UTR1 UDP-galactose transporter 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: UTR1
Official Full Name: UDP-galactose transporter 1
Primary source: TAIR:AT2G02810
Locus tag: AT2G02810
See related: Araport:AT2G02810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATUTR1; T20F6.5; T20F6_5; UDP-galactose transporter 1; UDP-GALACTOSE TRANSPORTER 1
Summary: Encodes a multitransmembrane hydrophobic protein that functions as transporter of UDP-galactose and UDP-glucose into the Golgi. Localized in the ER. Involved in the unfolded protein response, a mechanism that controls proper protein folding in the ER.
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Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Biochemical analysis in both AtUTr1 and AtUTr3 mutants indicates that uptake of UDP-glucose into the endoplasmic reticulum is mostly driven by these two transporters.
Title: The nucleotide sugar transporters AtUTr1 and AtUTr3 are required for the incorporation of UDP-glucose into the endoplasmic reticulum, are essential for pollen development and are needed for embryo sac progress in Arabidopsis thaliana.
it is proposed that in A. thaliana, AtUTr1 is the UDP-glucose transporter involved in quality control in the endoplasmic reticulum
Title: AtUTr1, a UDP-glucose/UDP-galactose transporter from Arabidopsis thaliana, is located in the endoplasmic reticulum and up-regulated by the unfolded protein response.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_126336.3

Function	Evidence Code	Pubs
enables UDP-galactose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in embryo sac development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleotide-sugar transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in pollen development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

NP_565290.1

UDP-galactose transporter 1 (UTR1); CONTAINS InterPro DOMAIN/s: UAA transporter (InterPro:IPR013657); BEST Arabidopsis thaliana protein match is: UDP-galactose transporter 3 (TAIR:AT1G14360.1); Has 1052 Blast hits to 1046 proteins in 233 species: Archae - 0; Bacteria - 0; Metazoa - 503; Fungi - 150; Plants - 232; Viruses - 0; Other Eukaryotes - 167 (source: NCBI BLink).