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    Fuca2 fucosidase, alpha-L- 2, plasma [ Mus musculus (house mouse) ]

    Gene ID: 66848, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fuca2provided by MGI
    Official Full Name
    fucosidase, alpha-L- 2, plasmaprovided by MGI
    Primary source
    MGI:MGI:1914098
    See related
    Ensembl:ENSMUSG00000019810 AllianceGenome:MGI:1914098
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610025O11Rik; 5530401P20Rik
    Summary
    Predicted to enable alpha-L-fucosidase activity. Predicted to be involved in several processes, including fucose metabolic process; glycoside catabolic process; and regulation of entry of bacterium into host cell. Predicted to be located in extracellular space. Predicted to be active in lysosome. Is expressed in nervous system and respiratory system. Orthologous to human FUCA2 (alpha-L-fucosidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 23.4), heart adult (RPKM 17.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fuca2 in Genome Data Viewer
    Location:
    10 A2; 10 4.86 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (13376314..13394779)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (13500570..13519035)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25812 Neighboring gene LTV1 ribosome biogenesis factor Neighboring gene phosphatase and actin regulator 2 Neighboring gene predicted gene, 46211 Neighboring gene STARR-seq mESC enhancer starr_25813 Neighboring gene STARR-seq mESC enhancer starr_25814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13220839-13220948 Neighboring gene STARR-seq mESC enhancer starr_25815 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13272745-13273072 Neighboring gene peroxisomal biogenesis factor 3 Neighboring gene adenosine deaminase, tRNA-specific 2 Neighboring gene RIKEN cDNA A730010A20 gene Neighboring gene STARR-seq mESC enhancer starr_25816 Neighboring gene androgen-induced 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Roles of mouse sperm-associated alpha-L-fucosidases in fertilization. Phopin K, et al. Mol Reprod Dev, 2013 Apr. PMID 23426913
    2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-L-fucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-L-fucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-L-fucosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoside catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycoside catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of entry of bacterium into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of entry of bacterium into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    plasma alpha-L-fucosidase
    Names
    alpha-L-fucoside fucohydrolase 2
    NP_001317127.1
    NP_080075.2
    XP_006512890.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330198.2 → NP_001317127.1  plasma alpha-L-fucosidase isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC153979
      Consensus CDS
      CCDS23701.1
      UniProtKB/Swiss-Prot
      Q8VEM3, Q99KR8, Q9D7Z8, Q9DCL7
      UniProtKB/TrEMBL
      Q505Q3
      Related
      ENSMUSP00000055519.6, ENSMUST00000060212.13
      Conserved Domains (2) summary
      smart00812
      Location:24 → 407
      Alpha_L_fucos; Alpha-L-fucosidase
      pfam16757
      Location:370 → 455
      Fucosidase_C; Alpha-L-fucosidase C-terminal domain

    2. NM_001429394.1 → NP_001416323.1  plasma alpha-L-fucosidase isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC153979
      UniProtKB/Swiss-Prot
      Q8VEM3, Q99KR8, Q9D7Z8, Q9DCL7
      UniProtKB/TrEMBL
      Q505Q3

    3. NM_001429395.1 → NP_001416324.1  plasma alpha-L-fucosidase isoform b

      Status: VALIDATED

      Source sequence(s)
      AC153979

    4. NM_001429396.1 → NP_001416325.1  plasma alpha-L-fucosidase isoform b

      Status: VALIDATED

      Source sequence(s)
      AC153979

    5. NM_001429397.1 → NP_001416326.1  plasma alpha-L-fucosidase isoform c

      Status: VALIDATED

      Source sequence(s)
      AC153979

    6. NM_025799.6 → NP_080075.2  plasma alpha-L-fucosidase isoform a precursor

      See identical proteins and their annotated locations for NP_080075.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC153979
      Consensus CDS
      CCDS23701.1
      UniProtKB/Swiss-Prot
      Q8VEM3, Q99KR8, Q9D7Z8, Q9DCL7
      UniProtKB/TrEMBL
      Q505Q3
      Related
      ENSMUSP00000113499.3, ENSMUST00000121465.3
      Conserved Domains (2) summary
      smart00812
      Location:24 → 407
      Alpha_L_fucos; Alpha-L-fucosidase
      pfam16757
      Location:370 → 455
      Fucosidase_C; Alpha-L-fucosidase C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      13376314..13394779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512827.4 → XP_006512890.1  plasma alpha-L-fucosidase isoform X1

      Conserved Domains (2) summary
      smart00812
      Location:24 → 407
      Alpha_L_fucos; Alpha-L-fucosidase
      pfam16757
      Location:370 → 455
      Fucosidase_C; Alpha-L-fucosidase C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KR8.1 GenPept UniProtKB/Swiss-Prot:Q99KR8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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