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    Procr protein C receptor, endothelial [ Mus musculus (house mouse) ]

    Gene ID: 19124, updated on 9-Dec-2024

    Summary

    Official Symbol
    Procrprovided by MGI
    Official Full Name
    protein C receptor, endothelialprovided by MGI
    Primary source
    MGI:MGI:104596
    See related
    Ensembl:ENSMUSG00000027611 AllianceGenome:MGI:104596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccca; Epcr; Ccd41
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in negative regulation of coagulation. Located in centrosome. Is expressed in several structures, including cardiovascular system; extraembryonic component; liver; placenta; and vasculature of uterus. Orthologous to human PROCR (protein C receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 44.4), bladder adult (RPKM 5.1) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Procr in Genome Data Viewer
    Location:
    2 H1; 2 77.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155592159..155597391)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155751125..155755478)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein Neighboring gene predicted gene, 22334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:155505379-155505532 Neighboring gene ER degradation enhancer, mannosidase alpha-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E10157 Neighboring gene STARR-seq mESC enhancer starr_06149 Neighboring gene matrix metallopeptidase 24 Neighboring gene predicted gene, 46772 Neighboring gene STARR-positive B cell enhancer ABC_E4512 Neighboring gene matrix metallopeptidase 24 opposite strand transcript 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8) 
    • Gene trapped (1) 
    • Targeted (11)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of coagulation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    endothelial protein C receptor
    Names
    APC receptor
    CD antigen CD201
    activated protein C receptor
    centrocyclin
    centrosomal protein CCD41
    endothelial cell protein C receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420719.1NP_001407648.1  endothelial protein C receptor isoform b

      Status: VALIDATED

      Source sequence(s)
      AL929233
    2. NM_001420720.1NP_001407649.1  endothelial protein C receptor isoform b

      Status: VALIDATED

      Source sequence(s)
      AL929233
    3. NM_011171.3NP_035301.2  endothelial protein C receptor isoform a precursor

      See identical proteins and their annotated locations for NP_035301.2

      Status: VALIDATED

      Source sequence(s)
      AL929233
      Consensus CDS
      CCDS16954.1
      UniProtKB/Swiss-Prot
      Q4FK76, Q64695, Q9WV33
      Related
      ENSMUSP00000029140.6, ENSMUST00000029140.12
      Conserved Domains (1) summary
      cl08246
      Location:21194
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155592159..155597391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498955.3XP_006499018.1  endothelial protein C receptor isoform X1

      See identical proteins and their annotated locations for XP_006499018.1

      UniProtKB/TrEMBL
      Q8K357
      Conserved Domains (1) summary
      cl08246
      Location:20194
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2