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    UVH6 RAD3-like DNA-binding helicase protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839557, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UVH6
    Official Full Name
    RAD3-like DNA-binding helicase protein
    Primary source
    TAIR:AT1G03190
    Locus tag
    AT1G03190
    See related
    Araport:AT1G03190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA XERODERMA PIGMENTOSUM GROUP D; ATXPD; ULTRAVIOLET HYPERSENSITIVE 6
    Summary
    UV damage and heat induce a common stress response in plants that leads to tissue death and reduced chloroplast function. The UVH6 product is suggested to be a negative regulator of this response.
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    Genomic context

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    See UVH6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (775527..780062)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene FANTASTIC four-like protein (DUF3049) Neighboring gene non-structural protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Phenazine biosynthesis PhzC/PhzF protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome stability in the uvh6 mutant of Arabidopsis thaliana. Bilichak A, et al. Plant Cell Rep, 2014 Jun. PMID 24553752
    2. Arabidopsis UVH6, a homolog of human XPD and yeast RAD3 DNA repair genes, functions in DNA repair and is essential for plant growth. Liu Z, et al. Plant Physiol, 2003 Jul. PMID 12857822, Free PMC Article
    3. Genetic interactions between Arabidopsis DET1 and UVH6 during development and abiotic stress response. Kim E, et al. G3 (Bethesda), 2012 Aug. PMID 22908040, Free PMC Article
    4. Evidence that heat and ultraviolet radiation activate a common stress-response program in plants that is altered in the uvh6 mutant of Arabidopsis thaliana. Jenkins ME, et al. Plant Physiol, 1997 Dec. PMID 9414549, Free PMC Article
    5. Interactions between Arabidopsis DNA repair genes UVH6, DDB1A, and DDB2 during abiotic stress tolerance and floral development. Ly V, et al. Plant Sci, 2013 Dec. PMID 24157211

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UVH6 may be involved in the repair of strand breaks and excision repair, but it is unlikely that UVH6 is required for transgenerational increase in recombination frequency (HRF).
      Title: Genome stability in the uvh6 mutant of Arabidopsis thaliana.
    2. UVH6, DDB1A, and DDB2 all contribute to UV tolerance, heat tolerance and floral patterning.
      Title: Interactions between Arabidopsis DNA repair genes UVH6, DDB1A, and DDB2 during abiotic stress tolerance and floral development.
    3. The uvh6 and det1 act additively to regulate plant size and heat-induced cell death.(UVH6 protein)
      Title: Genetic interactions between Arabidopsis DET1 and UVH6 during development and abiotic stress response.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_100201.3
    NM_179253.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RAD3-like DNA-binding helicase protein
    NP_171818.1
    • ULTRAVIOLET HYPERSENSITIVE 6 (UVH6); FUNCTIONS IN: in 6 functions; INVOLVED IN: DNA repair, response to UV, response to heat; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type (InterPro:IPR014013), Xeroderma pigmentosum group D protein (InterPro:IPR001945), Helicase-like, DEXD box c2 type (InterPro:IPR006554), Helicase, ATP-dependent, c2 type (InterPro:IPR006555), DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (InterPro:IPR002464), DEAD2 (InterPro:IPR010614), DNA helicase (DNA repair), Rad3 type (InterPro:IPR013020), Protein of unknown function DUF1227 (InterPro:IPR010643); BEST Arabidopsis thaliana protein match is: RAD3-like DNA-binding helicase protein (TAIR:AT1G20720.1); Has 3290 Blast hits to 2576 proteins in 779 species: Archae - 308; Bacteria - 1186; Metazoa - 653; Fungi - 359; Plants - 198; Viruses - 2; Other Eukaryotes - 584 (source: NCBI BLink).
    NP_849584.1
    • ULTRAVIOLET HYPERSENSITIVE 6 (UVH6); FUNCTIONS IN: in 6 functions; INVOLVED IN: DNA repair, response to UV, response to heat; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type (InterPro:IPR014013), Xeroderma pigmentosum group D protein (InterPro:IPR001945), Helicase-like, DEXD box c2 type (InterPro:IPR006554), Helicase, ATP-dependent, c2 type (InterPro:IPR006555), DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (InterPro:IPR002464), DEAD2 (InterPro:IPR010614), DNA helicase (DNA repair), Rad3 type (InterPro:IPR013020), Protein of unknown function DUF1227 (InterPro:IPR010643); BEST Arabidopsis thaliana protein match is: RAD3-like DNA-binding helicase protein (TAIR:AT1G20720.1); Has 3290 Blast hits to 2576 proteins in 779 species: Archae - 308; Bacteria - 1186; Metazoa - 653; Fungi - 359; Plants - 198; Viruses - 2; Other Eukaryotes - 584 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      775527..780062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100201.3 → NP_171818.1  RAD3-like DNA-binding helicase protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171818.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W4M7, Q9SE44, Q9ZVS1
      UniProtKB/TrEMBL
      A0A178W4P7, A0A178W6E7, A0A5S9SCY3
      Conserved Domains (1) summary
      TIGR00604
      Location:7 → 714
      rad3; DNA repair helicase (rad3)

    2. NM_179253.1 → NP_849584.1  RAD3-like DNA-binding helicase protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849584.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W4M7, Q9SE44, Q9ZVS1
      UniProtKB/TrEMBL
      A0A178W4P7, A0A178W6E7, A0A5S9SCY3
      Conserved Domains (1) summary
      TIGR00604
      Location:7 → 714
      rad3; DNA repair helicase (rad3)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W4M7.1

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