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    WAG2 Protein kinase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820658, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WAG2
    Official Full Name
    Protein kinase superfamily protein
    Primary source
    TAIR:AT3G14370
    Locus tag
    AT3G14370
    See related
    Araport:AT3G14370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Summary
    The WAG2 and its homolog, WAG1 each encodes protein-serine/threonine kinase that are nearly 70% identical to PsPK3 protein. All three together with CsPK3 belong to PsPK3-type kinases. At the N-terminus, all four possess a serine/threonine-rich domain. They are closely related to Arabidopsis kinases PINOID. wag1/wag2 double mutants exhibit a pronounced wavy root phenotype when grown vertically on agar plates (while wild-type plants develop wavy roots only on plates inclined to angles less than 90 degrees), indicating an overlapping role for WAG1 and WAG2 as suppressors of root waving. Simultaneous disruption of PID(AT2G34650) and its 3 closest homologs (PID2/AT2G26700, WAG1/AT1G53700, and WAG2/AT3G14370) abolishes the formation of cotyledons.
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    Genomic context

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    See WAG2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (4797828..4799612, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ROTUNDIFOLIA like 10 Neighboring gene Uncharacterized protein family (UPF0497) Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WAG2 represses apical hook opening downstream from gibberellin and PHYTOCHROME INTERACTING FACTOR 5. Willige BC, et al. Development, 2012 Nov. PMID 22992959
    2. The WAG1 and WAG2 protein kinases negatively regulate root waving in Arabidopsis. Santner AA, et al. Plant J, 2006 Mar. PMID 16460509
    3. PINOID AGC kinases are necessary for phytochrome-mediated enhancement of hypocotyl phototropism in Arabidopsis. Haga K, et al. Plant Physiol, 2014 Nov. PMID 25281709, Free PMC Article
    4. Plasma membrane-bound AGC3 kinases phosphorylate PIN auxin carriers at TPRXS(N/S) motifs to direct apical PIN recycling. Dhonukshe P, et al. Development, 2010 Oct. PMID 20823065
    5. NPY genes and AGC kinases define two key steps in auxin-mediated organogenesis in Arabidopsis. Cheng Y, et al. Proc Natl Acad Sci U S A, 2008 Dec 30. PMID 19075219, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WAG2 is necessary for phytochrome-mediated enhancement of hypocotyl phototropism in Arabidopsis.
      Title: PINOID AGC kinases are necessary for phytochrome-mediated enhancement of hypocotyl phototropism in Arabidopsis.
    2. WAG2 is a crucial transcription target during apical hook opening downstream from GA signaling
      Title: WAG2 represses apical hook opening downstream from gibberellin and PHYTOCHROME INTERACTING FACTOR 5.
    3. identified the PID homologs WAG1 and WAG2 as new PIN polarity regulators.
      Title: Plasma membrane-bound AGC3 kinases phosphorylate PIN auxin carriers at TPRXS(N/S) motifs to direct apical PIN recycling.
    4. wag1 and wag2 are protein kinases that negatively regulate root waving in Arabidopsis. [wag2]
      Title: The WAG1 and WAG2 protein kinases negatively regulate root waving in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_112295.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cotyledon development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT involved_in gravitropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase superfamily protein
    NP_188054.1
    • WAG2; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: WAG 1 (TAIR:AT1G53700.1); Has 104032 Blast hits to 102948 proteins in 2832 species: Archae - 68; Bacteria - 12398; Metazoa - 38403; Fungi - 11620; Plants - 23519; Viruses - 432; Other Eukaryotes - 17592 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4797828..4799612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112295.4 → NP_188054.1  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188054.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LUL2
      UniProtKB/TrEMBL
      A0A178VAK4, A0A5S9XC35
      Conserved Domains (1) summary
      cd05574
      Location:86 → 420
      STKc_phototropin_like; Catalytic domain of Phototropin-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LUL2.1

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