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    PUB18 plant U-box 18 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837597, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PUB18
    Official Full Name
    plant U-box 18
    Primary source
    TAIR:AT1G10560
    Locus tag
    AT1G10560
    See related
    Araport:AT1G10560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA PLANT U-BOX 18; ATPUB18; plant U-box 18; T10O24.19; T10O24_19
    Summary
    Encodes a protein containing a UND, a U-box, and an ARM domain. This protein has E3 ubiquitin ligase activity based on in vitro assays.
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    Genomic context

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    See PUB18 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (3484399..3486965)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene nucleobase-ascorbate transporter 8 Neighboring gene xyloglucan:xyloglucosyl transferase 33 Neighboring gene Cysteine proteinases superfamily protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of four Arabidopsis U-box E3 ubiquitin ligases in negative regulation of abscisic acid-mediated drought stress responses. Seo DH, et al. Plant Physiol, 2012 Sep. PMID 22829319, Free PMC Article
    2. Plant U-box armadillo repeat proteins AtPUB18 and AtPUB19 are involved in salt inhibition of germination in Arabidopsis. Bergler J, et al. Plant Biol (Stuttg), 2011 Sep. PMID 21815976
    3. The N-Terminal UND Motif of the Arabidopsis U-Box E3 Ligase PUB18 Is Critical for the Negative Regulation of ABA-Mediated Stomatal Movement and Determines Its Ubiquitination Specificity for Exocyst Subunit Exo70B1. Seo DH, et al. Plant Cell, 2016 Dec. PMID 27956469, Free PMC Article
    4. A large complement of the predicted Arabidopsis ARM repeat proteins are members of the U-box E3 ubiquitin ligase family. Mudgil Y, et al. Plant Physiol, 2004 Jan. PMID 14657406, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Both AtPUB18 and AtPUB19 participate in negative regulation of abscisic acid-dependent drought stress responses.
      Title: Roles of four Arabidopsis U-box E3 ubiquitin ligases in negative regulation of abscisic acid-mediated drought stress responses.
    Submit: New GeneRIF Correction

    General gene information

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    NM_100931.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of seed germination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    plant U-box 18
    NP_172526.1
    • plant U-box 18 (PUB18); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: protein ubiquitination; LOCATED IN: ubiquitin ligase complex; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 4 anthesis, LP.10 ten leaves visible, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), U box domain (InterPro:IPR003613), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: ARM repeat superfamily protein (TAIR:AT1G60190.1); Has 3089 Blast hits to 2773 proteins in 228 species: Archae - 0; Bacteria - 22; Metazoa - 252; Fungi - 338; Plants - 2172; Viruses - 3; Other Eukaryotes - 302 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3484399..3486965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100931.3 → NP_172526.1  plant U-box 18 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172526.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S9I5, Q9XIJ5
      UniProtKB/TrEMBL
      A0A178WAU7, A0A5S9TN25, A0A7G2DRS1
      Conserved Domains (5) summary
      smart00504
      Location:291 → 351
      Ubox; Modified RING finger domain
      PLN03200
      Location:502 → 676
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:425 → 457
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:422 → 458
      Arm; Armadillo/beta-catenin-like repeat
      cl05301
      Location:26 → 165
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XIJ5.1

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