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    Akap3 A kinase anchor protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 11642, updated on 9-Dec-2024

    Summary

    Official Symbol
    Akap3provided by MGI
    Official Full Name
    A kinase anchor protein 3provided by MGI
    Primary source
    MGI:MGI:1341149
    See related
    Ensembl:ENSMUSG00000030344 AllianceGenome:MGI:1341149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prka3
    Summary
    Enables protein kinase A binding activity. Involved in establishment of protein localization and flagellated sperm motility. Acts upstream of or within blastocyst hatching; cell surface receptor protein serine/threonine kinase signaling pathway; and protein localization. Located in acrosomal vesicle and sperm principal piece. Is active in sperm fibrous sheath. Is expressed in early conceptus; secondary oocyte; and spermatocyte. Human ortholog(s) of this gene implicated in spermatogenic failure 82. Orthologous to human AKAP3 (A-kinase anchoring protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 181.3) See more
    Orthologs
    NEW
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    Genomic context

    See Akap3 in Genome Data Viewer
    Location:
    6 F3; 6 61.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126830061..126851271)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126853098..126874308)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8 pseudogene Neighboring gene RIKEN cDNA 1700018A23 gene Neighboring gene NADH:ubiquinone oxidoreductase subunit A9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:126799059-126799305 Neighboring gene dual-specificity tyrosine phosphorylation regulated kinase 4 Neighboring gene RAD51 associated protein 1 Neighboring gene metaxin 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase A binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in sperm fibrous sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm fibrous sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm midpiece IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sperm principal piece IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    A-kinase anchor protein 3
    Names
    A kinase (PRKA) anchor protein 3
    A-kinase anchor protein 110 kDa
    AKAP 110
    AKAP-3
    Protein kinase A-anchoring protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009650.2NP_033780.2  A-kinase anchor protein 3

      See identical proteins and their annotated locations for NP_033780.2

      Status: VALIDATED

      Source sequence(s)
      AF093406, BC100458, CN837067
      Consensus CDS
      CCDS20558.1
      UniProtKB/Swiss-Prot
      O88987, Q497M9
      Related
      ENSMUSP00000093091.6, ENSMUST00000095440.9
      Conserved Domains (1) summary
      smart00807
      Location:5864
      AKAP_110; A-kinase anchor protein 110 kDa

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      126830061..126851271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)