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    PFD6 prefoldin 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839878, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PFD6
    Official Full Name
    prefoldin 6
    Primary source
    TAIR:AT1G29990
    Locus tag
    AT1G29990
    See related
    Araport:AT1G29990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    prefoldin 6; T1P2.3; T1P2_3
    Summary
    Encodes a cytoplastic protein with similarity to yeast prefoldin6, a subunit of the prefoldin complex. The PFD complex is thought to function along with the TCP ring complex to properly fold microtubule proteins.
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    Genomic context

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    See PFD6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (10507533..10509151)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene choice-of-anchor C domain protein, putative (Protein of unknown function, DUF642) Neighboring gene alpha-mannosidase 3 Neighboring gene Intron maturase, type II family protein Neighboring gene hypothetical protein (Protein of unknown function, DUF538)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The unconventional prefoldin RPB5 interactor mediates the gravitropic response by modulating cytoskeleton organization and auxin transport in Arabidopsis. Yang Y, et al. J Integr Plant Biol, 2022 Oct. PMID 35943836
    2. Dynamic regulation of cortical microtubule organization through prefoldin-DELLA interaction. Locascio A, et al. Curr Biol, 2013 May 6. PMID 23583555
    3. Prefoldin 6 is required for normal microtubule dynamics and organization in Arabidopsis. Gu Y, et al. Proc Natl Acad Sci U S A, 2008 Nov 18. PMID 19004800, Free PMC Article
    4. Prefoldins 3 and 5 play an essential role in Arabidopsis tolerance to salt stress. Rodríguez-Milla MA, et al. Mol Plant, 2009 May. PMID 19825635
    5. Prefoldins contribute to maintaining the levels of the spliceosome LSM2-8 complex through Hsp90 in Arabidopsis. Esteve-Bruna D, et al. Nucleic Acids Res, 2020 Jun 19. PMID 32396196, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_102739.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to gibberellin stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cortical microtubule organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    part_of prefoldin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of prefoldin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prefoldin 6
    NP_174292.2
    • prefoldin 6 (PFD6); FUNCTIONS IN: unfolded protein binding; INVOLVED IN: protein folding, cortical microtubule organization; LOCATED IN: prefoldin complex, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Prefoldin beta-like (InterPro:IPR002777), Prefoldin (InterPro:IPR009053); Has 469 Blast hits to 469 proteins in 236 species: Archae - 55; Bacteria - 6; Metazoa - 162; Fungi - 121; Plants - 38; Viruses - 0; Other Eukaryotes - 87 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10507533..10509151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102739.4 → NP_174292.2  prefoldin 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174292.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2HIK4, Q8GYJ1, Q9C8S0
      UniProtKB/TrEMBL
      A0A178WBU1, A0A5S9WCS9, A0A654EE12
      Conserved Domains (1) summary
      cd00632
      Location:13 → 117
      Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2HIK4.1

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