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    CuAO1 Copper amine oxidase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842580, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CuAO1
    Official Full Name
    Copper amine oxidase family protein
    Primary source
    TAIR:AT1G62810
    Locus tag
    AT1G62810
    See related
    Araport:AT1G62810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    COPPER AMINE OXIDASE1; F23N19.18; F23N19_18
    Summary
    Encodes COPPER AMINE OXIDASE1 (CuAO1). Contributes to abscisic acid- and polyamine-induced nitric oxide biosynthesis and abscisic acid signal transduction.
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    Genomic context

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    See CuAO1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (23257610..23262002, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene aspartate aminotransferase 4 Neighboring gene ncRNA Neighboring gene Calcium-binding EF-hand family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COPPER AMINE OXIDASE1 (CuAO1) of Arabidopsis thaliana contributes to abscisic acid- and polyamine-induced nitric oxide biosynthesis and abscisic acid signal transduction. Wimalasekera R, et al. Mol Plant, 2011 Jul. PMID 21471330
    2. Copper amine oxidase and phospholipase D act independently in abscisic acid (ABA)-induced stomatal closure in Vicia faba and Arabidopsis. Qu Y, et al. J Plant Res, 2014 Jul. PMID 24817219
    3. Peroxisomal CuAOζ and its product H2O2 regulate the distribution of auxin and IBA-dependent lateral root development in Arabidopsis. Qu Y, et al. J Exp Bot, 2017 Oct 13. PMID 28992128
    4. Copper-containing amine oxidases contribute to terminal polyamine oxidation in peroxisomes and apoplast of Arabidopsis thaliana. Planas-Portell J, et al. BMC Plant Biol, 2013 Aug 5. PMID 23915037, Free PMC Article
    5. Developmental, hormone- and stress-modulated expression profiles of four members of the Arabidopsis copper-amine oxidase gene family. Fraudentali I, et al. Plant Physiol Biochem, 2020 Feb. PMID 31862580

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggest a peroxisomal ROS-based auxin signaling pathway involving spatiotemporal-dependent CuAOzeta functional regulation of PIN2 homeostasis, auxin distribution, and LR development.
      Title: Peroxisomal CuAOζ and its product H2O2 regulate the distribution of auxin and IBA-dependent lateral root development in Arabidopsis.
    2. Ablation of guard cell-expressed copper amine oxidase gamma or phospholipase Dalpha1 gene retarded abscisic acid-induced H2O2 generation and stomatal closure.
      Title: Copper amine oxidase and phospholipase D act independently in abscisic acid (ABA)-induced stomatal closure in Vicia faba and Arabidopsis.
    3. AtCuAO1 is an extracellular protein, while AtCuAO2 and AtCuAO3 are localized in peroxisomes.
      Title: Copper-containing amine oxidases contribute to terminal polyamine oxidation in peroxisomes and apoplast of Arabidopsis thaliana.
    4. COPPER AMINE OXIDASE1 (CuAO1) contributes to abscisic acid- and polyamine-induced nitric oxide biosynthesis and abscisic acid signal transduction.
      Title: COPPER AMINE OXIDASE1 (CuAO1) of Arabidopsis thaliana contributes to abscisic acid- and polyamine-induced nitric oxide biosynthesis and abscisic acid signal transduction.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_104959.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables aliphatic amine oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables primary methylamine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in putrescine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to molecule of bacterial origin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to putrescine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to salicylic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    NOT involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Copper amine oxidase family protein
    NP_176469.1
    • Copper amine oxidase family protein; FUNCTIONS IN: primary amine oxidase activity, quinone binding, copper ion binding; INVOLVED IN: oxidation reduction, amine metabolic process; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Copper amine oxidase, N-terminal (InterPro:IPR016182), Copper amine oxidase, N2-terminal (InterPro:IPR015800), Copper amine oxidase, N2/N3-terminal (InterPro:IPR015801), Copper amine oxidase, N3-terminal (InterPro:IPR015802), Copper amine oxidase (InterPro:IPR000269), Copper amine oxidase, C-terminal (InterPro:IPR015798); BEST Arabidopsis thaliana protein match is: Copper amine oxidase family protein (TAIR:AT3G43670.1); Has 1558 Blast hits to 1554 proteins in 277 species: Archae - 14; Bacteria - 381; Metazoa - 247; Fungi - 454; Plants - 245; Viruses - 0; Other Eukaryotes - 217 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      23257610..23262002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104959.4 → NP_176469.1  Copper amine oxidase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176469.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84W14, Q8H1H9, Q9SI68
      UniProtKB/TrEMBL
      A0A178W5U0
      Conserved Domains (4) summary
      PLN02566
      Location:60 → 694
      PLN02566; amine oxidase (copper-containing)
      pfam01179
      Location:278 → 697
      Cu_amine_oxid; Copper amine oxidase, enzyme domain
      pfam02727
      Location:60 → 142
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:152 → 250
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H1H9.1

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