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    TRB1 telomere repeat binding factor 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841418, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TRB1
    Official Full Name
    telomere repeat binding factor 1
    Primary source
    TAIR:AT1G49950
    Locus tag
    AT1G49950
    See related
    Araport:AT1G49950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATTRB1; F2J10.16; F2J10_16; telomere repeat binding factor 1; TELOMERE REPEAT BINDING FACTOR 1
    Summary
    Encodes a telomeric DNA binding protein. In vitro, an N-terminal Myb domain enables it to interact with double-stranded telomeric repeats.
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    Genomic context

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    See TRB1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (18494029..18497318, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Xanthine/uracil permease family protein Neighboring gene CLP protease proteolytic subunit 1 Neighboring gene photosystem I reaction center subunit N

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Telomere binding protein TRB1 is associated with promoters of translation machinery genes in vivo. Schrumpfová PP, et al. Plant Mol Biol, 2016 Jan. PMID 26597966
    2. Functional characterization of domains in AtTRB1, a putative telomere-binding protein in Arabidopsis thaliana. Mozgová I, et al. Phytochemistry, 2008 Jun. PMID 18479720
    3. Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes. Zhou Y, et al. Plant Cell, 2016 Jan. PMID 26721861, Free PMC Article
    4. AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association with chromatin. Dvorácková M, et al. Plant J, 2010 Feb. PMID 19947985
    5. Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana. Schrumpfová PP, et al. FEBS Lett, 2008 Apr 30. PMID 18387366

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRB1 shows a specific genome-wide distribution pattern which suggests its role in regulation of genes involved in biogenesis of the translational machinery, in addition to its preferential telomeric localization.
      Title: Telomere binding protein TRB1 is associated with promoters of translation machinery genes in vivo.
    2. AtTRB1 is highly dynamic during interphase. The histone-like domain and the Myb domain can both direct the protein to the nucleolus.
      Title: AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association with chromatin.
    3. DNA-protein interaction of the full-length and truncated variants of AtTRB1, a Single-Myb-Histone-family member with a typical structure
      Title: Functional characterization of domains in AtTRB1, a putative telomere-binding protein in Arabidopsis thaliana.
    4. The domains responsible for that interaction AtTRB1 and AtPOT1b were identified.
      Title: Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_103882.4
    NM_179458.3
    NM_202269.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables double-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    telomere repeat binding factor 1
    NP_564559.1
    • telomere repeat binding factor 1 (TRB1); FUNCTIONS IN: DNA binding, protein homodimerization activity, sequence-specific DNA binding transcription factor activity, double-stranded telomeric DNA binding; INVOLVED IN: in 8 processes; LOCATED IN: nucleus, nucleosome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), SANT, DNA-binding (InterPro:IPR001005), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Histone H1/H5 (InterPro:IPR005818), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: telomere repeat binding factor 3 (TAIR:AT3G49850.1); Has 1029 Blast hits to 1009 proteins in 184 species: Archae - 7; Bacteria - 85; Metazoa - 120; Fungi - 83; Plants - 636; Viruses - 0; Other Eukaryotes - 98 (source: NCBI BLink).
    NP_849789.1
    • telomere repeat binding factor 1 (TRB1); FUNCTIONS IN: DNA binding, protein homodimerization activity, sequence-specific DNA binding transcription factor activity, double-stranded telomeric DNA binding; INVOLVED IN: in 8 processes; LOCATED IN: nucleus, nucleosome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), SANT, DNA-binding (InterPro:IPR001005), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Histone H1/H5 (InterPro:IPR005818), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: telomere repeat binding factor 3 (TAIR:AT3G49850.1); Has 1029 Blast hits to 1009 proteins in 184 species: Archae - 7; Bacteria - 85; Metazoa - 120; Fungi - 83; Plants - 636; Viruses - 0; Other Eukaryotes - 98 (source: NCBI BLink).
    NP_973998.1
    • telomere repeat binding factor 1 (TRB1); FUNCTIONS IN: DNA binding, protein homodimerization activity, sequence-specific DNA binding transcription factor activity, double-stranded telomeric DNA binding; INVOLVED IN: in 8 processes; LOCATED IN: nucleus, nucleosome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), SANT, DNA-binding (InterPro:IPR001005), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Histone H1/H5 (InterPro:IPR005818), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: telomere repeat binding factor 3 (TAIR:AT3G49850.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18494029..18497318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103882.4 → NP_564559.1  telomere repeat binding factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564559.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LA70, Q8VWK4, Q8VX39, Q9LPL9
      UniProtKB/TrEMBL
      A0A178W8N7, A0A5S9WNL0
      Conserved Domains (3) summary
      smart00526
      Location:113 → 178
      H15; Domain in histone families 1 and 5
      smart00717
      Location:5 → 56
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11660
      Location:6 → 56
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

    2. NM_179458.3 → NP_849789.1  telomere repeat binding factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849789.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LA70, Q8VWK4, Q8VX39, Q9LPL9
      UniProtKB/TrEMBL
      A0A178W8N7, A0A5S9WNL0
      Conserved Domains (3) summary
      smart00526
      Location:113 → 178
      H15; Domain in histone families 1 and 5
      smart00717
      Location:5 → 56
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11660
      Location:6 → 56
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

    3. NM_202269.2 → NP_973998.1  telomere repeat binding factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973998.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LA70, Q8VWK4, Q8VX39, Q9LPL9
      UniProtKB/TrEMBL
      A0A178W8N7, A0A5S9WNL0
      Conserved Domains (3) summary
      smart00526
      Location:113 → 178
      H15; Domain in histone families 1 and 5
      smart00717
      Location:5 → 56
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11660
      Location:6 → 56
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VWK4.1

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