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    NRB4 mediator of RNA polymerase II transcription subunit 15a-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838147, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NRB4
    Official Full Name
    mediator of RNA polymerase II transcription subunit 15a-like protein
    Primary source
    TAIR:AT1G15780
    Locus tag
    AT1G15780
    See related
    Araport:AT1G15780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F7H2.12; F7H2_12; Non-Recognition-of-BTH 4
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    Genomic context

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    See NRB4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (5430040..5436618, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene mediator of RNA polymerase II transcription subunit Neighboring gene mediator of RNA polymerase II transcription subunit Neighboring gene mediator of RNA polymerase II transcription subunit 15a-like protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-recognition-of-BTH4, an Arabidopsis mediator subunit homolog, is necessary for development and response to salicylic acid. Canet JV, et al. Plant Cell, 2012 Oct. PMID 23064321, Free PMC Article
    2. KIX domain of AtMed15a, a Mediator subunit of Arabidopsis, is required for its interaction with different proteins. Kumar V, et al. Plant Signal Behav, 2018 Feb 1. PMID 29341856, Free PMC Article
    3. The Mediator Complex MED15 Subunit Mediates Activation of Downstream Lipid-Related Genes by the WRINKLED1 Transcription Factor. Kim MJ, et al. Plant Physiol, 2016 Jul. PMID 27246098, Free PMC Article
    4. Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit. Bäckström S, et al. Mol Cell, 2007 Jun 8. PMID 17560376
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. At1g15780 is part of Mediator complex and transcriptionally regulates glycolysis-related and fatty acid biosynthetic genes during embryogenesis.MED15 was recruited to the promoters of WRI1 target genes.
      Title: The Mediator Complex MED15 Subunit Mediates Activation of Downstream Lipid-Related Genes by the WRINKLED1 Transcription Factor.
    2. NRB4 (At1g15780) functions downstream of NPR1 to regulate the SA response.
      Title: Non-recognition-of-BTH4, an Arabidopsis mediator subunit homolog, is necessary for development and response to salicylic acid.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001332183.1
    NM_001332184.1
    NM_101446.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 15a-like protein
    NP_173030.1
    • unknown protein; BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT2G10440.1); Has 103701 Blast hits to 43153 proteins in 1828 species: Archae - 30; Bacteria - 7385; Metazoa - 38639; Fungi - 11531; Plants - 7727; Viruses - 307; Other Eukaryotes - 38082 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5430040..5436618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101446.4 → NP_173030.1  mediator of RNA polymerase II transcription subunit 15a-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173030.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I171, Q56WT7, Q9LMQ6
      UniProtKB/TrEMBL
      A0A654EA43
      Conserved Domains (1) summary
      pfam16987
      Location:25 → 100
      KIX_2; KIX domain

    2. NM_001332183.1 → NP_001321151.1  mediator of RNA polymerase II transcription subunit 15a-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQ17, A0A654EA43

    3. NM_001332184.1 → NP_001321150.1  mediator of RNA polymerase II transcription subunit 15a-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQ03, A0A654EA43
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4I171.1

    Gene LinkOut

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