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    DMS11 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838492, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DMS11
    Official Full Name
    Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein
    Primary source
    TAIR:AT1G19100
    Locus tag
    AT1G19100
    See related
    Araport:AT1G19100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMORC6; DEFECTIVE IN MERISTEM SILENCING 11; F14D16.25; F14D16_25; Microrchidia 6; MORC6
    Summary
    Encodes a member of the conserved Microrchidia (MORC) adenosine triphosphatase (ATPase) family, predicted to catalyze alterations in chromosome superstructure. Required for heterochromatin condensation and gene silencing.
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    Genomic context

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    See DMS11 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    20
    Sequence:
    Chromosome: 1; NC_003070.9 (6594883..6601355)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene receptor-like serine/threonine kinase 2 Neighboring gene inter-alpha-trypsin inhibitor heavy chain-like protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The stochastic silencing phenotype of Arabidopsis morc6 mutants reveals a role in efficient RNA-directed DNA methylation. Brabbs TR, et al. Plant J, 2013 Sep. PMID 23675613
    2. The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation. Li Z, et al. Nat Commun, 2023 Jul 12. PMID 37438334, Free PMC Article
    3. Involvement of a GHKL ATPase in RNA-directed DNA methylation in Arabidopsis thaliana. Lorković ZJ, et al. Curr Biol, 2012 May 22. PMID 22560611
    4. MORC family ATPases required for heterochromatin condensation and gene silencing. Moissiard G, et al. Science, 2012 Jun 15. PMID 22555433, Free PMC Article
    5. Arabidopsis AtMORC4 and AtMORC7 Form Nuclear Bodies and Repress a Large Number of Protein-Coding Genes. Harris CJ, et al. PLoS Genet, 2016 May. PMID 27171361, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.
      Title: The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.
    2. We demonstrate that the SWI/SNF chromatin-remodeling complex components SWI3B, SWI3C, and SWI3D interact with MORC6 as well as with SUVH9 and then mediate transcriptional silencing. These results suggest that the RdDM components are involved not only in DNA methylation but also in MORC6-mediated heterochromatin condensation.
      Title: Two Components of the RNA-Directed DNA Methylation Pathway Associate with MORC6 and Silence Loci Targeted by MORC6 in Arabidopsis.
    3. synergistic transcriptional regulation in the mom1/atmorc6 double mutant, indicating that these epigenetic regulators act mainly in different silencing pathways, both independently of DNA methylation
      Title: Transcriptional gene silencing by Arabidopsis microrchidia homologues involves the formation of heteromers.
    4. MORC6 influences RNA-directed DNA methylation and that it is not acting downstream of DNA methylation. [MORC6]
      Title: The stochastic silencing phenotype of Arabidopsis morc6 mutants reveals a role in efficient RNA-directed DNA methylation.
    5. Mutations in AtMORC1 and AtMORC6 cause derepression of DNA-methylated genes and transposable elements but no losses of DNA or histone methylation; AtMORC1 and AtMORC6 are members of the conserved Microrchidia (MORC) ATPase family, which are predicted to catalyze alterations in chromosome superstructure. [MORC6]
      Title: MORC family ATPases required for heterochromatin condensation and gene silencing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_101768.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within gene silencing by siRNA-directed DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gene silencing by siRNA-directed DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of defense response to oomycetes IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of gene silencing by regulatory ncRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast envelope HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein
    NP_173344.2
    • Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein; FUNCTIONS IN: ATP binding; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase-like, ATP-binding domain (InterPro:IPR003594); BEST Arabidopsis thaliana protein match is: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein (TAIR:AT4G36280.1); Has 533 Blast hits to 518 proteins in 94 species: Archae - 0; Bacteria - 53; Metazoa - 227; Fungi - 0; Plants - 195; Viruses - 0; Other Eukaryotes - 58 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6594883..6601355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101768.4 → NP_173344.2  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173344.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56Y74, Q9LMB8
      UniProtKB/TrEMBL
      A0A178WHF3, A0A5S9V4G1, A0A654EB60
      Conserved Domains (2) summary
      cd16931
      Location:118 → 239
      HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
      pfam17942
      Location:353 → 491
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q56Y74.1

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