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    GalAK galacturonic acid kinase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820239, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GalAK
    Official Full Name
    galacturonic acid kinase
    Primary source
    TAIR:AT3G10700
    Locus tag
    AT3G10700
    See related
    Araport:AT3G10700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    galacturonic acid kinase
    Summary
    Encodes a GHMP kinase family protein that acts as a galacturonic acid-1-phosphate kinase that catalyzes the production of galacturonic acid-1-phosphate. This is a precursor of the important cell wall building block UDP-galacturonic acid. Based on gene trap line GT8007, the gene appears to be expressed in a petal and stamen-specific manner, between flower stages 8 to 11, however, later RT-qPCR analysis demonstrates that the transcript is present throughout the plant in all tissues tested.
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    Genomic context

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    See GalAK in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (3346509..3351170, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene DNA GYRASE A Neighboring gene root hair specific 12 Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of galacturonic acid-1-phosphate kinase, a new member of the GHMP kinase superfamily in plants, and comparison with galactose-1-phosphate kinase. Yang T, et al. J Biol Chem, 2009 Aug 7. PMID 19509290, Free PMC Article
    2. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_001337890.1
    NM_001337891.1
    NM_111906.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables galactokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galacturonokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-galacturonate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within carbohydrate phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    galacturonic acid kinase
    NP_187681.2
    • galacturonic acid kinase (GalAK); FUNCTIONS IN: ATP binding, galactokinase activity, galacturonokinase activity; INVOLVED IN: carbohydrate phosphorylation, D-galacturonate metabolic process; LOCATED IN: cytoplasm; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Galactokinase (InterPro:IPR000705), Mevalonate/galactokinase (InterPro:IPR006206), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), GHMP kinase (InterPro:IPR006204), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721), GHMP kinase, C-terminal (InterPro:IPR013750); Has 3493 Blast hits to 3446 proteins in 1360 species: Archae - 42; Bacteria - 2414; Metazoa - 241; Fungi - 181; Plants - 121; Viruses - 0; Other Eukaryotes - 494 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3346509..3351170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111906.4 → NP_187681.2  galacturonic acid kinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187681.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VYG2, Q9CAF7, Q9SG76
      UniProtKB/TrEMBL
      A0A178V5L4, A0A5S9XB58
      Conserved Domains (1) summary
      PLN02865
      Location:1 → 423
      PLN02865; galactokinase

    2. NM_001337890.1 → NP_001326375.1  galacturonic acid kinase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LP31

    3. NM_001337891.1 → NP_001326376.1  galacturonic acid kinase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LP32, A0A5S9XB58
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VYG2.1

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