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    Epn1 epsin 1 [ Mus musculus (house mouse) ]

    Gene ID: 13854, updated on 27-Nov-2024

    Summary

    Official Symbol
    Epn1provided by MGI
    Official Full Name
    epsin 1provided by MGI
    Primary source
    MGI:MGI:1333763
    See related
    Ensembl:ENSMUSG00000035203 AllianceGenome:MGI:1333763
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ibp1
    Summary
    Predicted to enable several functions, including clathrin adaptor activity; clathrin binding activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including Notch signaling pathway; female pregnancy; and in utero embryonic development. Predicted to be located in cytosol; postsynaptic membrane; and presynaptic membrane. Predicted to be part of clathrin vesicle coat. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; endosome; and postsynapse. Is expressed in embryo. Orthologous to human EPN1 (epsin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 208.8), colon adult (RPKM 120.0) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Epn1 in Genome Data Viewer
    Location:
    7 A1; 7 2.94 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (5083207..5101178)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (5080137..5098179)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15510 Neighboring gene coiled-coil domain containing 106 Neighboring gene STARR-positive B cell enhancer ABC_E3697 Neighboring gene STARR-positive B cell enhancer ABC_E9020 Neighboring gene STARR-positive B cell enhancer ABC_E4891 Neighboring gene U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 Neighboring gene STARR-positive B cell enhancer ABC_E4892 Neighboring gene ret finger protein-like 4 Neighboring gene RAS-like, family 2, locus 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC106041

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular sequestering activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular sequestering activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic organ development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within female pregnancy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in membrane fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    epsin-1
    Names
    EPS-15-interacting protein 1
    intersectin-EH-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252454.2NP_001239383.1  epsin-1 isoform 1

      See identical proteins and their annotated locations for NP_001239383.1

      Status: VALIDATED

      Source sequence(s)
      AC162893
      Consensus CDS
      CCDS20758.1
      UniProtKB/Swiss-Prot
      O70446, Q6NX78, Q80VP1
      Related
      ENSMUSP00000043340.7, ENSMUST00000045277.7
      Conserved Domains (2) summary
      PRK07764
      Location:270437
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd16990
      Location:19142
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    2. NM_001372500.1NP_001359429.1  epsin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162893
      Consensus CDS
      CCDS90155.1
      Conserved Domains (3) summary
      PHA03247
      Location:256524
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:267393
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd16990
      Location:19142
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    3. NM_001412337.1NP_001399266.1  epsin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC162893
      UniProtKB/Swiss-Prot
      O70446, Q6NX78, Q80VP1
    4. NM_001412338.1NP_001399267.1  epsin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC162893
      UniProtKB/Swiss-Prot
      O70446, Q6NX78, Q80VP1
    5. NM_001412339.1NP_001399268.1  epsin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC162893
      UniProtKB/Swiss-Prot
      O70446, Q6NX78, Q80VP1
    6. NM_001412340.1NP_001399269.1  epsin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC162893
      UniProtKB/Swiss-Prot
      O70446, Q6NX78, Q80VP1
    7. NM_001412341.1NP_001399270.1  epsin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC162893
      UniProtKB/Swiss-Prot
      O70446, Q6NX78, Q80VP1
    8. NM_001412342.1NP_001399271.1  epsin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC162893
      UniProtKB/Swiss-Prot
      O70446, Q6NX78, Q80VP1
    9. NM_001412343.1NP_001399272.1  epsin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC162893
      UniProtKB/Swiss-Prot
      O70446, Q6NX78, Q80VP1
    10. NM_001412344.1NP_001399273.1  epsin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC162893
      UniProtKB/Swiss-Prot
      O70446, Q6NX78, Q80VP1
    11. NM_001412345.1NP_001399274.1  epsin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162893
    12. NM_001412346.1NP_001399275.1  epsin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162893
    13. NM_001412347.1NP_001399276.1  epsin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162893
    14. NM_001412348.1NP_001399277.1  epsin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162893
    15. NM_001412349.1NP_001399278.1  epsin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162893
    16. NM_001412350.1NP_001399279.1  epsin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162893
      Related
      ENSMUSP00000146638.2, ENSMUST00000208634.2
    17. NM_001412351.1NP_001399280.1  epsin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162893
    18. NM_001412352.1NP_001399281.1  epsin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162893
    19. NM_001412353.1NP_001399282.1  epsin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162893
    20. NM_001412354.1NP_001399283.1  epsin-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC162893
    21. NM_001412355.1NP_001399284.1  epsin-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC162893
    22. NM_001412356.1NP_001399285.1  epsin-1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC162893
    23. NM_001412357.1NP_001399286.1  epsin-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC162893
    24. NM_001412358.1NP_001399287.1  epsin-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC162893
    25. NM_001412359.1NP_001399288.1  epsin-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC162893
    26. NM_001412360.1NP_001399289.1  epsin-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC162893
    27. NM_001412361.1NP_001399290.1  epsin-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC162893
    28. NM_001412362.1NP_001399291.1  epsin-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC162893
    29. NM_001412363.1NP_001399292.1  epsin-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC162893
    30. NM_001412364.1NP_001399293.1  epsin-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC162893
    31. NM_001412365.1NP_001399294.1  epsin-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC162893
    32. NM_001412366.1NP_001399295.1  epsin-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC162893
    33. NM_001412367.1NP_001399296.1  epsin-1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162893
    34. NM_001412368.1NP_001399297.1  epsin-1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162893
    35. NM_001412369.1NP_001399298.1  epsin-1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162893
    36. NM_001412370.1NP_001399299.1  epsin-1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162893
    37. NM_001412371.1NP_001399300.1  epsin-1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162893
    38. NM_001412372.1NP_001399301.1  epsin-1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162893
    39. NM_001412373.1NP_001399302.1  epsin-1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162893
    40. NM_001412374.1NP_001399303.1  epsin-1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162893
    41. NM_001412375.1NP_001399304.1  epsin-1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162893
    42. NM_001412376.1NP_001399305.1  epsin-1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162893
    43. NM_001412377.1NP_001399306.1  epsin-1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162893
    44. NM_001412378.1NP_001399307.1  epsin-1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC162893
    45. NM_001412379.1NP_001399308.1  epsin-1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC162893
    46. NM_001412380.1NP_001399309.1  epsin-1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC162893
    47. NM_001412381.1NP_001399310.1  epsin-1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC162893
    48. NM_001412382.1NP_001399311.1  epsin-1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC162893
    49. NM_001412383.1NP_001399312.1  epsin-1 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC162893
    50. NM_001412384.1NP_001399313.1  epsin-1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC162893
    51. NM_001412385.1NP_001399314.1  epsin-1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC162893
    52. NM_001412386.1NP_001399315.1  epsin-1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC162893
    53. NM_001412388.1NP_001399317.1  epsin-1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC162893
    54. NM_001412389.1NP_001399318.1  epsin-1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC162893
    55. NM_001412390.1NP_001399319.1  epsin-1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC162893
    56. NM_001412391.1NP_001399320.1  epsin-1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC162893
    57. NM_001412392.1NP_001399321.1  epsin-1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC162893
    58. NM_001412393.1NP_001399322.1  epsin-1 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC162893
    59. NM_001412394.1NP_001399323.1  epsin-1 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC162893
    60. NM_001412395.1NP_001399324.1  epsin-1 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC162893
    61. NM_001412397.1NP_001399326.1  epsin-1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC162893
    62. NM_001412398.1NP_001399327.1  epsin-1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC162893
    63. NM_001412399.1NP_001399328.1  epsin-1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC162893
    64. NM_001412400.1NP_001399329.1  epsin-1 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC162893
    65. NM_001412401.1NP_001399330.1  epsin-1 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC162893
    66. NM_001412402.1NP_001399331.1  epsin-1 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC162893
    67. NM_001412403.1NP_001399332.1  epsin-1 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC162893
    68. NM_010147.5NP_034277.1  epsin-1 isoform 1

      See identical proteins and their annotated locations for NP_034277.1

      Status: VALIDATED

      Source sequence(s)
      AC162893
      Consensus CDS
      CCDS20758.1
      UniProtKB/Swiss-Prot
      O70446, Q6NX78, Q80VP1
      Related
      ENSMUSP00000096445.4, ENSMUST00000098845.10
      Conserved Domains (2) summary
      PRK07764
      Location:270437
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd16990
      Location:19142
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      5083207..5101178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539531.4XP_006539594.2  epsin-1 isoform X1

      See identical proteins and their annotated locations for XP_006539594.2

      UniProtKB/Swiss-Prot
      Q80VP1
      Conserved Domains (3) summary
      PHA03247
      Location:256524
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:267393
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd16990
      Location:19142
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    2. XM_030242119.1XP_030097979.1  epsin-1 isoform X11

      Conserved Domains (2) summary
      PHA03247
      Location:63333
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:74200
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
    3. XM_036152660.1XP_036008553.1  epsin-1 isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:256524
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:267393
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd16990
      Location:19142
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    4. XM_036152661.1XP_036008554.1  epsin-1 isoform X6

      UniProtKB/Swiss-Prot
      O70446, Q6NX78, Q80VP1
      Conserved Domains (2) summary
      PRK07764
      Location:270437
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd16990
      Location:19142
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family