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    ACLA-3 ATP-citrate lyase A-3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837466, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACLA-3
    Official Full Name
    ATP-citrate lyase A-3
    Primary source
    TAIR:AT1G09430
    Locus tag
    AT1G09430
    See related
    Araport:AT1G09430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATP-citrate lyase A-3; F14J9.9; F14J9_9
    Summary
    Encodes subunit A of the heteromeric enzyme ATP citrate lyase (ACL). In animals, ACL is encoded by a single gene; ACL in Arabidopsis is composed of two polypeptides, ACLA (encoded by 3 genes) and ACLB (encoded by 2 genes). The holoenzyme has an A(4)B(4)stoichiometry. Expression of both ACLA and ACLB but not of either of the subunits alone results in ACL activity.
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    Genomic context

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    See ACLA-3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (3041996..3045541)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene NIM1-interacting 3 Neighboring gene ncRNA Neighboring gene glucose-6-phosphate dehydrogenase 4 Neighboring gene Protein kinase superfamily protein Neighboring gene Protein kinase superfamily protein Neighboring gene Carbohydrate-binding X8 domain superfamily protein Neighboring gene myosin heavy chain, cardiac protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a heteromeric ATP-citrate lyase that generates cytosolic acetyl-coenzyme A in Arabidopsis. Fatland BL, et al. Plant Physiol, 2002 Oct. PMID 12376641, Free PMC Article
    2. Protein and metabolite composition of Arabidopsis stress granules. Kosmacz M, et al. New Phytol, 2019 May. PMID 30664249
    3. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_100814.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP citrate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acetyl-CoA biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATP-dependent citrate lyase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in extracellular region HDA PubMed 

    General protein information

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    Preferred Names
    ATP-citrate lyase A-3
    NP_172414.1
    • ATP-citrate lyase A-3 (ACLA-3); CONTAINS InterPro DOMAIN/s: ATP-grasp fold, subdomain 2 (InterPro:IPR013816), ATP-grasp fold, succinyl-CoA synthetase-type (InterPro:IPR013650), Succinyl-CoA synthetase-like (InterPro:IPR016102); BEST Arabidopsis thaliana protein match is: ATP-citrate lyase A-1 (TAIR:AT1G10670.4); Has 5303 Blast hits to 5302 proteins in 1635 species: Archae - 133; Bacteria - 3235; Metazoa - 230; Fungi - 139; Plants - 96; Viruses - 0; Other Eukaryotes - 1470 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3041996..3045541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100814.4 → NP_172414.1  ATP-citrate lyase A-3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80526
      UniProtKB/TrEMBL
      A0A178WAZ4, A0A654EA62, A0A7G2DU60
      Conserved Domains (1) summary
      PLN02235
      Location:1 → 423
      PLN02235; ATP citrate (pro-S)-lyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80526.1

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