U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SRX sulfiredoxin [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840004, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SRX
    Official Full Name
    sulfiredoxin
    Primary source
    TAIR:AT1G31170
    Locus tag
    AT1G31170
    See related
    Araport:AT1G31170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSRX; F28K20.12; F28K20_12; sulfiredoxin; SULFIREDOXIN
    Summary
    encodes a cysteine-sulfinic acid reductase (sulfiredoxin - EC 1.8.98.2) capable of reducing overoxidized plastidic 2-Cys-Prx involved in peroxide detoxification and response to oxidative stress
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SRX in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (11133410..11135189)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The crystal structure of sulfiredoxin from Arabidopsis thaliana revealed a more robust antioxidant mechanism in plants. Liu M, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31604522
    2. Dual functions of Arabidopsis sulfiredoxin: acting as a redox-dependent sulfinic acid reductase and as a redox-independent nuclease enzyme. Chi YH, et al. FEBS Lett, 2012 Sep 21. PMID 22967894
    3. The dual-targeted plant sulfiredoxin retroreduces the sulfinic form of atypical mitochondrial peroxiredoxin. Iglesias-Baena I, et al. Plant Physiol, 2011 Feb. PMID 21139087, Free PMC Article
    4. The Arabidopsis thaliana sulfiredoxin is a plastidic cysteine-sulfinic acid reductase involved in the photooxidative stress response. Rey P, et al. Plant J, 2007 Feb. PMID 17217469
    5. The contribution of NADPH thioredoxin reductase C (NTRC) and sulfiredoxin to 2-Cys peroxiredoxin overoxidation in Arabidopsis thaliana chloroplasts. Puerto-Galán L, et al. J Exp Bot, 2015 May. PMID 25560178, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Srx crystal structure shows ADP and ATP binding sites.
      Title: The crystal structure of sulfiredoxin from Arabidopsis thaliana revealed a more robust antioxidant mechanism in plants.
    2. An Arabidopsis thaliana double knockout mutant lacking NTRC and Srx shows a phenotype similar to the ntrc mutant, while the srx mutant resembles wild-type plants. NTRC deficiency causes reduced overoxidation of 2-Cys peroxiredoxins.
      Title: The contribution of NADPH thioredoxin reductase C (NTRC) and sulfiredoxin to 2-Cys peroxiredoxin overoxidation in Arabidopsis thaliana chloroplasts.
    3. Srx functions as a nuclease enzyme that can use single-stranded and double-stranded DNAs as substrates.
      Title: Dual functions of Arabidopsis sulfiredoxin: acting as a redox-dependent sulfinic acid reductase and as a redox-independent nuclease enzyme.
    4. Srx is present in mitochondria regardless of the redox state. It retroreduces the inactive sulfinic form of atypical Prx IIF.
      Title: The dual-targeted plant sulfiredoxin retroreduces the sulfinic form of atypical mitochondrial peroxiredoxin.
    5. AtSrx is a chloroplastic enzyme displaying sulfinic acid reductase activity.
      Title: The Arabidopsis thaliana sulfiredoxin is a plastidic cysteine-sulfinic acid reductase involved in the photooxidative stress response.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001084168.1
    NM_001084169.1
    NM_001332946.1
    NM_102855.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on a sulfur group of donors IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    sulfiredoxin
    NP_001077637.1
    • sulfiredoxin (SRX); CONTAINS InterPro DOMAIN/s: Sulfiredoxin (InterPro:IPR016692), ParB-like nuclease (InterPro:IPR003115); Has 313 Blast hits to 313 proteins in 133 species: Archae - 0; Bacteria - 130; Metazoa - 88; Fungi - 17; Plants - 42; Viruses - 2; Other Eukaryotes - 34 (source: NCBI BLink).
    NP_001077638.1
    • sulfiredoxin (SRX); CONTAINS InterPro DOMAIN/s: Sulfiredoxin (InterPro:IPR016692), ParB-like nuclease (InterPro:IPR003115); Has 206 Blast hits to 206 proteins in 81 species: Archae - 0; Bacteria - 45; Metazoa - 89; Fungi - 3; Plants - 42; Viruses - 2; Other Eukaryotes - 25 (source: NCBI BLink).
    NP_001185121.1
    • sulfiredoxin (SRX); CONTAINS InterPro DOMAIN/s: ParB-like nuclease (InterPro:IPR003115).
    NP_564375.1
    • sulfiredoxin (SRX); CONTAINS InterPro DOMAIN/s: Sulfiredoxin (InterPro:IPR016692), ParB-like nuclease (InterPro:IPR003115); Has 313 Blast hits to 313 proteins in 133 species: Archae - 0; Bacteria - 130; Metazoa - 88; Fungi - 17; Plants - 42; Viruses - 2; Other Eukaryotes - 34 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11133410..11135189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198192.1 → NP_001185121.1  sulfiredoxin [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185121.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I7W2
      Conserved Domains (2) summary
      smart00470
      Location:41 → 122
      ParB; ParB-like nuclease domain
      COG1475
      Location:39 → 121
      Spo0J; Chromosome segregation protein Spo0J, contains ParB-like nuclease domain [Cell cycle control, cell division, chromosome partitioning]

    2. NM_102855.4 → NP_564375.1  sulfiredoxin [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564375.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MS24, Q8GY89, Q8LC51, Q9SA12
      UniProtKB/TrEMBL
      A0A178WH65, A0A5S9WJJ1
      Conserved Domains (1) summary
      cd16395
      Location:40 → 124
      Srx; Sulfiredoxin reactivates peroxiredoxins after oxidative inactivation

    3. NM_001332946.1 → NP_001321339.1  sulfiredoxin [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQM5
      Conserved Domains (1) summary
      cd16395
      Location:40 → 121
      Srx; Sulfiredoxin reactivates peroxiredoxins after oxidative inactivation

    4. NM_001084169.1 → NP_001077638.1  sulfiredoxin [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077638.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GY89
      Conserved Domains (2) summary
      smart00470
      Location:41 → 119
      ParB; ParB-like nuclease domain
      COG1475
      Location:39 → 119
      Spo0J; Chromosome segregation protein Spo0J, contains ParB-like nuclease domain [Cell cycle control, cell division, chromosome partitioning]

    5. NM_001084168.1 → NP_001077637.1  sulfiredoxin [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077637.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MS24, Q8GY89, Q8LC51, Q9SA12
      UniProtKB/TrEMBL
      A0A178WH65, A0A5S9WJJ1
      Conserved Domains (1) summary
      cd16395
      Location:40 → 124
      Srx; Sulfiredoxin reactivates peroxiredoxins after oxidative inactivation
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GY89.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools