatic Cancer.
Normal Cortical Myelination in Galectin-4-Deficient Mice.
Title: Normal Cortical Myelination in Galectin-4-Deficient Mice.
patterns of galectin-4 and galectin-6 expression in the normal and the dextran sodium sulfate (DSS)-damaged digestive
Title: Expression patterns suggest that despite considerable functional redundancy, galectin-4 and -6 play distinct roles in normal and damaged mouse digestive tract.
structure of galectin-4 and binding properties of the N-terminal domain carbohydrate-recognition domain (CRD)1 were further investigated and the crystal structure of CRD1 in complex with lactose was determined at 2.1 A resolution
Title: Structure of the mouse galectin-4 N-terminal carbohydrate-recognition domain reveals the mechanism of oligosaccharide recognition.
galectin-4 plays a unique role in the intestine and assign a novel role of this protein in controlling intestinal inflammation by a selective induction of T cell apoptosis and cell cycle restriction
Title: Galectin-4 controls intestinal inflammation by selective regulation of peripheral and mucosal T cell apoptosis and cell cycle.
X-ray analysis of the N-terminal domain of colon cancer marker Gal-4 is revealed in complex with lactose (the basic building block of known galectin-4 carbohydrate ligands).
Title: Crystallization and preliminary X-ray diffraction analysis of mouse galectin-4 N-terminal carbohydrate recognition domain in complex with lactose.
The galectin-4-mediated stimulation of CD4(+) T cells is shown to exacerbate chronic colitis and delay the recovery from acute intestinal injury
Title: Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation.
While the CRD2 domain of galectin-4 has a high specificity and affinity for A type-2 alpha-GalNAc structures, the CRD1 domain has a broader specificity in correlation to the total binding profile.
Title: Role of the carbohydrate recognition domains of mouse galectin-4 in oligosaccharide binding and epitope recognition and expression of galectin-4 and galectin-6 in mouse cells and tissues.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139632 (e-PCR)
- UniSTS:221716

RH140494 (e-PCR)
- UniSTS:221716

RH124256 (e-PCR)
- UniSTS:161078

Lgals4 (e-PCR), detects polymorphism
- UniSTS:525638

Lgals4 (e-PCR), detects polymorphism
- UniSTS:525639

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables galactoside binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within antibacterial peptide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: galectin-4

Names: lactose-binding lectin 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412662.1 → NP_001399591.1 galectin-4 isoform 2

Status: VALIDATED

Source sequence(s)

AC171210

UniProtKB/TrEMBL

Q52LA0

Related

ENSMUSP00000146429.2, ENSMUST00000208971.2
NM_010706.3 → NP_034836.1 galectin-4 isoform 1

See identical proteins and their annotated locations for NP_034836.1

Status: VALIDATED

Source sequence(s)

AC171210

Consensus CDS

CCDS21058.1

UniProtKB/Swiss-Prot

O88353, Q8K419, Q91X74

UniProtKB/TrEMBL

A5XZ78, A5XZ79, Q3UL35, Q52LA0

Related

ENSMUSP00000066461.9, ENSMUST00000066723.15

Conserved Domains (2) summary

smart00908
Location:203 → 325

Gal-bind_lectin; Galactoside-binding lectin

cd00070
Location:18 → 147

GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...