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    HAC1 histone acetyltransferase of the CBP family 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844241, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HAC1
    Official Full Name
    histone acetyltransferase of the CBP family 1
    Primary source
    TAIR:AT1G79000
    Locus tag
    AT1G79000
    See related
    Araport:AT1G79000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS HISTONE ACETYLTRANSFERASE OF THE CBP FAMILY 1; ARABIDOPSIS THALIANA P300/CBP ACETYLTRANSFERASE-RELATED PROTEIN 2; ATHAC1; ATHPCAT2; histone acetyltransferase of the CBP family 1; P300/CBP ACETYLTRANSFERASE-RELATED PROTEIN 2; PCAT2; YUP8H12R.38; YUP8H12R_38
    Summary
    Homologous to CREB-binding protein, a co-activator of transcription with histone acetyl-transferase activity. No single prior lysine acetylation is sufficient to block HAC1 acetylation of the H3 or H4 peptides, suggesting that HAC1, HAC5, and HAC12 can acetylate any of several lysines present in the peptides. HAM2 acetylates histone H4 lysine 5. A plant line expressing an RNAi construct targeted against HAC1 has reduced rates of agrobacterium-mediated root transformation.
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    Genomic context

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    See HAC1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Sequence:
    Chromosome: 1; NC_003070.9 (29716350..29724748, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene uncharacterized protein Neighboring gene Alpha-helical ferredoxin Neighboring gene Enhancer of polycomb-like transcription factor protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeted expression of the arsenate reductase HAC1 identifies cell type specificity of arsenic metabolism and transport in plant roots. Fischer S, et al. J Exp Bot, 2021 Feb 2. PMID 33038235, Free PMC Article
    2. Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins. Bordoli L, et al. Nucleic Acids Res, 2001 Feb 1. PMID 11160878, Free PMC Article
    3. LEUNIG_HOMOLOG Mediates MYC2-Dependent Transcriptional Activation in Cooperation with the Coactivators HAC1 and MED25. You Y, et al. Plant Cell, 2019 Sep. PMID 31320481, Free PMC Article
    4. Role of plant CBP/p300-like genes in the regulation of flowering time. Han SK, et al. Plant J, 2007 Jan. PMID 17144897
    5. The CBP/p300 histone acetyltransferases function as plant-specific MEDIATOR subunits in Arabidopsis. Guo J, et al. J Integr Plant Biol, 2021 Apr. PMID 33325122

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198504.2
    NM_001334866.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-mediated transformation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase of the CBP family 1
    NP_001185433.1
    • histone acetyltransferase of the CBP family 1 (HAC1); FUNCTIONS IN: histone acetyltransferase activity, transcription cofactor activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Histone H3-K56 acetyltransferase, RTT109 (InterPro:IPR013178), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, TAZ-type (InterPro:IPR000197), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, ZZ-type (InterPro:IPR000433); BEST Arabidopsis thaliana protein match is: histone acetyltransferase of the CBP family 12 (TAIR:AT1G16710.1).
    NP_565197.3
    • histone acetyltransferase of the CBP family 1 (HAC1); FUNCTIONS IN: histone acetyltransferase activity, transcription cofactor activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Histone H3-K56 acetyltransferase, RTT109 (InterPro:IPR013178), Zinc finger, TAZ-type (InterPro:IPR000197), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, ZZ-type (InterPro:IPR000433); BEST Arabidopsis thaliana protein match is: histone acetyltransferase of the CBP family 12 (TAIR:AT1G16710.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29716350..29724748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106550.4 → NP_565197.3  histone acetyltransferase of the CBP family 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565197.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64548, Q9C5X9
      UniProtKB/TrEMBL
      A0A178WJZ4, A0A5S9WVM3
      Conserved Domains (4) summary
      smart00551
      Location:631 → 709
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:1522 → 1567
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15614
      Location:991 → 1063
      PHD_HAC_like; PHD finger found in Arabidopsis thaliana histone acetyltransferases (HATs) HAC and similar proteins
      cl02120
      Location:1122 → 1343
      HAT_KAT11; Histone acetylation protein

    2. NM_001198504.2 → NP_001185433.1  histone acetyltransferase of the CBP family 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185433.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WVM3, A0A654F157, F4IDH2
      Conserved Domains (4) summary
      smart00551
      Location:631 → 709
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:1522 → 1567
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15614
      Location:991 → 1063
      PHD_HAC_like; PHD finger found in Arabidopsis thaliana histone acetyltransferases (HATs) HAC and similar proteins
      cl02120
      Location:1122 → 1360
      HAT_KAT11; Histone acetylation protein

    3. NM_001334866.1 → NP_001322202.1  histone acetyltransferase of the CBP family 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ATA1, A0A5S9WVM3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5X9.2

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