PHB Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: PHB
Official Full Name: Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein
Primary source: TAIR:AT2G34710
Locus tag: AT2G34710
See related: Araport:AT2G34710
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA HOMEOBOX PROTEIN 14; ATHB-14; ATHB14; PHABULOSA; PHABULOSA 1D; PHB-1D; T29F13.8; T29F13_8
Summary: Dominant PHB mutations cause transformation of abaxial leaf fates into adaxial leaf fates. Encodes a member of HD-Zip family which contains homeodomain-leucine zipper domains and domain similar to a mammalian sterol binding domain. Has overlapping functions with PHAVOLUTA, REVOLUTA and CORONA.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See PHB in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 17

Sequence:: Chromosome: 2; NC_003071.7 (14639323..14644355, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A PHABULOSA-Controlled Genetic Pathway Regulates Ground Tissue Patterning in the Arabidopsis Root.
Title: A PHABULOSA-Controlled Genetic Pathway Regulates Ground Tissue Patterning in the Arabidopsis Root.
MicroRNA166 Monitors SPOROCYTELESS/NOZZLE for Building of the Anther Internal Boundary.
Title: MicroRNA166 Monitors SPOROCYTELESS/NOZZLE for Building of the Anther Internal Boundary.
In Planta Single-Molecule Pull-Down Reveals Tetrameric Stoichiometry of HD-ZIPIII:LITTLE ZIPPER Complexes.
Title: In Planta Single-Molecule Pull-Down Reveals Tetrameric Stoichiometry of HD-ZIPIII:LITTLE ZIPPER Complexes.
PHABULOSA, directly binds the promoter of both MONOPTEROS (MP)/AUXIN RESPONSE FACTOR5, a key factor in vascular formation.
Title: PHABULOSA Mediates an Auxin Signaling Loop to Regulate Vascular Patterning in Arabidopsis.
The branching ovules of the mutant resemble those of some fossil gymnosperms, implicating BEL1 and HD-ZIPIII genes as players in the evolution of the unbranched ovule form in extant angiosperms.
Title: CORONA, PHABULOSA and PHAVOLUTA collaborate with BELL1 to confine WUSCHEL expression to the nucellus in Arabidopsis ovules.
stem cell specification pathway is normally repressed by the activity of the HD-zip III transcription factors PHABULOSA (PHB), PHAVOLUTA (PHV) and CORONA (CNA).
Title: A WUSCHEL-Independent Stem Cell Specification Pathway Is Repressed by PHB, PHV and CNA in Arabidopsis.
our study suggests that PHB can dynamically regulate TA cell activities in a QC-independent manner, and that the SHR-PHB pathway enables a robust root growth system by coordinating the stem cell niche and TA domain.
Title: PHABULOSA controls the quiescent center-independent root meristem activities in Arabidopsis thaliana.
findings show that the HD-ZIPIII transcription factor PHABULOSA directly activates the cytokinin biosynthesis gene ISOPENTENYL TRANSFERASE 7, thus promoting cell differentiation and regulating root length
Title: A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis.
Pairing to the 5' portion of the small silencing RNA of PHAVOLUTA appears crucial regardless of the mode of post-transcriptional repression
Title: MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region.
Class III HD-Zip genes required for root development [PHABULOSA (PHB)]
Title: Roles for Class III HD-Zip and KANADI genes in Arabidopsis root development.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_129025.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaxial/abaxial pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of bilateral symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within integument development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within meristem initiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within polarity specification of adaxial/abaxial axis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within primary shoot apical meristem specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

Go to the top of the page Help

Preferred Names: Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein

NP_181018.1

PHABULOSA (PHB); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), MEKHLA (InterPro:IPR013978), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein (TAIR:AT1G30490.1); Has 3393 Blast hits to 3288 proteins in 275 species: Archae - 0; Bacteria - 20; Metazoa - 905; Fungi - 114; Plants - 2320; Viruses - 0; Other Eukaryotes - 34 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

14639323..14644355 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129025.4 → NP_181018.1 Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181018.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O04291

UniProtKB/TrEMBL

A0A178VWD3, A0A5S9X3X6, A0A654EYV0

Conserved Domains (4) summary

cd08875
Location:168 → 384

START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins

cd14686
Location:77 → 116

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

pfam00046
Location:25 → 83

Homeobox; Homeobox domain

pfam08670
Location:707 → 851

MEKHLA; MEKHLA domain