LUH LEUNIG-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: LUH
Official Full Name: LEUNIG-like protein
Primary source: TAIR:AT2G32700
Locus tag: AT2G32700
See related: Araport:AT2G32700
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F24L7.16; F24L7_16; LEUNIG_homolog; MUCILAGE-MODIFIED 1; MUM1
Summary: Encodes a WD40 repeat and LUFS domain containing protein that is similar to LUG. Interacts physically with SEUSS and likely functions as part of a repressor complex that represses AG. Involved in cell wall modifications necessary for mucilage extrusion.
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Genomic context

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See LUH in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 19

Sequence:: Chromosome: 2; NC_003071.7 (13866721..13872246)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that LEUNIG_HOMOLOG (LUH) functions with PHYTOCHROME-INTERACTING FACTOR1 (PIF1) as a transcriptional coregulator to inhibit seed germination.
Title: The Transcriptional Coregulator LEUNIG_HOMOLOG Inhibits Light-Dependent Seed Germination in Arabidopsis.
LUH is allelic to MUM1, and MUM2 is a likely target of LUH regulation. The transcriptional corepressor LEUNIG (LUG) is functionally interchangeable with LUH, raising the possibility that LUH functions as a repressor during seed coat maturation.
Title: The transcriptional regulator LEUNIG_HOMOLOG regulates mucilage release from the Arabidopsis testa.
that SLK1, SLK2 and LUH form a co-repressor complex.
Title: Involvement of co-repressor LUH and the adapter proteins SLK1 and SLK2 in the regulation of abiotic stress response genes in Arabidopsis.
LUH/MUM1 expression appears to be independent of other transcription factors known to regulate aspects of seed coat mucilage biology.
Title: The Arabidopsis transcription factor LUH/MUM1 is required for extrusion of seed coat mucilage.
luh-1 mutant seeds exhibit mucilage extrusion defects, but do not exhibit significant changes in seed coat morphology or integument cell differentiation.
Title: LEUNIG_HOMOLOG and LEUNIG regulate seed mucilage extrusion in Arabidopsis.
YABs interact with LUG and LUH. Together these proteins maintain leaf polarity and meristem activity in Arabidopsis.
Title: YABBYs and the transcriptional corepressors LEUNIG and LEUNIG_HOMOLOG maintain leaf polarity and meristem activity in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001036389.4

Supported by ESTs:

NM_001202730.1

Supported by ESTs:

NM_128829.4

Supported by ESTs:

NM_179861.3

Supported by ESTs:

NM_179862.2

Supported by ESTs:

NM_179863.3

Supported by ESTs:

NM_179864.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to external biotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within flower development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in galacturonan metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meristem maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mucilage biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mucilage extrusion from seed coat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mucilage metabolic process involved in seed coat development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mucilage pectin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type cell wall modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plant-type cell wall modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarity specification of adaxial/abaxial axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell wall pectin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of leaf development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of shoot apical meristem development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to aluminum ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to auxin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cycloheximide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fungus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nematode	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to silver ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to wounding	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: LEUNIG-like protein

NP_001031466.2

LEUNIG_homolog (LUH); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: flower development, negative regulation of transcription, embryo development; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), LisH dimerisation motif, subgroup (InterPro:IPR013720), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: LisH dimerisation motif;WD40/YVTN repeat-like-containing domain (TAIR:AT4G32551.1); Has 67484 Blast hits to 31766 proteins in 819 species: Archae - 68; Bacteria - 8700; Metazoa - 26198; Fungi - 15367; Plants - 8354; Viruses - 0; Other Eukaryotes - 8797 (source: NCBI BLink).

NP_001189659.1

LEUNIG_homolog (LUH); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: flower development, negative regulation of transcription, embryo development; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: LisH dimerisation motif, subgroup (InterPro:IPR013720), WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: LisH dimerisation motif;WD40/YVTN repeat-like-containing domain (TAIR:AT4G32551.1).

NP_565749.1

LEUNIG_homolog (LUH); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), LisH dimerisation motif, subgroup (InterPro:IPR013720), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: LisH dimerisation motif;WD40/YVTN repeat-like-containing domain (TAIR:AT4G32551.1); Has 67720 Blast hits to 31790 proteins in 821 species: Archae - 72; Bacteria - 8702; Metazoa - 26412; Fungi - 15362; Plants - 8347; Viruses - 0; Other Eukaryotes - 8825 (source: NCBI BLink).

NP_850192.1

LEUNIG_homolog (LUH); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), LisH dimerisation motif, subgroup (InterPro:IPR013720), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: LisH dimerisation motif;WD40/YVTN repeat-like-containing domain (TAIR:AT4G32551.1); Has 67720 Blast hits to 31790 proteins in 821 species: Archae - 72; Bacteria - 8702; Metazoa - 26412; Fungi - 15362; Plants - 8347; Viruses - 0; Other Eukaryotes - 8825 (source: NCBI BLink).

NP_850193.1

LEUNIG_homolog (LUH); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), LisH dimerisation motif, subgroup (InterPro:IPR013720), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: LisH dimerisation motif;WD40/YVTN repeat-like-containing domain (TAIR:AT4G32551.1); Has 67755 Blast hits to 31813 proteins in 822 species: Archae - 72; Bacteria - 8707; Metazoa - 26414; Fungi - 15388; Plants - 8349; Viruses - 0; Other Eukaryotes - 8825 (source: NCBI BLink).

NP_850194.1

LEUNIG_homolog (LUH); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), LisH dimerisation motif, subgroup (InterPro:IPR013720), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: LisH dimerisation motif;WD40/YVTN repeat-like-containing domain (TAIR:AT4G32551.1); Has 67720 Blast hits to 31790 proteins in 821 species: Archae - 72; Bacteria - 8702; Metazoa - 26412; Fungi - 15362; Plants - 8347; Viruses - 0; Other Eukaryotes - 8825 (source: NCBI BLink).

NP_850195.2

LEUNIG_homolog (LUH); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), LisH dimerisation motif, subgroup (InterPro:IPR013720), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: LisH dimerisation motif;WD40/YVTN repeat-like-containing domain (TAIR:AT4G32551.1); Has 67720 Blast hits to 31790 proteins in 821 species: Archae - 72; Bacteria - 8702; Metazoa - 26412; Fungi - 15362; Plants - 8347; Viruses - 0; Other Eukaryotes - 8825 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

13866721..13872246

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_179863.3 → NP_850194.1 LEUNIG-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850194.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4ITU4, F4ITV0, O48847, Q0WWP4, Q3EBQ0

UniProtKB/TrEMBL

A0A178VQH2, A0A5S9X3A0, A0A654EZN8

Conserved Domains (4) summary

cd00200
Location:502 → 787

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:515 → 550

7WD40; WD40 repeat [structural motif]

pfam09606
Location:103 → 440

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam08513
Location:11 → 35

LisH
NM_128829.4 → NP_565749.1 LEUNIG-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565749.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4ITU4, F4ITV0, O48847, Q0WWP4, Q3EBQ0

UniProtKB/TrEMBL

A0A178VQH2, A0A5S9X3A0, A0A654EZN8

Conserved Domains (4) summary

cd00200
Location:502 → 787

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:515 → 550

7WD40; WD40 repeat [structural motif]

pfam09606
Location:103 → 440

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam08513
Location:11 → 35

LisH
NM_001036389.4 → NP_001031466.2 LEUNIG-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031466.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9X3A0, A0A654EZN8

Conserved Domains (4) summary

cd00200
Location:500 → 785

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:513 → 548

7WD40; WD40 repeat [structural motif]

pfam09606
Location:103 → 440

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam08513
Location:11 → 35

LisH
NM_001202730.1 → NP_001189659.1 LEUNIG-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189659.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9X3A0, A0A654EZN8

Conserved Domains (4) summary

COG2319
Location:521 → 806

WD40; WD40 repeat [General function prediction only]

cd00200
Location:521 → 806

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08513
Location:10 → 36

LisH; LisH

sd00039
Location:534 → 569

7WD40; WD40 repeat [structural motif]
NM_179862.2 → NP_850193.1 LEUNIG-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850193.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4ITU4, F4ITV0, O48847, Q0WWP4, Q3EBQ0

UniProtKB/TrEMBL

A0A178VQH2, A0A5S9X3A0, A0A654EZN8

Conserved Domains (4) summary

cd00200
Location:502 → 787

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:515 → 550

7WD40; WD40 repeat [structural motif]

pfam09606
Location:103 → 440

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam08513
Location:11 → 35

LisH
NM_179861.3 → NP_850192.1 LEUNIG-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850192.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4ITU4, F4ITV0, O48847, Q0WWP4, Q3EBQ0

UniProtKB/TrEMBL

A0A178VQH2, A0A5S9X3A0, A0A654EZN8

Conserved Domains (4) summary

cd00200
Location:502 → 787

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:515 → 550

7WD40; WD40 repeat [structural motif]

pfam09606
Location:103 → 440

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam08513
Location:11 → 35

LisH
NM_179864.3 → NP_850195.2 LEUNIG-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850195.2

Status: REVIEWED

UniProtKB/Swiss-Prot

F4ITU4, F4ITV0, O48847, Q0WWP4, Q3EBQ0

UniProtKB/TrEMBL

A0A178VQH2, A0A5S9X3A0, A0A654EZN8

Conserved Domains (4) summary

cd00200
Location:502 → 787

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:515 → 550

7WD40; WD40 repeat [structural motif]

pfam09606
Location:103 → 440

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam08513
Location:11 → 35

LisH