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    Fermt2 fermitin family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 218952, updated on 3-Dec-2024

    Summary

    Official Symbol
    Fermt2provided by MGI
    Official Full Name
    fermitin family member 2provided by MGI
    Primary source
    MGI:MGI:2385001
    See related
    Ensembl:ENSMUSG00000037712 AllianceGenome:MGI:2385001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mig2; Plekhc1; Kindlin-2
    Summary
    Enables actin filament binding activity. Involved in several processes, including focal adhesion assembly; integrin activation; and positive regulation of osteoblast differentiation. Located in stress fiber. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and musculature. Orthologous to human FERMT2 (FERM domain containing kindlin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 89.4), placenta adult (RPKM 48.8) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fermt2 in Genome Data Viewer
    Location:
    14 C1; 14 22.97 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (45696252..45767767, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (45458792..45530310, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36535 Neighboring gene predicted gene, 41143 Neighboring gene STARR-seq mESC enhancer starr_36537 Neighboring gene predicted gene, 34250 Neighboring gene STARR-seq mESC enhancer starr_36545 Neighboring gene STARR-seq mESC enhancer starr_36547 Neighboring gene RIKEN cDNA 4930527F14 gene Neighboring gene predicted gene, 41144 Neighboring gene predicted pseudogene 5206

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC36305

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables type I transforming growth factor beta receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables type I transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adherens junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adherens junction maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in integrin activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in limb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of integrin activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of integrin activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mesenchymal stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mesenchymal stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myosin light chain kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of wound healing, spreading of epidermal cells IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein localization to cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in I band IEA
    Inferred from Electronic Annotation
    more info
     
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fermitin family homolog 2
    Names
    mitogen inducible 2
    pleckstrin homology domain containing, family C (with FERM domain) member 1
    pleckstrin homology domain-containing family C member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360525.2NP_001347454.1  fermitin family homolog 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102445, CT025535, LXEJ02000532
      UniProtKB/TrEMBL
      Q3UMA4
      Conserved Domains (4) summary
      cd01237
      Location:384508
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      pfam00373
      Location:520584
      FERM_M; FERM central domain
      cl09511
      Location:252312
      FERM_B-lobe; FERM domain B-lobe
      cl17171
      Location:578669
      PH-like; Pleckstrin homology-like domain
    2. NM_001360526.2NP_001347455.1  fermitin family homolog 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102445, CT025535, LXEJ02000532
      UniProtKB/TrEMBL
      Q3UMA4
      Conserved Domains (4) summary
      cd01237
      Location:373497
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      pfam00373
      Location:509580
      FERM_M; FERM central domain
      cl09511
      Location:241301
      FERM_B-lobe; FERM domain B-lobe
      cl17171
      Location:574665
      PH-like; Pleckstrin homology-like domain
    3. NM_001425724.1NP_001412653.1  fermitin family homolog 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC102445, CT025535, LXEJ02000532
      UniProtKB/TrEMBL
      Q3UMA4
    4. NM_001425725.1NP_001412654.1  fermitin family homolog 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC102445, CT025535, LXEJ02000532
      UniProtKB/TrEMBL
      Q3UMA4
    5. NM_001425726.1NP_001412655.1  fermitin family homolog 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC102445, CT025535, LXEJ02000532
      UniProtKB/TrEMBL
      Q3UMA4
    6. NM_001425728.1NP_001412657.1  fermitin family homolog 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC102445, CT025535, LXEJ02000532
      UniProtKB/TrEMBL
      Q3UMA4
    7. NM_001425729.1NP_001412658.1  fermitin family homolog 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC102445, CT025535, LXEJ02000532
      UniProtKB/TrEMBL
      Q3UMA4
    8. NM_146054.4NP_666166.2  fermitin family homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_666166.2

      Status: VALIDATED

      Source sequence(s)
      AC102445, CT025535, LXEJ02000532
      Consensus CDS
      CCDS26977.1
      UniProtKB/Swiss-Prot
      Q8C542, Q8CIB5, Q8K035
      UniProtKB/TrEMBL
      Q3TLE2, Q3UMA4
      Related
      ENSMUSP00000044554.7, ENSMUST00000045905.15
      Conserved Domains (4) summary
      cd01237
      Location:373497
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      pfam00169
      Location:381476
      PH; PH domain
      pfam00373
      Location:509573
      FERM_M; FERM central domain
      cl17171
      Location:567658
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      45696252..45767767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158558.1XP_036014451.1  fermitin family homolog 2 isoform X3

      UniProtKB/TrEMBL
      Q3UMA4
      Conserved Domains (5) summary
      cd01237
      Location:373497
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd17181
      Location:1796
      FERM_F0_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in kindlin-2 (KIND2)
      cd17184
      Location:97277
      FERM_F1_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-2 (KIND2)
      pfam00373
      Location:515588
      FERM_M; FERM central domain
      cl17171
      Location:582673
      PH-like; Pleckstrin homology-like domain
    2. XM_036158557.1XP_036014450.1  fermitin family homolog 2 isoform X1

      UniProtKB/TrEMBL
      Q3UMA4
      Conserved Domains (5) summary
      cd01237
      Location:384508
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd17181
      Location:1796
      FERM_F0_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in kindlin-2 (KIND2)
      cd17184
      Location:97288
      FERM_F1_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-2 (KIND2)
      pfam00373
      Location:526599
      FERM_M; FERM central domain
      cl17171
      Location:593684
      PH-like; Pleckstrin homology-like domain