MCM8 minichromosome maintenance 8 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: MCM8
Official Full Name: minichromosome maintenance 8
Primary source: TAIR:AT3G09660
Locus tag: AT3G09660
See related: Araport:AT3G09660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtMCM8; minichromosome maintenance 8
Summary: Encodes a minichromosome maintenance protein that is involved with RAD51 in a backup pathway that repairs meiotic double strand breaks without giving meiotic crossovers when the major pathway, which relies on DMC1, fails.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

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NM_001337836.1

NM_001337837.1

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair via homologous recombination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within female meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

NP_001319512.1

minichromosome maintenance 8 (MCM8); FUNCTIONS IN: nucleoside-triphosphatase activity, DNA-dependent ATPase activity, DNA binding, nucleotide binding, ATP binding; INVOLVED IN: DNA-dependent DNA replication initiation, DNA replication; LOCATED IN: cellular_component unknown; EXPRESSED IN: shoot apex, embryo, flower, seed; EXPRESSED DURING: F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), ATPase, AAA+ type, core (InterPro:IPR003593), DNA-dependent ATPase MCM (InterPro:IPR001208); BEST Arabidopsis thaliana protein match is: Minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT2G16440.1); Has 4027 Blast hits to 3851 proteins in 539 species: Archae - 371; Bacteria - 134; Metazoa - 1249; Fungi - 930; Plants - 423; Viruses - 3; Other Eukaryotes - 917 (source: NCBI BLink).

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