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    REP Rab escort protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819832, updated on 18-Sep-2024

    Summary

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    Official Symbol
    REP
    Official Full Name
    Rab escort protein
    Primary source
    TAIR:AT3G06540
    Locus tag
    AT3G06540
    See related
    Araport:AT3G06540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AthREP; F5E6.13; F5E6_13; Rab escort protein
    Summary
    Encodes a cytoplasmic Rab escort protein that preferentially binds the GDP-bound form of Rab and stimulates geranylgeranylation of various Rab GTPases in Arabidopsis extracts in vitro.
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    Genomic context

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    See REP in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (2034913..2037791, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Glycosyl hydrolase superfamily protein Neighboring gene agenet domain-containing protein Neighboring gene ARM repeat superfamily protein Neighboring gene uncharacterized protein Neighboring gene O-acetyltransferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impact of C-terminal truncations in the Arabidopsis Rab escort protein (REP) on REP-Rab interaction and plant fertility. Gutkowska M, et al. Plant J, 2021 Dec. PMID 34592024, Free PMC Article
    2. Cloning and characterization of Rab Escort Protein (REP) from Arabidopsis thaliana. Wojtas M, et al. Cell Biol Int, 2007 Mar. PMID 17140818
    3. A specific feature of the angiosperm Rab escort protein (REP) and evolution of the REP/GDI superfamily. Hála M, et al. J Mol Biol, 2005 May 20. PMID 15854662
    4. Arabidopsis Rab Geranylgeranyltransferases Demonstrate Redundancy and Broad Substrate Specificity in Vitro. Shi W, et al. J Biol Chem, 2016 Jan 15. PMID 26589801, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impact of C-terminal truncations in the Arabidopsis Rab escort protein (REP) on REP-Rab interaction and plant fertility.
      Title: Impact of C-terminal truncations in the Arabidopsis Rab escort protein (REP) on REP-Rab interaction and plant fertility.
    2. Data suggest that the Rab geranylgeranyltransferase heterodimer RGTA1/RGTB1 catalyzes prenylation of C-terminal cysteine residues in Rab GTPases in the presence of Rab escort protein (REP).
      Title: Arabidopsis Rab Geranylgeranyltransferases Demonstrate Redundancy and Broad Substrate Specificity in Vitro.
    3. We report the cloning and characterization of REP gene of Arabidopsis thaliana. Highest expression of REP mRNA was detected in leaves and flowers in contrast to stems and roots.
      Title: Cloning and characterization of Rab Escort Protein (REP) from Arabidopsis thaliana.
    4. The Rab escort protein gene from Arbisopsis thaliana was cloned and characterized.[AtREP]
      Title: A specific feature of the angiosperm Rab escort protein (REP) and evolution of the REP/GDI superfamily.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111530.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rab geranylgeranyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein geranylgeranylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Rab-protein geranylgeranyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Rab escort protein
    NP_187306.2
    • Rab escort protein (REP); FUNCTIONS IN: RAB GDP-dissociation inhibitor activity; INVOLVED IN: intracellular protein transport, regulation of GTPase activity, protein transport; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Rab GTPase activator (InterPro:IPR002005), Rab protein geranylgeranyltransferase component A, eukaryota (InterPro:IPR016664), Yeast Mrs6p protein (InterPro:IPR000632), GDP dissociation inhibitor (InterPro:IPR018203); BEST Arabidopsis thaliana protein match is: guanosine nucleotide diphosphate dissociation inhibitor 1 (TAIR:AT2G44100.1); Has 1226 Blast hits to 1117 proteins in 247 species: Archae - 0; Bacteria - 2; Metazoa - 578; Fungi - 292; Plants - 178; Viruses - 0; Other Eukaryotes - 176 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2034913..2037791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111530.4 → NP_187306.2  Rab escort protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187306.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LLD4, Q8LPP8, Q9C8Z5
      UniProtKB/TrEMBL
      A0A5S9X9P6
      Conserved Domains (1) summary
      cl21454
      Location:9 → 449
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LLD4.2

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