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    HSFA3 heat shock transcription factor A3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831749, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HSFA3
    Official Full Name
    heat shock transcription factor A3
    Primary source
    TAIR:AT5G03720
    Locus tag
    AT5G03720
    See related
    Araport:AT5G03720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA HEAT SHOCK TRANSCRIPTION FACTOR A3; AT-HSFA3; F17C15.140; F17C15_140; heat shock transcription factor A3
    Summary
    Member of Heat Stress Transcription Factor (Hsf) family. Expression is regulated by DREB2A and in turn HSFA3 regulates the expression of hsps Hsp18.1-CI and Hsp26.5-MII35S. Involved in establishing thermotolerence.
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    Genomic context

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    See HSFA3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (971142..974326, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene replication factor C large subunit Neighboring gene Protein kinase superfamily protein Neighboring gene histone deacetylase 2C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis. Friedrich T, et al. Nat Commun, 2021 Jun 8. PMID 34103516, Free PMC Article
    2. Arabidopsis DREB2C functions as a transcriptional activator of HsfA3 during the heat stress response. Chen H, et al. Biochem Biophys Res Commun, 2010 Oct 15. PMID 20849812
    3. Functional analysis of an Arabidopsis heat-shock transcription factor HsfA3 in the transcriptional cascade downstream of the DREB2A stress-regulatory system. Yoshida T, et al. Biochem Biophys Res Commun, 2008 Apr 11. PMID 18261981
    4. A cascade of transcription factor DREB2A and heat stress transcription factor HsfA3 regulates the heat stress response of Arabidopsis. Schramm F, et al. Plant J, 2008 Jan. PMID 17999647
    5. Overexpression of Heat Shock Factor Gene HsfA3 Increases Galactinol Levels and Oxidative Stress Tolerance in Arabidopsis. Song C, et al. Mol Cells, 2016 Jun 30. PMID 27109422, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis.
      Title: Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis.
    2. Findings provide evidence that GolS1 and GolS2 are directly regulated by HsfA3 and that GolS enzymes play an important role in improving oxidative stress tolerance by increasing galactinol biosynthesis in Arabidopsis.
      Title: Overexpression of Heat Shock Factor Gene HsfA3 Increases Galactinol Levels and Oxidative Stress Tolerance in Arabidopsis.
    3. these results indicate that DREB2C and HsfA3 are key players in regulating the heat tolerance of Arabidopsis.
      Title: Arabidopsis DREB2C functions as a transcriptional activator of HsfA3 during the heat stress response.
    4. These results indicate that HsfA3 regulates expression of many heat-inducible genes in the transcriptional cascade downstream of the DREB2A stress-regulatory system and functions in acquisition of thermotolerance under the control of the DREB2A cascade.
      Title: Functional analysis of an Arabidopsis heat-shock transcription factor HsfA3 in the transcriptional cascade downstream of the DREB2A stress-regulatory system.
    5. Altogether these data demonstrate that HsfA3 is transcriptionally controlled by DREB2A and important for the establishment of thermotolerance.
      Title: A cascade of transcription factor DREB2A and heat stress transcription factor HsfA3 regulates the heat stress response of Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001342728.1
    NM_120453.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heat shock transcription factor A3
    NP_001318473.1
    • heat shock transcription factor A3 (HSFA3); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to heat, regulation of transcription, DNA-dependent, response to chitin; LOCATED IN: nucleus; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Heat shock factor (HSF)-type, DNA-binding (InterPro:IPR000232); BEST Arabidopsis thaliana protein match is: heat shock transcription factor A1D (TAIR:AT1G32330.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      971142..974326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001342728.1 → NP_001318473.1  heat shock transcription factor A3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GYY1, Q9LZR6
      UniProtKB/TrEMBL
      A0A178UHR4, A0A5S9Y1E4, A0A654FY53
      Conserved Domains (1) summary
      smart00415
      Location:52 → 145
      HSF; heat shock factor

    2. NM_120453.4 → NP_195992.2  heat shock transcription factor A3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195992.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GYY1, Q9LZR6
      UniProtKB/TrEMBL
      A0A178UHR4, A0A5S9Y1E4, A0A654FY53
      Conserved Domains (1) summary
      smart00415
      Location:52 → 145
      HSF; heat shock factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GYY1.2

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