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    Disease resistance protein (TIR-NBS class) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819576, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Disease resistance protein (TIR-NBS class)
    Primary source
    TAIR:AT3G04210
    Locus tag
    AT3G04210
    See related
    Araport:AT3G04210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T6K12.17; T6K12_17
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (1105650..1108252, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RmlC-like cupins superfamily protein Neighboring gene RmlC-like cupins superfamily protein Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene ncRNA Neighboring gene Ribosomal protein S5 domain 2-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The TIR-NBS protein TN13 associates with the CC-NBS-LRR resistance protein RPS5 and contributes to RPS5-triggered immunity in Arabidopsis. Cai H, et al. Plant J, 2021 Aug. PMID 33982335
    2. The truncated NLR protein TIR-NBS13 is a MOS6/IMPORTIN-α3 interaction partner required for plant immunity. Roth C, et al. Plant J, 2017 Dec. PMID 28901644
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The TIR-NBS protein TN13 associates with the CC-NBS-LRR resistance protein RPS5 and contributes to RPS5-triggered immunity in Arabidopsis.
      Title: The TIR-NBS protein TN13 associates with the CC-NBS-LRR resistance protein RPS5 and contributes to RPS5-triggered immunity in Arabidopsis.
    2. Study uncovered the truncated NLR protein TN13 as a component of plant innate immunity that selectively binds to MOS6/IMPORTIN-alpha3 in planta. [TIR-NBS13]
      Title: The truncated NLR protein TIR-NBS13 is a MOS6/IMPORTIN-α3 interaction partner required for plant immunity.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001337506.1
    NM_111292.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    colocalizes_with endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Disease resistance protein (TIR-NBS class)
    NP_001319465.1
    • Disease resistance protein (TIR-NBS class); FUNCTIONS IN: transmembrane receptor activity, ATP binding; INVOLVED IN: signal transduction, apoptosis, defense response, innate immune response; LOCATED IN: intrinsic to membrane, endomembrane system; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT5G38340.1); Has 7287 Blast hits to 7131 proteins in 234 species: Archae - 2; Bacteria - 61; Metazoa - 8; Fungi - 0; Plants - 7211; Viruses - 0; Other Eukaryotes - 5 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1105650..1108252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337506.1 → NP_001319465.1  Disease resistance protein (TIR-NBS class) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8H1N6, Q93ZI0
      Conserved Domains (2) summary
      pfam01582
      Location:66 → 231
      TIR; TIR domain
      cl21455
      Location:262 → 412
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_111292.4 → NP_566223.1  Disease resistance protein (TIR-NBS class) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566223.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8H1N6, Q93ZI0
      Conserved Domains (2) summary
      pfam01582
      Location:66 → 231
      TIR; TIR domain
      cl21455
      Location:262 → 412
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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