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    DCP1 decapping 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837357, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DCP1
    Official Full Name
    decapping 1
    Primary source
    TAIR:AT1G08370
    Locus tag
    AT1G08370
    See related
    Araport:AT1G08370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATDCP1; decapping 1
    Summary
    Encodes DCP1 involved in mRNA decapping. DCP1 forms a mRNA decapping complex with DCP2 (At5g13570) and VCS (VARICOSE) (At3g13300). However, unlike DCP2, DCP1 itself does not have mRNA decapping activity in vitro. DCP1, DCP2 and VCS colocalize in cytoplasmic loci, which are putative Arabidopsis mRNA processing bodies. Null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. These mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology. The protein was shown by immunoprecipitation not to interact with DCP2.
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    Genomic context

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    See DCP1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (2638037..2640663)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein Neighboring gene Endomembrane protein 70 protein family Neighboring gene Ribosomal protein L1p/L10e family Neighboring gene photosystem I subunit O Neighboring gene recQ-mediated instability-like protein Neighboring gene RINT-1 / TIP-1 family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NB-LRR signaling induces translational repression of viral transcripts and the formation of RNA processing bodies through mechanisms differing from those activated by UV stress and RNAi. Meteignier LV, et al. J Exp Bot, 2016 Apr. PMID 26889008
    2. Diffuse decapping enzyme DCP2 accumulates in DCP1 foci under heat stress in Arabidopsis thaliana. Motomura K, et al. Plant Cell Physiol, 2015 Jan. PMID 25339350
    3. Characterization of Arabidopsis decapping proteins AtDCP1 and AtDCP2, which are essential for post-embryonic development. Iwasaki S, et al. FEBS Lett, 2007 May 29. PMID 17485080
    4. Arabidopsis TAF15b Localizes to RNA Processing Bodies and Contributes to snc1-Mediated Autoimmunity. Dong OX, et al. Mol Plant Microbe Interact, 2016 Apr. PMID 26713351
    5. The role of decapping proteins in the miRNA accumulation in Arabidopsis thaliana. Motomura K, et al. RNA Biol, 2012 May. PMID 22614834

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DCP1 and DCP2 respond differently to environmental changes, indicating that P-bodies have diverse DCP1 and DCP2 proportions depending on environmental conditions.
      Title: Diffuse decapping enzyme DCP2 accumulates in DCP1 foci under heat stress in Arabidopsis thaliana.
    2. By performing coexpression studies with AtDCP1, dominant-negative myosin fragments, as well as functional full-length myosin XI-K, the association of P-bodies and myosins was analyzed in detail.
      Title: Processing-body movement in Arabidopsis depends on an interaction between myosins and DECAPPING PROTEIN1.
    3. Seedling lethal phenotypes in dcp1, dcp2 and vcs mutants are caused the disruption of miRNA-mediated gene regulation.
      Title: The role of decapping proteins in the miRNA accumulation in Arabidopsis thaliana.
    4. These results suggest that mRNA decapping through MPK6-DCP1-DCP5 pathway serves as a rapid response to dehydration stress in Arabidopsis.
      Title: Dehydration stress activates Arabidopsis MPK6 to signal DCP1 phosphorylation.
    5. DCP5 associates with DCP1 and DCP2 and is required for mRNA decapping in vivo.
      Title: Arabidopsis decapping 5 is required for mRNA decapping, P-body formation, and translational repression during postembryonic development.
    6. AtDCP1 and is essential for post-embryonic development and supplies new insights into the role of decapping-dependent mRNA turnover.
      Title: Characterization of Arabidopsis decapping proteins AtDCP1 and AtDCP2, which are essential for post-embryonic development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_100710.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within deadenylation-independent decapping of nuclear-transcribed mRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in P-body NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    decapping 1
    NP_563814.1
    • decapping 1 (DCP1); CONTAINS InterPro DOMAIN/s: Dcp1-like decapping (InterPro:IPR010334); Has 3561 Blast hits to 2917 proteins in 377 species: Archae - 4; Bacteria - 239; Metazoa - 1310; Fungi - 561; Plants - 741; Viruses - 142; Other Eukaryotes - 564 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2638037..2640663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100710.4 → NP_563814.1  decapping 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563814.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64895, Q9SJF3
      UniProtKB/TrEMBL
      A0A178WLN9
      Conserved Domains (1) summary
      pfam06058
      Location:16 → 125
      DCP1; Dcp1-like decapping family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SJF3.2

    Gene LinkOut

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