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    SNRK2.4 Protein kinase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837637, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SNRK2.4
    Official Full Name
    Protein kinase superfamily protein
    Primary source
    TAIR:AT1G10940
    Locus tag
    AT1G10940
    See related
    Araport:AT1G10940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS SERINE/THREONINE KINASE 1; ARABIDOPSIS SKP1 HOMOLOGUE 1; ASK1; SNF1-related protein kinase 2.4; SNRK2-4; SRK2A; SUCROSE NONFERMENTING 1-RELATED PROTEIN KINASE 2-4
    Summary
    Encodes a plant protein kinase similar to the calcium/calmodulin-dependent protein kinase subfamily and the SNF1 kinase subfamily (SnRK2) whose activity is activated by ionic (salt) and non-ionic (mannitol) osmotic stress. Kinase activity of its homolog in tobacco is induced by hyperosmotic condition within 1 minute.
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    Genomic context

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    See SNRK2.4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (3655673..3658612, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol-4-phosphate 5-kinase family protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene NB-ARC domain-containing disease resistance protein Neighboring gene DNA helicase (RECQl4A) Neighboring gene transmembrane nine 1 Neighboring gene ferredoxin 1 Neighboring gene zinc transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and functional characterization of the Arabidopsis Snf1-related protein kinase SnRK2.4 phosphatidic acid-binding domain. Julkowska MM, et al. Plant Cell Environ, 2015 Mar. PMID 25074439
    2. SNF1-related protein kinases type 2 are involved in plant responses to cadmium stress. Kulik A, et al. Plant Physiol, 2012 Oct. PMID 22885934, Free PMC Article
    3. SNF1-Related Protein Kinases SnRK2.4 and SnRK2.10 Modulate ROS Homeostasis in Plant Response to Salt Stress. Szymańska KP, et al. Int J Mol Sci, 2019 Jan 2. PMID 30609769, Free PMC Article
    4. Phosphatase ABI1 and okadaic acid-sensitive phosphoprotein phosphatases inhibit salt stress-activated SnRK2.4 kinase. Krzywińska E, et al. BMC Plant Biol, 2016 Jun 13. PMID 27297076, Free PMC Article
    5. The Snf1-related protein kinases SnRK2.4 and SnRK2.10 are involved in maintenance of root system architecture during salt stress. McLoughlin F, et al. Plant J, 2012 Nov. PMID 22738204, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis sucrose non-fermenting-1-related protein kinase AtSnRK2.4 interacts with a transcription factor, AtMYB21, that is involved in salt tolerance.
      Title: The Arabidopsis sucrose non-fermenting-1-related protein kinase AtSnRK2.4 interacts with a transcription factor, AtMYB21, that is involved in salt tolerance.
    2. SNRK2.4 is involved in the regulation of ROS homeostasis in response to salinity.
      Title: SNF1-Related Protein Kinases SnRK2.4 and SnRK2.10 Modulate ROS Homeostasis in Plant Response to Salt Stress.
    3. Phosphatase ABI1 and okadaic acid-sensitive phosphatases of the PPP family are negative regulators of salt stress-activated SnRK2.4.
      Title: Phosphatase ABI1 and okadaic acid-sensitive phosphoprotein phosphatases inhibit salt stress-activated SnRK2.4 kinase.
    4. Biochemical characterization of the PA-SnRK2.4 interaction and shows that functionality of the SnRK2.4 primary PA-binding domain (PABD) affects root development.
      Title: Identification and functional characterization of the Arabidopsis Snf1-related protein kinase SnRK2.4 phosphatidic acid-binding domain.
    5. SnRK2.4 and -2.10 play a role in root growth and architecture in saline conditions.
      Title: The Snf1-related protein kinases SnRK2.4 and SnRK2.10 are involved in maintenance of root system architecture during salt stress.
    6. SnRK2.4 regulates level of reactive oxygen species produced in Arabidopsis roots in response to cadmium ions.
      Title: SNF1-related protein kinases type 2 are involved in plant responses to cadmium stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001035944.2
    NM_100969.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within primary root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase superfamily protein
    NP_001031021.2
    • Protein kinase superfamily protein; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like, plant (InterPro:IPR015740); BEST Arabidopsis thaliana protein match is: SNF1-related protein kinase 2.10 (TAIR:AT1G60940.2).
    NP_172563.1
    • SNF1-related protein kinase 2.4 (SNRK2.4); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Serine/threonine-protein kinase-like, plant (InterPro:IPR015740); BEST Arabidopsis thaliana protein match is: SNF1-related protein kinase 2.10 (TAIR:AT1G60940.2); Has 111412 Blast hits to 109617 proteins in 3021 species: Archae - 114; Bacteria - 12857; Metazoa - 41430; Fungi - 12032; Plants - 25317; Viruses - 521; Other Eukaryotes - 19141 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3655673..3658612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100969.4 → NP_172563.1  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172563.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P43291
      UniProtKB/TrEMBL
      A0A178W429, A0A178W474, A0A5S9TQU3, A0A5S9WRD1
      Conserved Domains (1) summary
      cd14662
      Location:3 → 259
      STKc_SnRK2; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2

    2. NM_001035944.2 → NP_001031021.2  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031021.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W429, A0A5S9WRD1, F4I7B6
      Conserved Domains (2) summary
      smart00220
      Location:4 → 268
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14662
      Location:3 → 267
      STKc_SnRK2; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43291.1

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